FLEXISTAD. 600 mg. 20 tablets

1 tablet contains : active substance : Ibuprofen 600 mg
Excipients: magnesium stearate , corn starch , iatriy - carboxymethyl cellulose , hydroxypropyl methyl cellulose , macrogol 400 , macrogol 6000 (Magnesium stearate, maize strach, carboxymethylcellulose sodium, hydroxypropil methyl cellulose, macrogol 400 , macrogol 6000 )
 
Performance and size of the package:
Original pack of 20 tablets
 
Original package with 50 tablets
Original package with 100 tablets
Anti-inflammatory and analgesic drug ( NSAID / analgesic drug)
 

 
 
indications:
Symptomatic treatment of pain and inflammation in :
D acute arthritis / including gout attacks /
□ chronic arthritis , especially rheumatoid arthritis / chronic polyarthritis /
□ ankylosing spondylitis (Bechterew's disease ) and other inflammatory -rheumatic disorders of the spine
□ irritative conditions in degenerative joint and spine diseases and / osteo and spondylarthrosis /
□ inflammatory rheumatic diseases of soft tissues /
□ painful swelling and inflammation after trauma and injuries
 
 
Contraindications :
When you must not take Fleksistad 600 ?
 
Flexistad 600 shall not apply to:
 
□ with known hypersensitivity to the active substance Ibuprofen or any of the excipients
□ in unexplained disturbances haematopoietic ( blood formation )
□ in patients with gastrointestinal ulcers
□ in patients with gastrointestinal diseases, cerebrovascular ( Brain sydovi ) or other active hemorrhage ( bleeding )
D severe heart failure
□ in the last trimester of pregnancy
□ with her children adolescents under 15 years
 
 
When you can take Flexistad 600 only after consultation with your doctor ?
Flexistad 600 must be used with caution and special caution in the below listed conditions. Discuss with your doctor if any of these conditions have occurred earlier in you.
You must apply Fleksistad 600 with particular caution (using a longer interval between doses or reduced doses ) and medical control under the following conditions :
□ congenital abnormalities in blood formation (acute intermittent porphyria )
D some autoimmune disorders ( systemic lupus erythematosus and mixed form of collagen )
□ gastrointestinal diseases or suspected gastrointestinal ulceration or chronic inflammation of the bowel ( ulcerative colitis, Crohn's disease pa )
□ hypertension and / or heart failure,
□ existing renal insufficiency
□ severe impairment of liver function
□ soon after major surgery
 
 
 What should I observe lo ka during pregnancy and lactation ?
 
If you become pregnant during prolonged intake of 600 Fleksistad , contact your doctor. Use Fleksistad 600 in the first two quarters of pregnancy only after consulting your doctor.
Fleksistad 600 should not be used in the last trimester of pregnancy because of the risk of complications for mother and child during childbirth .
 
 
What should be kept in mind while nursing a child?
Small amounts of the active ingredient Ibuprofen and its metabolites are excreted in breast milk. Since at present there are no known negative consequences for infants for short-term drug intake is not necessary interruption of breastfeeding. In the long-term administration , however, and / or high dosage of the product , it is necessary to discontinue breastfeeding .
 
What should be considered in children and people in advanced age?
Children and young people under 15 should not use Fleksistal 600, since the content of the drug is too high for this age group. For this age group suitable for other forms of reduced concentration pa drug veshtestvo.Pri children under 6 years of drug Fleksistad 600 should not apply because, in this age group lacks sufficient clinical experience.
In elderly patients need particularly careful medical supervision.
 
 
Special warnings and precautions:
 
What precautions you should consider ?
Drugs such as Flexistad 600 can be associated with a small increased risk of heart attack ( " myocardial miokardek " ) or stroke. Any risk is more likely with high doses and prolonged treatment. Do not exceed the recommended dose and duration of treatment. If you have problems heart , stroke or think that you might be at risk of these conditions (for example if you have high blood pressure, diabetes or high cholesterol or are a smoker) you should discuss treatment with your doctor or pharmacist.
Patients suffering from startled rhinitis, chronic swelling of the nasal mucosa ( nasal polyps ) , chronic obstructive diseases of the airways (asthma ) , as well as patients with a hypersensitivity to other antirheumatic and analgesic agents from the group of anti-inflammatory agents nesteroidnnte may apply Fleksistad 600 only under certain precautions and direct medical supervision. For those patients who use Fleksistad 600, there is a high risk of getting a hypersensitivity ( allergic) reactions. They can be expressed as asthma attacks (so-called analgesic asthma) , swelling of the skin and mucosa (angioedema) or urticaria.
Particular caution should be exercised in patients who have shown allergic reactions " ( rash and itching) to other substances , as these patients have an increased , risk of developing hypersensitivity reactions using Fleksistad 600 .
Ibuprofen, the active ingredient in . Fleksistad 600, can reduce blood platelet aggregation ( blood clotting) . Patients with coagulation disorders should be carefully monitored.
If you take with Fleksistad 600 and anticoagulants ( drugs that reduce blood clotting) or oral antidiabetic medicines, your doctor should regularly monitor performance , coagulation and blood glucose concentration in order to avoid potential problems.
Co-administration of Fleksistad 600 with lithium products ( medicines used to treat manic disorders ) or some water tablets ( potassium-sparing diuretics ) require controlling the concentration of littiy or potassium in the blood. (see " Drug Interactions " ) .
Prolonged treatment with Fleksistad 600 requires regular monitoring of liver and kidney function , and blood count.
Consult and inform your doctor or dentist if you have taken Fleksistad 600 before surgery or dental surgery .
 
