KARBIS 16 mg. 30 tablets

WHAT KARBIS AND WHAT IT IS USED FOR?
Karbis belongs to the group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This leads to an increase in blood pressure. Karbis prevents the binding of angiotensin-II to these receptors, resulting in relaxation of blood vessels and blood pressure is lowered.
Karbis is used to treat high blood pressure (hypertension) and for the treatment of certain types of heart failure.
 
2. BEFORE YOU TAKE KARBIS
Do not take Karbis
- If you are allergic (hypersensitive) to candesartan cilexetil or any of the other ingredients of Karbis
- If you are more than 3 months pregnant. (It is also better to avoid Karbis in early pregnancy - see pregnancy section)
- If you have severe liver disease.
- Take special care with Karbis If you have excessive vomiting or diarrhea
- If you have heart problems, if you have kidney problems,
- If you are going to have surgery or receive anesthetics, you should tell your doctor that you are taking Karbis,
- You should tell your doctor if you think you are (or might become) pregnant. Karbis not recommended in early pregnancy and must not be taken if you are pregnant for more than three months, as it may cause serious harm to your baby if used at that stage (see point of Pregnancy). If you are breastfeeding or plan to breastfeed, you should tell your doctor.

Pregnancy and lactation
Consult your doctor or pharmacist before taking any medicine.
pregnancy
You should tell your doctor if you think you are (or might become) pregnant. Your doctor will normally advise you to stop taking Karbis before you become pregnant or as soon as you know is pregnant and will advise you to take another medicine instead Karbis. Karbis not recommended in early pregnancy and must not be taken if you are pregnant for more than three months, as it may cause serious harm to your baby if used after the third month of pregnancy.

breastfeeding
Tell your doctor if you are breastfeeding or plan to breastfeed. Karbis not recommended for mothers who are breastfeeding, and your doctor may choose another treatment for you if you want to breastfeed, especially if your baby is newborn, or was born prematurely.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
May require blood tests if you are taking:
• Potassium supplements,
• Potassium-containing salt substitutes,
• Potassium-sparing medicines that increase the amount of urine (diuretics), other medicinal products that may increase potassium levels (eg. Heparin)
• ACE inhibitor
• Non-steroidal anti-inflammatory drugs
• or lithium-containing medicines.
The effect of candesartan cilexetil may be reduced when you take NSAIDs (eg, ibuprofen).

Taking Karbis with food and drink
Karbis can be taken with or without food.

Driving and using machines
No studies on the effects on the ability to drive and use machines Karbis but Karbis is unlikely to affect your ability to drive or operate machinery. However, sometimes it can occur dizziness or fatigue during treatment of high blood pressure. If you have these symptoms, you should consult with your doctor before driving or operating machinery.

Important information about some of the ingredients of Karbis
Karbis contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact him before taking this product.

3. HOW TO TAKE KARBIS?
Always take Karbis exactly as your doctor has told you. You should consult with your doctor or pharmacist if you are not sure. There are other levels available that may be more appropriate to your dosing schedule.
Karbis taken orally and can be taken with or without food once a day. You should try to take your daily dose at the same time each day. It is important to continue taking the tablets until the doctor tells you otherwise.
Adults: The usual dose is 8 mg once daily. The dose may be increased to 32 mg once a day depending on the blood pressure response.
The maximum effect of lowering blood pressure to be achieved 4 weeks after beginning treatment.
Children: Karbis usually not recommended for children (<18 years).
Patients with kidney problems Your doctor may recommend a lower dose, especially when starting treatment.
Patients with liver problems: Your doctor may recommend a lower dose, especially when starting treatment.
If you take more Karbis, must OTKOLKOTO
If you accidentally take too many tablets, or a child swallows some, contact your doctor immediately.

If you forget to take Karbis
If you accidentally miss a daily dose, just take your next dose as usual. Do not take a double dose to make up the missed dose.

If you stop taking Karbis
If you stop taking Karbis your blood pressure may increase again. Therefore you should not stop taking Karbis without first consulting your doctor.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Like all medicines, Karbis can cause side effects, although not everybody gets them.
If side effects occur, they are usually mild and temporary. However, some effects may be serious and may require medical attention.
Presentation of the frequency of adverse reactions described in this section:
Very common: affects more than 1 user in 10
Common: affects 1 to 10 users in 100
Uncommon: affects 1 to 10 users in 1000
Rare: affects 1 to 10 users in 10,000
Very rare: affects less than 1 user in 10,000
Not known frequency can not be made from the available data
As with similar medicines, rare cases of allergic skin reactions (rash, urticaria), as well as localized swelling of the face, lips and / or tongue have been reported in patients receiving candesartan cilexetil. If you think you have developed such a reaction or get short of breath, stop taking Karbis and seek immediate medical attention.
The following adverse reactions have been reported in patients with high blood pressure in clinical studies:
Common: chills or flu-like symptoms, dizziness / vertigo and headaches.
In patients with heart failure * The following additional adverse reactions were reported in clinical trials:
Common: low blood pressure, elevated blood potassium and kidney problems.
Adverse reactions reported after the marketing of candesartan cilexetil are:
Very rare side effects: headache, dizziness, decreased number of white blood cells, nausea, pain in joints and muscles, abnormal liver function, renal function, increased levels of potassium in the blood, reducing blood levels of sodium.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist

5. HOW TO STORE KARBIS?
Keep out of the reach and sight of children.
Karbis not use after the expiry date stated on the pack
The expiry date refers to the last day of that month.
This medicinal product does not require any special storage precautions.
Medicines should not be disposed of via wastewater or household waste.

6. FURTHER INFORMATION
What Karbis?
The active substance is candesartan cilexetil (candesartan cilexetil). Each tablet contains 4 mg, 8 mg, 16 mg or 32 mg of candesartan cilexetil. The other ingredients are lactose monohydrate, maize starch, macrogol 8000, hydroxypropyl cellulose, carmellose calcium, magnesium stearate and iron oxide red (E 172) - (only tablets of 8 mg, 16 mg and 32 mg)