KARDIFREND table. 5 mg

KARDIFREND WHAT IS AND WHAT IT IS USED

Kardifrend contains a medicine called ramipril. It belongs to a group of drugs called ACE inhibitors (angiotensin converting enzyme).

Kardifrend acts as:

 Reduces your body's production of substances that can increase blood pressure

 Helps to relax and widen your blood vessels

 It helps the heart to pump blood around your body

Kardifrend can be used:

 For the treatment of high blood pressure (hypertension)

 To reduce the risk of getting a heart attack or stroke

 To reduce the risk or delay the worsening of kidney problems (if you have or have diabetes)

 For the treatment of heart when it carpets to pump enough blood to the body (heart failure)

 As a treatment after a heart attack (myocardial infarction) complicated with heart failure

 BEFORE YOU TAKE KARDIFREND

Do not take Kardifrend

 if you are allergic (hypersensitive) to ramipril or any other drug - ACE or any of the other ingredients of Kardifrend listed in section 6.

 Signs of an allergic reaction may include hives, difficulty breathing or swallowing, swelling of the lips, face, throat or tongue.

 if you have ever had a serious allergic reaction called "angioedema". Signs include itching, hives (urticaria), redness of the hands, feet and throat, swelling of the throat and tongue, swelling around the eyes and lips, difficulty in breathing and swallowing

 if you are on dialysis or nyaakav another type of blood filtration. Depending on the equipment used, Kardifrend may not be suitable for you

 If you have kidney problems where the blood supply to the kidneys is reduced (renal artery stenosis)

 During the last six months of pregnancy (see section below on "Pregnancy and Lactation")

 If your blood pressure is abnormally low or unstable. Your doctor will need to make this assessment.

Do not take Kardifrend if any of the above apply to you. If you're not sure, ask your doctor before taking Kardifrend.

Take special care with Kardifrend

Ask your doctor or pharmacist before taking your medicine:

if you have heart problems, liver or kidney;

 If you've lost a lot of body fluids and salts (from vomiting, diarrhea, sweating more than usual, if you are on a diet low in salt if you are taking diuretics (water) for a long time and have been on dialysis);

 if you are undergoing treatment for reducing allergy to stings from bees or wasps (desensitization);

 If you are going anesthesia. It can be given for an operation or dental work. You may need to stop treatment with Kardifrend one day earlier, ask your doctor for advice.;

 If you have high amounts of potassium in the blood (shown in the results of blood tests);

 If you have a collagen vascular disease such as scleroderma or systemic lupus erythematosus;

 You must tell your doctor if you think you are (or might become) pregnant.

Kardifrend not recommended during the first three months of pregnancy and may cause serious harm to your baby after the third month of pregnancy (see section "Pregnancy and Lactation").

Children:

Kardifrend not recommended for use in children and adolescents under the age of 18 because the drug has never been used in this age group.

If any of the above apply to you (or not sure), talk to your doctor before taking Kardifrend.

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription (including herbal medicines). Kardifrend can affect the operation of some other drugs. As some medicines can affect the way a Kardifrend.

Please consult your doctor if you are taking any of these medicines. They can weaken the effect of Kardifrend:

 Medicines used to relieve pain and inflammation (eg, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or indomethacin and aspirin);

 Medicines used to treat low blood pressure, shock, heart failure, asthma or allergies such as ephedrine, epinephrine or norepinephrine. Your doctor will need to check your blood pressure;

Tell your doctor if you are taking any of these medications. They can increase the chance of getting side effects if you take them with Kardifrend:

 Medicines used to relieve pain and inflammation (eg, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or indomethacin and aspirin);

 Medicines used to treat cancer (chemotherapy);

 medicines used to prevent organ rejection after a transplant such as cyclosporine;

 Diuretics (water pills) such as furosemide;

 Drugs that may increase the amount of potassium in the blood such as triamterene, amiloride, potassium salts and heparin (blood thinning);

 Steroid medicines for inflammation like prednisone;

 Allopurinol (used to reduce uric acid in your blood);

 Procainamide (for heart rhythm disorders)

Tell your doctor if you are taking any of these lekarstva.Te can be influenced by Kardifrend:

 Medicines for diabetes, lowering blood sugar, which is taken orally and insulin. Kardifrend can lower your blood sugar. Check your blood sugar closely while taking Kardifrend;

 Lithium (for mental health problems). Kardifrend can increase the amount of lithium in your blood. The amount of lithium should be monitored closely by your doctor.

