L - thyroxine. 0.100 mg. 100 tablets

What is L- Thyroxine 100 Berlin - Chemie and what it is used?

L- Thyroxine 100 Berlin - Chemie contain synthetic levothyroxine - thyroid hormone .

L- Thyroxine 100 Berlin - Chemie is used for:

- Replace the missing thyroid hormone for all types of underactive thyroid gland ( hypothyroidism ) ;

- Prevention of recurrence of goitre after surgery goiter with normal thyroid function ;

- Treatment of benign goiter with normal thyroid function ; concomitant use of drugs that inhibit the activity of the thyroid gland ( thyreostatics ) with overactive gland ( hyperthyroidism ) , once it has reached a normal metabolic state ;

- Cancer of the thyroid gland , preferably after surgery for tumor growth inhibition , and replacing the missing thyroid hormone ; thyroid suppression test .

2 . Before taking L- Thyroxine 100 Berlin - Chemie

Do not take L- Thyroxine 100 Berlin - Chemie

- If you are allergic ( hypersensitive) to levothyroxine sodium or any of the other ingredients of L- Thyroxine 100 Berlin - Chemie ;

- In any form of untreated overactive thyroid gland ( hyperthyroidism ) ;

- In recent myocardial infarction , acute inflammation of the heart muscle insufficiency in untreated adrenal cortex and pituitary disorders , unless explicitly allowed the doctor application ;

- If you are pregnant and during this pregnancy taking medicines that inhibit the increased thyroid function ( thyreostatics ) ( see " Pregnancy and lactation " ) .

Take special care with L- Thyroxine 100 Berlin - Chemie

Before treatment with L- Thyroxine 100 Berlin - Chemie, should exclude the following diseases: coronary artery disease (e.g., angina pectoris ) , hypertension , impaired function of the pituitary gland or the adrenal cortex and the presence of areas of the thyroid gland , which autonomously produces thyroid hormones . In coronary artery disease , heart failure or abnormal heart rhythm with increased heart rate , should be avoided in all circumstances, even a slight increase in thyroid gland ( hyperthyroidism ) induced by levothyroxine .

In underactive thyroid gland disorder due to a pituitary must determine whether there is also a reduced function of the adrenal cortex . If necessary, this condition should be treated before starting therapy with thyroid hormone.

If you postmenopausal woman with hypothyroidism , and increased risk of osteoporosis, thyroid function must be controlled more frequently , in order to avoid increased levels of levothyroxine in the blood.

For example, if you are patient on hemodialysis and treated with sevelamer drug in the context of very high levels of phosphate in the blood , your doctor may monitor certain parameters in the blood of the effectiveness of levothyroxine ( see " Taking other medicines") .

In elderly patients need careful dosing and frequent consultation with a doctor.

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Amplify the effect of L- Thyroxine 100 Berlin - Chemie to an increased risk of side effects

Salicylates ( medicines against fever and pain ) , dicumarol ( a drug that inhibits the blood coagulation ) , high doses of furosemide ( a drug that increases urination) (250 mg), clofibrate ( a drug that reduces the levels of lipids in the blood) and other substances may increase blood levels of levothyroxine .

The rapid intravenous administration of phenytoin may lead to increased blood levels of thyroid hormone , and to contribute to the onset of an abnormal heart rhythm .

Weaken the effect of L- Thyroxine 100 Berlin - Chemie

Cholestyramine or colestipol (medicines to lower blood lipids ) inhibit the absorption of levothyroxine from the intestines and therefore should be taken 4-5 hours after L- Thyroxine 100 Berlin - Chemie .

Levothyroxine absorption from the gut may be reduced by concomitant administration of aluminum - containing antacids connecting stomach acid medicines containing calcium carbonate and iron. Therefore L- Thyroxine 100 Berlin - Chemie should be taken at least two hours prior to administration of these drugs. Propylthiouracil ( antithyroid ) , glucocorticoids ( hormones of the adrenal cortex ) , beta-blockers (medicines to lower high blood pressure) and iodinated contrast media can inhibit the conversion of levothyroxine in the effective form ( CA) thyroid hormone .

Sertraline ( medicine for depression ) and chloroquine / proguanil ( medicine against malaria and rheumatic diseases) decrease the effectiveness of levothyroxine . Barbiturates ( certain hypnotics) and certain other medicines may increase the breakdown of levothyroxine in the liver.

Needs of levothyroxine may increase during hormonal drugs for contraception or hormone replacement therapy at menopause.

Sevelamer ( a medicament for lowering elevated levels of phosphate in the blood of dialysis patients) may reduce the absorption and efficacy of levothyroxine . Therefore L- Thyroxine 100 Berlin - Chemie must be taken at least 1 hour before or 3 hours after sevelamer intake . Your doctor will monitor thyroid function more frequently ( see " Take special care with L- Thyroxine 100 Berlin - Chemie " ) .