 
What you should consider when driving , operating machinery or work without safe foothold ?
 
Applying Fleksistad 600 in high doses can lead to disturbances in the central nervous system fatigue and dizziness, and thus affect your ability to drive motor vehicles and / or your ability to operate machinery.
As a result, you will not be able to respond to unexpected or sudden incidents quickly enough and carefully. You should not operate a car or other motor vehicle. Should not operate electrical appliances or machines. Should not work without safe foothold . '
 
 
What else should be considered ?
Prolonged administration of high doses of pain killer can cause headaches , which should be treated with increased doses of this lekarstvo.Redovnoto use of painkillers , especially when taken in several analgesic combination can lead to permanent kidney damage with the risk of kidney failure ( renal disease induced by analgesics ) .
Adoption of ibuprofen, as with any drug , depressing prostaglandin synthesis could impede the onset of pregnancy. In case of such problems , or if you become pregnant , contact your doctor.
 
 
Drug interactions ;
For other drugs which are known to interfere with the effect of 600 and how Fleksistad Fleksistad 600 impedes the effect of other drugs ? What should you have in mind when using other drugs at the same time ? Please note that these precautions apply to medicinal products stopped shortly before the start of therapy лекарството.Едновременното adopting Fleksistad 600 with digoxin (a medicine used to strengthen the heart) , phenytoin ( anticonvulsant drug) or lithium products ( drugs for the treatment of manic mental disorders) may lead to increased serum concentrations of the latter drug .
Fleksistad 600 can reduce the effect of diuretics and antihypertensive drugs ( water pills and blood pressure lowering drugs ) .
Fleksistad 600 may reduce the effect of ACE-inhibitors ( drugs for the treatment of heart failure and hypertension ) . Concomitant use of these drugs may increase the risk of renal impairment .
Co-administration of Fleksistad 600 and potassium-sparing water pills ( diuretics ) can lead to hyperkalemia (increased concentration of potassium in the blood). Coadministration of Fleksistad 600 other NSAIDs or glucocorticoids increases the risk of gastrointestinal side effects (see " Undesirable effects") -
Applying Fleksistad 600 within 24 hours before or after administration of methotrexate can lead to an increase in the concentration of methotrexate, and therefore to increase the toxic effects of methotrexate.
Simultaneous use of certain non-steroidal anti-inflammatory drugs increases the risk of kidney damage by cyclosporin ( a drug used to prevent transplant rejection , as well as for the treatment of rheumatic diseases ) . This effect also applies to the combination of cyclosporine with ibuprofen .
Products containing probenecid or sulfinpyrazone (a medicine used for gout ) may delay the broadcast of NSAIDs . This can result in accumulation of the ibuprofen in blood and exacerbation of its side effects .
There are isolated reports of interactions between Fleksistad 600 antikoagulaiti . Coagulation should be monitored when taking both ibuprofen and antikoagulaiti .
Clinical studies have shown interaction between NSAIDs and sulfoiilureyni products (oral antidiabetic agents ) . Although there is no link between ibuprofen and sulfoiilureyni product described that patients receiving both drugs should be monitored glgokozata concentration in the blood to avoid pote1shtialni complications.
 
 
What food and drink you should avoid ?
Turn off the alcohol during treatment with Fleksistad 600 .
 
 
Dosing and administration , duration of therapy
These instructions apply only if your doctor prescribes otherwise for medicine ■ Fleksistad 600 . Please follow the usage instructions for effective and safe treatment Fleksistad 600 .
 
 
How much Fleksistad 600 tablets you need to take and how often should you take medicine?
For the treatment of rheumatic diseases :
Ibuprofen dosed according to age and body teglo.Preporachitelnoto dosage for adults and adolescents over 15 years is between 1200mg and 2400mg Ibuprofen a day. The maximum single dose amounted to 800 mg Ibuprofen.
How and when to apply Fleksistad 600 ?
 