If any of the above apply to you (or not sure), talk to your doctor before taking Kardifrend.

Taking Kardifrend with food and drink

 The use of alcohol Kardifrend can cause dizziness and fainting. If you take Kardifrend discuss with your doctor how much you can drink as medicines used to lower blood pressure and alcohol can have additive effects.

 Kardifrend can be taken with or without food.

Pregnancy and Lactation

You must tell your doctor if you think you are (or might become) pregnant. You should not take Kardifrend during the first 12 weeks of pregnancy, and you should not take it after the 13th week as possible use during pregnancy can harm the baby. If you become pregnant while taking Kardifrend, tell your doctor. It must be done switching to alternative therapy a planned pregnancy. You should not breastfeed if Kardifrend.

Ask your doctor or pharmacist before taking any medicine.

Driving and operating machinery

You may feel dizzy while taking Kardifrend. Is more likely to happen at the beginning of treatment Kardifrend or if taking a higher dose. If this happens, do not drive or use any tools or machines.

 HOW TO TAKE KARDIFREND

Always Kardifrend exactly as your doctor tells you. If you're not sure, ask your doctor or pharmacist.

Taking this medicine

 Take this medicine by mouth at the same time each day.

 Swallow the tablets whole with liquid.

 Do not crush or chew the tablets

How much to take

Treatment of high blood pressure

 The usual starting dose is 2.5 mg once daily.

 Your doctor will adjust the dose until your blood pressure is not well controlled

 The maximum dose is 10 mg once daily.

 If you are already taking diuretics (water tablets), your doctor may stop or reduce the amount of diuretic you take before beginning treatment with Kardifrend.

To reduce the risk of heart attack or stroke

 The usual starting dose is 2.5 mg once daily.

 Your doctor may then decide to increase the amount you take.

 The usual dose is 10 mg once dnebno.

Treatment to reduce or delay the worsening of kidney problems

 You can start with a dose of 2.5 mg once daily.

Your doctor will adjust the amount you take

 The usual dose is 5 mg or 10 mg once daily.

Treatment of Heart Failure

 The usual starting dose is 2.5 mg once daily.

 Your doctor will adjust the amount you take

 The maximum dose is 10 mg. Preferably twice a day.

Treatment then had a heart attack

 The usual starting dose is 2.5 mg twice daily

 Your doctor will adjust the amount you take

 The usual dose is 10 mg dnebno. Preferably twice a day.

Elderly

Your doctor will reduce the initial dose and adjust the dose more slowly.

If you take more than the dose Kardifrend

Contact your doctor or go to the nearest hospital casualty department. Do not drive to the hospital, get somebody else to take you or call an ambulance. Take the medicine pack with you to the doctor to understand what you have.

If you forget to take Kardifrend

 If you miss a dose, take your normal dose when it is next

 Do not take dboyna dose to make up for a forgotten tablet.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

 POSSIBLE SIDE EFFECTS

Like all medicines, Kardifrend can cause side effects, although not everybody gets them.

Stop taking Kardifrend and see a doctor immediately if you notice any of the following serious side effects - you may need urgent medical treatment:

 Swelling of the face, lips or throat which make it difficult to swallow or breathe, as well as itching and rash. This may be a sign of a severe allergic reaction to Kardifrend.

 Severe skin reactions including rash, mouth ulcers, worsening of pre-existing skin disease, redness, blistering or peeling of the skin (such as Stevens-Johnson syndrome, toxic epidermal necrolysis and erythema multiforme).