Other possible interactions

Amiodarone (a medicine to treat abnormal heart rhythms ) due to the high content of iodine can cause both hyperthyroidism and hypothyroidism. Particular care is needed for the crop with knotted Genre areas producing hormones ( autonomy ) .

Levothyroxine may increase the effects of other drugs that inhibit blood clotting ( coumarin derivatives ) and reduce the effect of medicines that lower blood sugar. When concomitant treatment with these drugs and levothyroxine , especially in the beginning , your doctor will monitor the parameters of coagulation and blood glucose levels and , if necessary, adjust the dose of drugs that inhibit blood clotting or medicines to lower blood sugar.

Taking L- Thyroxine 100 Berlin - Chemie with other drugs

Products containing soy can impair levothyroxine absorption from the gut . At the beginning and at the end of a diet consisting of soy bean, it may be necessary adjusting the dose of L- Thyroxine 100 Berlin - Chemie .

Pregnancy and lactation

Ask your doctor or pharmacist before taking any medicine.

Continuous replacement therapy with thyroid hormone is particularly important during pregnancy and lactation and should therefore be continued. Despite the widespread use during pregnancy has risks to the fetus are not known. The amount of thyroid hormones that are secreted in human milk , even when treated with high doses of levothyroxine is very low and safe .

The needs of levothyroxine can be increased during pregnancy in women with hypothyroidism due to high levels of estrogen (female hormone ) in the blood . Therefore, thyroid function should be monitored both during the pregnancy and then the dose of thyroid hormone should be corrected .

However L- Thyroxine 100 Berlin - Chemie should not be co-administered with drugs that inhibit the increased thyroid function ( thyreostatics ) during pregnancy . This can lead to a greater demand of antithyroid . Unlike levothyroxine thyreostatics can reach the circulation of the fetus through the placenta and can lead to fetal hypothyroidism . Therefore, during pregnancy the treatment of hyperthyroidism must be carried out with lower doses thyreostatics .

During pregnancy should be made thyroid suppression test .

During pregnancy and lactation should be strictly dose prescribed by the physician and should not be exceeded.

3 . How to take L- Thyroxine 100 Berlin - Chemie ?

Always take L- Thyroxine 100 Berlin - Chemie exactly as your doctor tells you . If you are not sure, ask your doctor or pharmacist.

Individual daily dose should be determined by laboratory and clinical studies. Treatment with thyroid hormone should be initiated with caution in elderly patients with coronary heart disease or with severe or prolonged hypothyroidism. This means that you need to choose a lower starting dose slowly increased to longer intervals in frequent monitoring of thyroid hormones. Experience has shown that low doses are sufficient and low body weight and a large gnarled enough.
dosage
The usual dose is:
application
 Dose ( micrograms / day)
hypothyroidism :
Adults ( Increased intervals of 2-4 weeks with 25-50 micrograms)
Home
maintenance
25-50
100-200
Prevention of recurrence of goitre after surgery goitre 75-200

Benign goiter with normal thyroid function 75-200

Concomitant therapy with thyreostatics with hyperthyroidism 50-100

Thyroid suppression test 200 micrograms / day ( for 14 days prior to scintigraphy )

After surgery due malignant tumor of the thyroid 150-300

In children , treatment is started with a maximum dose of Vi tablet L- Thyroxine 100 Belin - Chemie daily ( equivalent to 50 micrograms of levothyroxine sodium daily) ; in neonates with a maximum of ½ tablet L- Thyroxine 100 Belin - Chemie daily ( equivalent to 50 micrograms of levothyroxine sodium).

With prolonged treatment, the dose is determined by other factors , and the age and weight of each child.

The table shows the most commonly used dose in replacement therapy in neonates and children :
Age Dose micrograms / day dose micrograms / kg / deH
0-6 months 25-50 10-15
6-24 months 50-75 8-10
2-10 years 75-125 4-6
10-16 years
100-200 3-4
> 16 years 100-200 2-3
In neonates deficient thyroid hormone is very important to start treatment as early as possible to achieve normal mental and physical development. Levothyroxine levels in the blood must be kept at the upper limit of normal in the first 3-4 years of life. In the first six months of life measurement of levothyroxine in the blood is more reliable control method compared to the levels of TSH ( thyroid stimulating hormone ) in the blood . Regardless of the optimal intake of levothyroxine to normalize TSH levels in some cases can last up to two years .

If necessary, it is recommended that application of a dose of a lower amount of active substance to the initiation of therapy , and to increase the dose in adults as well as for treatment of children .

Instructions for dividing the tablet

Put the tablet on a hard, flat surface , such as the score remain the top . Then press your finger vertically upper side of the tablet and you will get two equal halves of the tablet.
If you feel that the effect of L- Thyroxine 100 Berlin - Chemie is too strong or too weak, talk to your doctor.