Fleksistad 600 film-coated tablets swallowed whole with sufficient fluid and not on an empty stomach . Recommended Fleksistad 600 tablets be taken during meals .
 
 
How long you can apply Fleksistad 600 ?
In rheumatic diseases treatment Fleksistad 600 may continue for a longer period of time. The duration of treatment will solve the doctor .
 
 
Dosing and administration errors
Take Fleksistad 600 as prescribed by your doctor and / or follow the instruction of this leaflet. If pain relief is inadequate, you should not increase your dose at its discretion and consult your doctor. If you miss a dose, you should not take more than the usual dose the next time .
 
What should you do if you use too much of Fleksistad 600
( intentional or accidental overdose of the product) ?
 
Symptoms of overdose may include disturbances of the central nervous system : headache, dizziness, lightheadedness , loss of consciousness (in children also myoclonic spasms ) and abdominalia (stomach ) pain , nausea and vomiting. Patients may experience gastrointestinal bleeding and interfere with the function of the liver and kidneys. An overdose may lead to a drop in blood pressure , respiratory depression and bluish / reddish discoloration of the skin and mucous membranes ( cyanosis ) .
 
No specific antidote .
If you suspect overdose of Fleksistad 600, immediately consult your physician depending on the degree of intoxication will decide whether to take specific measures.
 
 
Undesirable effects
 
What side effects may occur with the use of Fleksistad 600 and what steps you should take ?
Drugs such Fleksistad 600 may be associated with a slightly increased risk of heart attack ( " MI " ) or insult.Pri the below side effects must be considered that they are predominantly a dose - dependent and dependent on the individual peaktsii patients . particularly increased risk of gastrointestinal bleeding (ulcers, mucosal defects . gastritis ) depends on the dosage and duration of treatment.
Can often meet the following side effects:
□ gastrointestinal complaints such as heartburn , stomach pain , nausea, vomiting , diarrhea, constipation , and slight gastrointestinal bleeding , which may exceptionally lead to anemia .
 
Sometimes it can be observed the following adverse reactions :
□ gastrointestinal ulcer with bleeding and / or perforation in separate sluchaiAko appear severe pain in the upper abdomen or vomiting blood and / or blood / jet-black stools, stop taking Fleksistad 600 and urgently consult a doctor.
□ headache , dizziness , insomnia, agitation, irritability and fatigue.
 
Rare side effects may include:
□ increase fluid retention in the tissues forming the swelling (edema ) , especially in patients with hypertension or renal failure
□ nephrotic syndrome (fluid retention in the body - edema and significant protein excretion in the urine )
□ inflammatory kidney disease (interstitial nephritis) , which may be accompanied by acute renal failure.
Decreased urination , fluid retention in the body ( edema) and malaise can be an expression of renal impairment to renal failure.
If these symptoms occur or worsen , stop taking Fleksistad 600 urgently consult a doctor
□ hypersensitivity by skin rash and skin itching , as well as an asthma attack ( with possible lowering of blood pressure )
□ visual disturbances
In this case, consult a doctor immediately and stop taking Fleksistad 600 .
 
There are isolated reports of :
Q ia esophageal inflammation
□ Development membranopodobni narrowing of the intestine
□ ia severe skin reactions such as skin redness and raiichki with bubbles (erythema multiforme)
□ renal tissue / necrosis of the renal papilla / , especially for long-term treatment
□ increase the concentration of uric acid in the blood
□ liver damage , especially during long-term treatment
□ raising the blood pressure , heart failure
 
If any of these symptoms meet or worsen , stop taking Fleksistad 600 and urgently consult a doctor.
□ disturbances in blood formation / anemia , leukopenia , thrombocytopenia , pancytopenia , agranulocytosis /
First signs and symptoms may include: conditions with fever, sore throat, superficial wounds in the mouth , flu-like symptoms , fatigue , bleeding from the nose and skin. Patients who meet these symptoms , you should immediately stop taking Fleksistad 600 and urgently consult a doctor . Self-medication with analgesics and / or temperature -lowering drugs is contraindicated.
□ common severe hypersensitivity reactions . They may be expressed in : edema ( edema ) of the face, the swelling of the tongue and larynx with laryngeal airway narrowing , palpitations , low blood pressure, to the point of life threatening shock . If any of these effects occur at the first reception pa product needed immediate medical attention.
 
Q tinnitus , decreased hearing ia
□ psychotic reactions , depression
□ hair loss ( alopecia )
□ symptoms of aseptic meningitis (inflammation of the pia mater ) with a stiff neck , headache, nausea , vomiting, elevated temperature conditions or disturbances in consciousness. Are predisposed patients with autoimmune disease (SLE - systemic lupus erythematosus, mixed connective tissue disease ) .