GRANEGIS 2 mg. 5 tablets

WHAT GRANEGIS AND WHAT IT IS USED
Granegis contains a medicine called granisetron. It belongs to a group of medicines called antagonists of 5-HT receptors or antiemetics. This medicine is for adults only.
Granegis be used to prevent or treat nausea and vomiting caused by other treatments, such as chemotherapy or radiotherapy for cancer.

2. BEFORE YOU TAKE GRANEGIS FILM-COATED TABLETS
Do not take tablets Granegis
if you are allergic (hypersensitive) to granisetron or any of the other ingredients of Granegis (listed in item. 6).
If you are not sure, ask your doctor, nurse or pharmacist before taking these tablets.

Take special care with Granegis
Talk to your doctor, nurse or pharmacist before using these tablets, if:
have delayed passage of gut due to blockage of the gastrointestinal tract (gut);
you have heart problems, treated for cancer with a drug which is known to damage your heart or have problems with the content of salts, eg. potassium, sodium or calcium, in your body (electrolyte imbalances);
taking other medicines of the 5-HT3 receptor antagonists. These include dolasetron, ondansetron used as Granegis for the treatment and prevention of nausea and vomiting.
children
Children should not take these tablets.

Taking other medicines
Please tell your doctor, nurse or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription, because Granegis may affect the way some other medicines. Also some other medicines can affect the way these tablets.
In particular, tell your doctor, nurse or pharmacist if you are taking any of the following medications:
medicines used to treat irregular heartbeat, other medicines of the 5-HT3 receptor antagonists, eg. dolasetron or ondansetron (see "Take special care with Granegis" above);
phenobarbital - a medicine used to treat epilepsy;
drug called ketoconazole used in the treatment of fungal infections;
erythromycin antibiotic used to treat bacterial infections.
Pregnancy and lactation
You should not take these tablets if you are pregnant, trying to become pregnant or breast-feeding, unless your doctor tells you.
Ask your doctor, nurse or pharmacist before taking any medicine.

Driving and using machines
Granegis no influence to a minor influence on the ability to drive or operate any tools or machines.

Important information about some of the ingredients of Granegis
This medicine contains lactose (a type of sugar). If your doctor told you that you have an intolerance to some sugars, contact him before taking this medicine.

3. HOW TO TAKE GRANEGIS
Always take Granegis exactly as prescribed by your doctor. If you are not sure, ask your doctor or pharmacist.
The dose of Granegis is different for each patient. It depends on your age, weight, and whether the drug is given to you to prevent or treat nausea and vomiting. The doctor will decide what dose to give you.

Prevention of nausea or vomiting
Granegis first dose will usually be given an hour before radiotherapy or chemotherapy. The dose will be one or two tablets of 1 mg or one 2 mg tablet once a day to one week following radiotherapy or chemotherapy.

Treatment of nausea or vomiting
The dose will usually be one or two 1 mg tablets or one 2 mg tablet once a day, but your doctor may decide to increase the dose to nine tablets of 1 mg per day.

If you take more dose Granegis tablets
If you think you have taken too many tablets, contact your doctor or nurse. Symptoms of overdose include mild headaches. You will be treated depending on your symptoms.

If you forget to take Granegis
If you think that you forget to take your medicine you should contact your doctor or nurse.
Do not take a double dose to make up for a forgotten tablet.

If you stop taking Granegis
Do not stop taking your medicine before the treatment is completed. If you stop taking your medicine, your symptoms may reappear.

If you have any further questions on the use of this product, ask your doctor, nurse or pharmacist.

4. POSSIBLE SIDE EFFECTS
Like all medicines, Granegis can cause side effects, although not everybody gets them. If you notice any of the following symptoms, you should immediately seek medical help:
allergic reactions (anaphylaxis). Symptoms may include swelling of the throat, face, lips and mouth, difficulty breathing or swallowing.
Other side effects, which may be obtained from use of this product are:
Very common: affects more than 1 in 10 users:
headache;
constipation. Your doctor will monitor your condition.
Common: affects 1 to 10 users in 100:
sleep disorders (insomnia);
changes in the function of your liver, visible blood tests;
diarrhea.
Uncommon: affects 1 to 10 of 1000 users:
skin rash or allergic reaction on the skin, or hives (urticaria). Signs of this can be red, raised and itchy swellings;
changes in heart rate (heart rate) and changes in the results of the ECG (electrical recording of the heart);
abnormal involuntary movements such as twitching, numbness or muscle contraction.
If any of the side effects gets serious, or if you notice other effects not listed in this leaflet, please tell your doctor, nurse or pharmacist.

5. HOW TO STORE GRANEGIS
Keep out of reach of children.
Store in the original package in order to protect from light. Do not use Granegis film-coated tablets after the expiry date stated on the packaging after "EXP". The expiry date refers to the last day of that month.
Medicines should not be disposed of via wastewater or with household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. FURTHER INFORMATION
What Granegis
The active substance is granisetron.
Each tablet contains Granegis 1 mg 1 mg granisetron in the form of granizetronov hydrochloride.
Each tablet contains 2 mg Granegis 2 mg of granisetron in the form of granizetronov hydrochloride.

Other ingredients are:
Tablet core: anhydrous lactose, microcrystalline cellulose, sodium starch glycolate (type A), hypromellose, magnesium stearate.
Film Coating: Opadry II 85F 18378 white (polyvinyl alcohol, titanium dioxide (E171), macrogol 3350, talc).