IZOREKS 50 mg. / ml. 120 ml.

What IZOREKS and what is it used?
IZOREKS oral solution contains the active ingredient inosine atsedoben dimepranol, which is used for the treatment of certain viral infections. It is believed that its action is in the stimulation of the immune system so that it can fight the virus.
Your doctor has prescribed IZOREKS to stimulate your immune system to overcome the viral infection in the following cases:
a) As an immunomodulator in the treatment immunosuppressive conditions and persistent viral infections, subacute sclerosing panencephalitis as herpes simplex type 1 and 2;
b) For treatment of recurrent herpes simplex type 1 and 2;
c) In addition, in the treatment of genital warts.

2. What you should know before using IZOREKS
Do not take IZOREKS:
if you are allergic (hypersensitive) to inosine atsedoben dimepranol or any of the other ingredients of the oral solution (see the full list of ingredients in Section 6). An allergic reaction can be expressed in a rash, itching, difficulty breathing or swelling of the face, lips, throat or tongue;
if you suffer from gout or you have been informed that you have elevated levels of uric acid.
Warnings and Precautions
Talk to your doctor, pharmacist or nurse before taking IZOREKS:
if have a history of gout or elevated uric acid levels;
if you have a history of kidney stones or bladder;
if you suffer from kidney disease (you must be monitored).
Other medicines and IZOREKS
Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines.
Tell your doctor if you are taking drugs such as allopurinol or other medicines for gout; diuretics (water tablets); drugs that suppress the immune system, for example after an organ transplant; azidothymidine (a drug for the treatment of AIDS), as they may interact with IZOREKS.

Pregnancy, lactation and fertility
Ask your doctor or pharmacist before taking any medicine.
Do not take IZOREKS oral solution if you are pregnant or breast-feeding, unless specifically prescribed by your doctor.

Driving and using machines
IZOREKS is unlikely to affect your ability to drive or operate machinery.

3. How to take IZOREKS
Always use this medicine exactly as you have been told by your doctor. If you're not sure, ask your doctor or pharmacist.
The dosage depends on your body weight (no fat) and the severity of your condition. The daily dose is divided evenly.

Adults and elderly patients
The usual daily dose is 50 mg / kg - 100 mg / kg (body weight) normally 3 g daily inosine atsedoben dimepranol (20 ml x 3-4 times) to a maximum of 4 g per day.

Children over 1 year of age
The usual dose is 50 mg / kg body weight / day (10 ml per 10 kg to 20 kg; above this weight is used adult dose).

Dosage in subacute sclerosing panencephalitis (SSPE):
100 mg / kg body weight per day, but not more than 3-4 g, in regular monitoring of the patient's condition and the need for continuing treatment.

Dosage in patients with genital warts:
3 g (20 ml x 3 times a day) for a total of 14-28 days, in addition to conventional topical or surgical procedures, in accordance with the following timetables:
a) 14-28 days for low-risk patients *, allowing achieve maximum ratio clearing / recurrence of lesions for two months or more after treatment interruption, without application of any other medicine;
b) 5 days a week, 1-2 consecutive weeks per month, for 3 months in high risk patients (patients with immunodeficiency or those at high risk of relapse), achieving maximal ratio clearing / recurrence of the lesions by the end of the third month treatment.

* Profiles of patients at high risk for recurrence or cervical dysplasia or genital warts are similar to those of other diseases and include:
Genital diseases viral story> 2 years or> 3 unsuccessful previous therapies;
Immunosuppression resulting from:
recurring or chronic infections or other infections transmitted sexually;
anticancer chemotherapy;
chronic alcohol abuse;
Untreated diabetes;
Atopy;
Long-term use of oral contraceptives (2 years or more);
Folate concentration (salt / ester of folic acid) in erythrocytes <660 nmol / L;
Lack of a history of skin warts in childhood;
Multiple sexual partners or any change in longstanding partner;
Frequent vaginal sex (_> 2-6 times a week);
Anal sex;
Age (for each additional year over 20 + 3);
Prolonged smoking.
The dose and duration of administration are determined by the doctor.

If you take more dose IZOREKS
So far no reports of overdose. If you are unsure about something or you feel unwell, contact your doctor as soon as possible.

If you forget to take IZOREKS
If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not take a double dose to make up the missed dose.

If you have any further questions on the use of this product, ask your doctor, pharmacist or nurse.

4. Possible side effects
Like all medicines, IZOREKS can cause side effects, although not everybody gets them.

All medicines can cause allergic reactions, although serious allergic reactions are very rare.
Tell your doctor immediately if you experience:
sudden wheezing / wheezing;
difficulty breathing;
swelling of eyelids, face or lips;
rash or itching (especially affecting the whole body).
The following adverse drug reactions:
temporarily elevated levels of uric acid in the blood;
elevated liver enzymes and blood urea - is detected by a blood test by your doctor;
feelings of nausea with or without vomiting;
tummy ache;
itching;
rash (alone);
headache;
dizziness;
fatigue or feeling sick, pain in the joints;
diarrhea;
constipation;
nervousness;
drowsiness or sleep impossible;
increased amount of urine.
If you get any side effects, contact your doctor or pharmacist. This includes all listed in this leaflet.

5. How to store IZOREKS
Keep out of reach of children.
Does not require any special storage conditions.
Store in the original container and seal it.
Do not use IZOREKS after the expiry date stated on the carton and bottle after "EXP". The expiry date refers to the last day of that month.
Shelf life after first opening the bottle - 3 months.
Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.

6. Contents of the pack and further information
What IZOREKS
The active substance is inosine atsedoben dimepranol (metizoprinol)
The other ingredients are: sucrose, glycerol, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, citrus flavor, purified water.

IZOREKS looks like and contents of the pack
Clear, colorless liquid 50 mg / ml - 1 glass bottle 120 or 240 ml in a cardboard box accompanied by a dosing cup made of polypropylene with low density together with a leaflet.