Immediately contact your doctor if you:

 Increased heart rate, uneven or forceful heartbeat (palpitations), chest pain, chest tightness, or more serious problems, including heart attack and stroke

 Shortness of breath or cough. These may be signs of lung problems

 For easier bruising, bleeding longer any bleeding (eg, bleeding gums), purple spots covering skin more easily susceptible to infections, sore throat, fever, fatigue, dizziness or pale skin. These can be signs of problems with blood or bone marrow.

Severe stomach pain which may reach through to your back .. This may be a sign of pancreatitis (inflammation of the pancreas).

Fever, chills, tiredness, loss of appetite, stomach pain, nausea, yellowing of the skin or eyes (jaundice). These may be signs of liver problems such as hepatitis (inflammation of the liver) or liver damage.

Other side effects include:

Tell your doctor if any of the following gets serious or lasts longer than a few days.

Common (affects less than 1 in 10 people)

 Headache or tiredness

 Feeling dizzy. Is more likely to happen in home Kardifrend intake or increasing the dose.

 Fainting, hypotension (abnormally low blood pressure), especially when getting up from a lying or sitting position.

 Dry tickly cough, inflammation of the sinuses (sinusitis) or bronchitis, shortness of breath

 Stomach or intestinal pain, diarrhea, indigestion, nausea or vomiting

 Skin rash with or without edema

 Chest pain

 Cramps or muscle pain

 Blood tests showing high levels of potassium in the blood.

Uncommon (affects less than 1 in 100 people)

 Impaired balance (vertigo)

 Itching and unusual skin sensations such as numbness, tingling, pricking, burning or creeping on the skin (paraesthesia)

 Loss or change in taste

 Sleep problems

 Feeling depressed, anxious, nervous or greater uncertainty than usual

 Stuffy nose, difficulty breathing or worsening of asthma

Swelling of the intestines called "intestinal angioedema", with symptoms such as abdominal pain, vomiting and diarrhea

 Heartburn, constipation or dry mouth

 Passing more urine than usual day

 More Sweating more than usual

 Loss or decrease of appetite (anorexia)

Fast or irregular heartbeat. Swollen hands and feet. This may be a sign of a more fluid retention in the body.

 Flushing

 Blurred vision

 Joint pain

 Fever

Sexual inability in men, decreased sexual desire in men and women

 Increased number of certain white blood cells (eosinophilia), detected in blood tests

 Blood tests showing changes in the liver, pancreas and kidneys

Rare (affects less than 1 in 1000 people)

 Feelings of uncertainty or confusion

 Red and swollen tongue

 Severe flaking or peeling of the skin, itchy, bumpy rash

 Nail problems (eg, loss or separation of a nail from its bed)

 Skin rash or bruising

Stains on the skin and cold extremities

Red, itchy, swollen or watery eyes

 Impaired hearing or ringing in ears

 Feeling of weakness

 Blood tests showing a reduction in red blood cells, white blood cells or platelets, or the amount of hemoglobin.

Very rare (affects 1 in 10,000 people)

 Increased sensitivity to sunlight than usual

Other side effects reported

Tell your doctor if any of the following gets serious or lasts longer than a few days.

 Difficulty concentrating

 Swollen lips

 Blood tests showing too few blood cells in the blood

 Blood tests showing less than normal amount of sodium in the blood

 discoloration of the fingers and toes when cold and then tingling or painful when you warm up (Raynaud's phenomenon)

 Breast enlargement in men

 Slowed or impaired reactions

 burning sensation

 Change in sense of smell

 Hair Loss

If you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.

 HOW TO STORE KARDIFREND

Keep out of reach of children.

Do not store above 25 ° C.

Store in the original package to protect from moisture.

Kardifrend Do not use after the expiry date stated on the carton and blister. The expiry date refers to the last day of that month.

Medicines should not be disposed of via wastewater or household waste.

Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.