DURACEF suspension. 250 mg. / 5 ml. 60 ml.

WHAT DURACEF AND WHAT IT IS USED
DURACEF 250 mg / 5 ml powder for oral suspension contains a drug 250 mg as cefadroxil cefadroxil monohydrate in 5 ml of reconstituted solution.
DURACEF (cefadroxil) is a semisynthetic cephalosporin antibiotic for oral administration.
DURACEF be used to treat these infections, caused by susceptible microorganisms of cefadroxil:
urinary tract infections;
infections of skin and soft tissues;
respiratory tract infections (pharyngitis and tonsillitis).

2. BEFORE YOU TAKE DURACEF
Do not take DURACEF
if you are allergic (hypersensitive) to cefadroxil monohydrate or any other ingredients of Duratsef;
if you are allergic (hypersensitive) to the cephalosporin group of antibiotics.
Take special care with DURACEF
if you are allergic to penicillin. Cephalosporin antibiotics should be used with caution in patients allergic to penicillin. There are cases of patients with an allergic reaction to the two types of antibiotics (including fatal anaphylaxis after parenteral use);
if after taking Duratsef appear diarrhea. There have been reports of pseudomembranous colitis (severe inflammation of the bowel) for use of cephalosporins (and other broad spectrum antibiotics), so it is important to bear in mind the diagnosis of patients in whom appears diarrhea associated with antibiotic use;
if you have impaired kidney function.DURACEF (cefadroxil) should be used with caution in patients with impaired renal function;
if you have gastrointestinal disorders. DURACEF should be prescribed with caution in patients with gastrointestinal disease, particularly colitis.
Taking other medicines
No studies on interactions with other medicines.
During therapy with cephalosporin antibiotics can occur a false positive direct test Coombs (a type of blood test). May receive false positive results in the determination of glucose in urine.

Tell your doctor if you take:
other antibiotics (aminoglycosides, polymyxin B, vancomycin, colistin);
medicines for drainage (diuretics);
probenecid (a medicine for gout);
drugs to prevent blood clotting (warfarin, aspirin);
birth control pills.
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Taking DURACEF with food and drink
DURACEF is acid resistant and can be taken with or without food.
Adoption at mealtimes can be useful because it reduces the possible complaints from the gastrointestinal tract, sometimes associated with treatment with cephalosporins.

Pregnancy and lactation
This product can be used during pregnancy only if clearly expressed need.
DURACEF is distributed into breast milk, therefore be used with caution in nursing mothers.
Ask your doctor or pharmacist before taking any medicine.

Driving and using machines
No studies on the effects on ability to drive and use machines.

Important information about some of the ingredients of DURACEF
DURACEF oral suspension contains sucrose. If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this product.

3. HOW TO TAKE DURACEF
Always take Duratsef just as you have been told by your doctor. If you're not sure, ask your doctor or pharmacist.

Method of preparation:
Shake or shake the bottle well to not adhere to the walls of the powder content, add the required amount of water (see below) into two portions. Take the bottle and shake well after each addition. When solutions as indicated, 5 ml of the resulting suspension contained 250 mg as cefadroxil monohydrate, depending on the concentration.
Total volume of the bottle of water for solution
60 ml 40 ml
The usual dose is:
Adults and children weighing over 40 kg:
Urinary tract infections
The typical dose in uncomplicated infections of the lower urinary tract (eg. Cystitis) is 1 to 2 g per day in a single dose or divided into 2 doses.
In all other urinary tract infections the dose is usually 2 g, divided into 2 doses.

Skin infections
Typically, dosages in skin infections in 1 g once a day or divided into 2 doses.

Pharyngitis and tonsillitis (throat infections) caused by beta-hemolytic group A streptococci
For the treatment of beta-hemolytic streptococcus group A with tonsillitis and pharyngitis recommended 1 g once daily or divided into two doses.

Children weighing less than 40 kg:
The recommended daily dose for children is 25-50 mg / kg / day - twice a day every 12 hours.
Duratsef powder for oral suspension (dose for 12 hours)
Body weight of the child
250 mg / 5 ml (50 mg / ml)
5 -
10 2.5 to 5 ml
15 3,75 - 7,5 ml
20 5-10 ml
25 6,25 - 12,5 ml
In the treatment of beta-hemolytic streptococcal infection therapeutic dose of Duratsef should be administered at least 10 days. For the treatment of beta-hemolytic streptococcal pharyngitis or tonsillitis in adults and children Duratsef (cefadroxil) may be administered once or twice daily.

Renal impairment:
In patients with renal impairment, the dosage of cefadroxil should be adjusted depending on the values of clearance to prevent accumulation of the drug.

If you take more dose DURACEF
If you take more dose DURACEF consult a doctor or go to the nearest emergency department.
Administering an amount below 250 mg / kg DURACEF or another cephalosporin is not associated with toxicity and does not require special treatment. Upon acceptance of quantities above 250 mg / kg (5 to 10 times the recommended dose) have been reported some cases of gastrointestinal disorders and rash.

If you forget to take DURACEF
If you miss a dose, take it as soon as you remember. If it is time for your next dose, take it as usual and continue to take Duratsef according to the prescribed schedule. Do not take a double dose to make up the missed dose.

If you stop taking DURACEF
Do not stop taking DURACEF, even if you feel better. Finish the course of treatment as prescribed by the doctor. Premature discontinuation of treatment may cause resumption of infection.

4. POSSIBLE SIDE EFFECTS
Like all medicines, DURACEF can cause side effects, although not everybody gets them.
Gastrointestinal disorders - can be symptoms of pseudomembranous colitis during treatment with antibiotics. Common side effects are nausea, vomiting and indigestion. Adoption during meals reduces nausea, without interfering with the absorption. Sometimes it appears and diarrhea.

Hypersensitivity - allergies were observed in the form of itching, rash, urticaria and angioedema (swelling of the face, eyelids, tongue, throat). Rarely reported erythema multiforme syndrome, Stevens-Johnson (severe skin reactions with blistering), serum sickness, and anaphylaxis. These reactions usually resolve with discontinuation.

Other side effects: genital itching, genital candidiasis (fungal infection of the genitals), vaginitis (inflammation of the vagina), moderate neutropenia (low white blood cell) and a slight increase in serum transaminases (liver function tests). As with other antibiotics in this class are rarely reported agranulocytosis (disappearance of certain types of blood cells), thrombocytopenia (low platelets) and arthralgia (joint pain).

If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.

5. HOW TO STORE DURACEF
Store below 30 ° C in a dry place.
Keep out of reach of children.
Do not use DURACEF after the expiry date stated on the carton. The expiry date refers to the last day of that month.
After reconstitution, as indicated (see section 3. HOW TO TAKE DURATSEF, Preparation) Duratsef reconstituted powder for oral suspension is stable for seven days at room temperature (Keep in a cool, dry place) or 14 days if stored in a refrigerator. Shake well before use. Keep the bottle tightly closed. Any unused portion be discarded after 7 days storage at room temperature or after 14 days storage in a refrigerator.

6. ADDITIONAL INFORMATION
What DURACEF
The active substance is cefadroxil monohydrate.
Other ingredients are: sodium benzoate, xanthan gum, polysorbate 40, sucrose, titanium dioxide, artificial raspberry flavors, lemon, strawberry flavor Permaseal.

DURACEF looks like and contents of the pack
DURACEF powder for oral suspension is available for oral administration in a concentration of 250 mg / 5 ml in HDPE bottles with polyethylene caps containing 60 ml.