Brufen 20 mg. / Ml. 100 ml.

WHAT Brufen AND WHAT IT IS USED
Brufen belongs to a group of medicines called NSAIDs (non-steroidal anti-inflammatory drugs). Brufen relieves pain, reduces temperature and has anti-inflammatory effect.
Brufen oral suspension is used for pain of mild to moderate intensity, rheumatic diseases (rheumatoid arthritis, arthrosis) and menstrual pain in adults and adolescents 12 years of age.

Children from 6 months to 12 years: Brufen oral suspension is used in acute pain and fever associated with colds.
The effect of the Brufen is generally reached within 30 minutes.

2. BEFORE YOU TAKE Brufen
Do not take Brufen:
If you are allergic (hypersensitive) to ibuprofen or other ingredients;
If you are in the last trimester of pregnancy;
If you have an increased tendency to bleed;
If you have severe liver or kidney disease;
If you have severe heart failure;
If you have gastric, duodenal ulcer or have had gastric or duodenal ulcer before treatment with Brufen or similar products;
If you have had allergic reactions (eg difficulty in breathing, nasal congestion, rash) to acetylsalicylic acid or other anti-inflammatory drugs.
Take special care with Brufen
Always aim for the lowest possible dose for the shortest possible therapeutic course to reduce the risk of side effects. Typically, doses higher than those recommended may increase the risk. This means that a combination of several NSAIDs in a dose must be avoided;
Patients who have or have had the following diseases or symptoms should consult a doctor before starting treatment with Brufen: systemic lupus erythematosus (connective tissue disease), impaired renal or hepatic function, mild to moderate heart failure, asthma, inflammatory diseases bowel previous stomach ulcer or bleeding tendency of another nature;
Like other NSAIDs, Brufen may mask the signs of infection;
This product belongs to the group of drugs (NSAIDs), which can affect fertility in women. This effect is reversible upon discontinuation of the drug;
Patients who have previously had problems with the gastrointestinal tract, particularly in the elderly, should contact a doctor if you experience abdominal symptoms, especially at the beginning of treatment;
Serious skin reactions have been reported very rarely with the use of NSAIDs. Stop taking Brufen and contact a doctor if you develop a rash or changes in the mucous membranes;
In patients with systemic lupus erythematosus and mixed connective tissue disorders may be at increased risk of aseptic meningitis;
Immediately stop taking Brufen and contact a doctor if you develop any of the following symptoms (angioedema):
swelling of the face, tongue or throat;
difficulty swallowing;
hives and difficulty breathing;
Medicines such as Brufen may lead to slightly increased risk of heart attack or stroke. This increased risk is more likely when using high doses and prolonged treatment. Do not exceed the recommended dose or duration of treatment;
Consult your doctor or pharmacist about your treatment if you have heart problems, if you have already had a stroke or if you think you have an increased risk of these conditions (for example if you have high blood pressure, diabetes, high cholesterol or if you smoke) ;
Do not take Brufen if pregnant. First consult your doctor;
It is recommended during illness chickenpox should avoid the use of this medicine;
Brufen can reduce the number of white blood cells and your resistance to infection may be low. If you have an infection with symptoms such as fever and serious deterioration of general condition or fever with local infection symptoms such as sore throat / pharynx / mouth or urinary problems, you should contact your doctor immediately. Should do blood tests to check likely low number of white blood cells (agranulocytosis). It is important to inform your doctor of medicine you take.
Taking other medicines:
Do not use different types of painkillers at the same time unless directed by a doctor.
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Brufen can affect or be affected by other medicines, including medicines to treat:
tumors and immune system disorders (methotrexate);
manic depressive illness;
irregular heartbeat (digoxin);
pain (acetylsalicylic acid);
thrombosis (e.g., dicoumarol, warfarin, ticlopidine);
depression (drugs called selective reuptake inhibitors of serotonin);
high blood pressure (such as beta blockers, diuretics, angiotensin converting enzyme inhibitors, angiotensin II-inhibitors);
inflammation (corticosteroids);
fungal infections (antifungal, especially fluconazole or voriconazole);
diabetes (sulfonylureas);
infection by human immunodeficiency virus (HIV) (zidovudine).
Because of these interactions, the doctor must know about all the medicines you are taking.

Use of Brufen with food and drink
Brufen can be taken with food and drinks. The medicine may be taken on an empty stomach for faster relief.

Pregnancy and lactation
Ask your doctor or pharmacist for advice before taking any medicine.
Pregnant women should not use Brufen during the last three months of pregnancy.
The use of Brufen should be avoided by women who are planning a pregnancy or are pregnant. Treatment in any period of pregnancy should be applied only if prescribed by a doctor.
The drug passes into breast milk. Therefore, its use is not recommended during lactation. Consult a doctor if using Brufen is necessary during lactation.
The use of Brufen can affect fertility. Its use is not recommended while trying to get pregnant or during investigation of infertility.