Method of administration

The overall daily dose is administered in one portion with sufficient fluid in the fasted state for at least half an hour before breakfast .

Children take the full daily dose once at least half an hour before the first meal of the day. Therefore , the tablets were dissolved in a little water to give a fine suspension which was prepared immediately before administration and provides the child with additional liquid.

Duration of treatment

In hypothyroidism : usually a lifetime.

For prevention of recurrence of goiter : a few months to years or a lifetime. In euthyroid goitre : a few months to years or a lifetime. For the treatment of euthyroid goitre are needed from 6 months to 2 years. If during this period to achieve effect with L- Thyroxine 100 Berlin - Chemie, you need to take other therapeutic options .

In adjunctive therapy treatment of hyperthyroidism : the length of Thyrostatic therapy.

In operation thyroid cancer cause : usually a lifetime.

The duration of treatment is determined by the doctor .

If you take more than the amount of L- Thyroxine 100 Berlin - Chemie

In case of overdose can occur typical signs of hyperthyroidism include palpitations , irregular heartbeat, tightness in the chest ( angina pectoris ) , muscle weakness and muscle cramps , flushing , diaphoresis , fever , tremor of the fingers, a subjective feeling anxiety , insomnia, weight loss, vomiting , diarrhea, menstrual disorders , headache, increased brain pressure.
Tell your doctor if occurring on these complaints.

If you forget to take L- Thyroxine 100 Berlin - Chemie

If you miss a dose, do not double dose to compensate . Continue with normal regimen .

If you stop taking L- Thyroxine 100 Berlin - Chemie

Successful treatment requires regular use of prescribed dose L- Thyroxine 100 Berlin - Chemie . In case of withdrawal or premature discontinuation of treatment may be expected again a manifestation of grievances which are determined by the underlying disease .

If you have any further questions on the use of this product , ask your doctor or pharmacist.

4 . Possible side effects

Like all medicines , L- Thyroxine 100 Berlin - Chemie can cause side effects, although not everybody gets them .

In the assessment of adverse reactions taken the following frequencies :

Very common: affects more than 1 in 10 patients treated

Common: affects 1 to 10 users in 100 patients treated

Uncommon: affects 1 to 10 of 1000 patients treated

Rare: affects 1 to 10 of 10 000 patients treated

Very rare: less than 1 in 10 000 patients treated ( frequency can not be estimated from the available data)
Upon proper application of L- Thyroxine 100 Berlin - Chemie are expected side effects .
If in isolated cases, the dose is not well tolerated or overdosage , especially in very sharp increase in dose at the beginning of treatment may appear typical signs of hyperthyroidism ( palpitations, irregular heartbeat , tightness in the chest ( angina pectoris ) muscle weakness and muscle cramps, hot flashes, profuse sweating , fever , tremor of the fingers, subjective anxiety, insomnia , weight loss , vomiting , diarrhea, menstrual disorders , headache, increased brain pressure) (see " If you take more than the amount of L- Thyroxine 100 Berlin - Chemie " ) .

In this case, after consultation with your doctor , the daily dose should be reduced or treatment discontinued for several days. Immediately upon resolution of adverse effects , treatment can be continued with careful dosing.

In hypersensitivity to levothyroxine or any of the other ingredients may have allergic reactions such as urticaria, bronchial muscle spasm with shortness of breath (bronchospasm ), and laryngeal edema . In isolated cases, described the event of a severe allergic shock . In the event of hypersensitivity reactions , please see a doctor immediately .

If any of the side effects gets serious, or you notice other effects not listed in this leaflet , please tell your doctor or pharmacist.

5 . How to store L- Thyroxine 100 Berlin - Chemie ?

Keep out of reach of children!

Do not use L- Thyroxine 100 Berlin - Chemie after the expiry date stated on the carton. The expiry date refers to the last day of that month.

Store at temperatures below 25 ° C.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required . These measures will help to protect the environment.

6 . Additional Information

What does L- Thyroxine 100 Berlin - Chemie ?

The active substance is levothyroxine sodium (levothyroxine sodium). One tablet contains from 106.4 to 113.6 micrograms of levothyroxine sodium x H ₂ O (equivalent to 100 micrograms of levothyroxine sodium).

Other ingredients are: calcium hydrogen phosphate dihydrate, microcrystalline cellulose , sodium starch glycolate (type A) (Ph. Eur.), Dextrin , long chain glycerides.

Looks like L- Thyroxine 100 Berlin - Chemie and contents of the pack ?

L- Thyroxine 100 Berlin - Chemie are off-white to light beige , round, slightly rounded tablets scored on one side and marked " 100" on the other side.

L- Thyroxine 100 Berlin - Chemie is in original packs of 25, 50 or 100 tablets.