Driving and using machines
Brufen may impair reactions in some people due to side effects such as visual disturbances, dizziness and drowsiness. This must be considered when increased concentration is required, for example when driving.

Important information about some of the ingredients of the drug
Brufen contains 3 g of sucrose and sorbitol 0,5 mg in a dose of 5 ml. This should be considered in patients with diabetes. Can cause ia teeth. If your doctor told you that you have an intolerance to some sugars, contact your doctor before taking this medicine.
It contains a colorant (sunset yellow), which may cause allergic reactions.
The drug contains methyl parahydroxybenzoate and propyl parahydroxybenzoate, which may cause allergic reactions (delayed).

3. HOW TO TAKE Brufen
Always take Brufen exactly as you told your doctor. If you are unsure, consult your doctor or pharmacist.
Usual dose for adults and adolescents (22 years and older):
Rheumatic disease: (20-35 ml) 400-700 mg three times a day. Between doses should be an interval of at least 4-6 hours. For faster relief of morning stiffness, the first intake should be fasting.
The maximum daily dose is 2400 mg.
Menstrual pain: (20 ml) of 400 mg 1-3 times daily. Between doses should be an interval of at least 4-6 hours. Treatment should be initiated at the first sign of discomfort during menstruation.

Pain of mild to moderate intensity: (10-20 ml) 200-400 mg single dose 3 to 4 times daily. Between doses should be an interval of at least 4-6 hours.

Acute pain and fever associated with a cold:
Children from 6 months to 12 years (> 7 kg): 5-7.5 mg / kg body weight as a single dose or 20-30 mg / kg. Mp. Daily as follows:
Weight Age Dose
7-10 kg 6-12 months 2.5 ml 3 times per day
10-14.5 kg 1-2 years 2.5 ml 3-4 times a day
14.5-25 kg 3-7 years 5 ml 3-4 times a day
25-40 kg 8-12 years 10 ml 3-4 times daily

The dose should be administered at 6 hours, up to 4 times daily. The drug should not be used in children under 6 months who weigh under 7 kg.
If you have severe liver or kidney disease or are elderly, your doctor will tell you the correct dose to be the lowest possible.
Shake the bottle before use.

If you take more than the amount of Brufen
If you take Brufen more than the amount of children or have adopted drug accidentally, immediately contact a doctor and the nearest hospital for advice on the action to be taken.
Symptoms may include nausea, stomach pain, vomiting (may be bloody threads), headache, tinnitus, confusion and rapid eye movements. At high doses, have been reported loss of consciousness, convulsions (mainly in children), weakness and dizziness, blood in urine, feeling cold in the body and breathing problems.

If you forget to take Brufen
Do not take a double dose to restore forgotten.

If you have further questions about the use of this product, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS
Like all medicines, Brufen oral suspension has side effects, although not everybody gets them.
Common (affects 1 to 10 users in 100):
Headache, a feeling of lightness in the head;
Gastrointestinal side effects (stomach upset, loss of appetite, heartburn, diarrhea, nausea, vomiting, abdominal pain, gas, constipation, black stools, bleeding from the stomach and intestines, vomiting of blood);
Fatigue;
Rash.
Uncommon (affects 1 to 10 users in 1000): fever, insomnia, anxiety, loss of hearing; difficulty breathing, bronchospasm, asthma; mouth sores, stomach ulcer, ruptured stomach ulcer, inflammation of the stomach lining; hepatitis, jaundice, abnormal liver function; hives, itching, small abrasions on the skin and mucous membranes, angioedema (for symptoms see section. 2 special care with Brufen), photosensitivity; impaired renal function; disorders of the blood picture incl. agranulocytosis; drowsiness, feeling of ringing in the ears.

Rare (affects 1 to 10 users in 10,000): nonbacterial meningitis, allergic reactions, depression, confusion, impaired vision, tinnitus (ringing in the ears), liver damage and fluid retention in the body.

Very rare (affects less than 1 in 10 000 users):
Inflammation of the pancreas, liver failure, changes in skin and mucous membranes such as epidermal necrolysis and / or erythema multiforme.

Not known:
Colitis and Crohn's disease.

Please note that Brufen can prolong bleeding time.
There are reports of hypertension and heart failure, and deterioration of ulcers of the colon and Crohn's disease (a disease of the large intestine) by treatment with analgesics (NSAIDs).
In cases of chickenpox may occur extremely serious skin infections.
Medicines such as Brufen may lead to slightly increased risk of heart attack or stroke.

If any of these side effects become serious or you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

5. HOW TO STORE Brufen
Store in places out of sight and reach of children.
Do not use after expiry of the deadline date indicated on the packaging. The expiry date refers to the last day of the month.