Lactulose - MIP 500 ml.

What is Lactulose-MIP and 65 g / 100 ml syrup is and what it is used
Lactulose-MIP contains lactulose (disaccharide), which is not degraded by enzymes in the small intestine and reaches the large intestine undigested in. Intestinal bacteria transformed lactulose to low molecular weight organic acids acidified medium and increase the volume of the intestinal contents. This leads to stimulation of peristalsis (rhythmic contraction of smooth muscles of the colon) and form soft stools.

What is Lactulose-MIP and 65 g / 100 ml syrup?
Without prescription for the treatment of constipation, which is not affected by diet and / or other recommended hygiene and dietary regulation of the physiological rhythm of the colon;
In need of soft stools (haemorrhoidal disease, colon surgery);
For prevention and treatment of hepatic encephalopathy (a disorder of brain activity in impaired activity of the liver). In this case, treatment must be under medical supervision.
2. Before you take Lactulose-MIP and 65 g / 100 ml syrup
Do not take Lactulose-MIP and 65 g / 100 ml syrup if you are:
Hypersensitive (allergic) to any of the ingredients;
If you suffer from intestinal patency (a condition characterized by severe abdominal pain, fever and impaired general condition);
If you have galactose intolerance;
If you have acute inflammatory gastrointestinal diseases (ulcerative colitis, Crohn's disease);
If you have disorders of fluid and electrolyte balance (pronounced loss of fluids and salts).
Take special care with Lactulose-MIP and 65 g / 100 ml syrup
If you suffer from prolonged constipation, you should consult a doctor before starting treatment with Lactulose-MIP and 65 g / 100 ml syrup because this condition may be a symptom of a more serious illness.

Information for patients suffering from diabetes and other disorders of carbohydrate metabolism
In 15 ml-MIP Lactulose 65 g / 100 ml syrup contains a small amount of easily-digestible carbohydrates (fructose <1 g, lactose <10 g, galactose <15 g in 100 ml). They are absorbed by the body in very small extent, so have almost no nutritional value.)
Due to the content of fructose and galactose, the drug should not be used by patients with lactase deficiency, galactosemia and glucose / galactose malabsorption syndrome (congenital condition characterized by disturbances in the digestion of carbohydrates).

Children
Children above disorders in carbohydrate metabolism may not have been diagnosed yet, which is why treatment with Lactulose-MIP and 65 g / 100 ml syrup in them should be initiated after consulting a doctor.

If you are taking other medicines
Lactulose may increase the loss of electrolytes (especially potassium) caused by other medicines, such as diuretics, corticosteroids and some antibiotics to treat fungal infections. Note that the reduced level of potassium in the body increases the sensitivity to certain medications, especially cardiac glycosides (medicines for the treatment of arrhythmias and heart failure). Lactulose may limit the effect of drugs whose action is dependent on a specified level of intestinal pH (eg. Derivatives of 5-aminosalicylic acid and sulfasalazine mesalazine).
Therefore, tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Taking Lactulose-MIP and 65 g / 100 ml syrup with food and alcoholic beverages
Lactulose-MIP and 65 g / 100 ml syrup can be taken at any time, regardless of the hours of nutrition and food. It is easier to accept and absorb liquid such as water, fruit juice, tea, coffee, yogurt, as well as slurries.

Pregnancy and lactation
Lactulose-MIP and 65 g / 100 ml syrup can be used safely during pregnancy and lactation, provided it is used according to directions.

Effects on ability to drive and use machines
Lactulose-MIP and 65 g / 100 ml syrup does not affect ability to drive and use machines.

3. How to take Lactulose-MIP and 65 g / 100 ml syrup
Always take Lactulose-MIP and 65 g / 100 ml syrup just as you have been told by your doctor. You should check with your doctor if you are not sure.

Unless your doctor advises otherwise, the usual dose is as follows:
Constipation:
The dosage is determined individually and depends on the severity of constipation. The daily dose listed in the following table are distributed 1-2 doses.

Initial dosage (3-4 days) Maintenance dosage
Mature
10 -45 ml 10-25 ml
Children 7-14 on
15 ml 10-15 ml
Children 1-6, the
5-10 ml 5-10 ml
Infants 5 ml 5 ml

In general, the dosage may be reduced after a few days, depending on the individual needs of the patient. The duration of treatment with Lactulose-MIP and 65 g / 100 ml syrup is individual.
Laxative effect occurs 2 to 10 hours after taking the drug. If the dose is inadequate, the first defecation may occur after 24-48 hours. If after the first two days no improvement can try a higher dose.

In liver failure
The dose should be increased gradually.
Adults:
After an initial daily dose of 10-15 ml-MIP Lactulose 65 g / 100 ml of syrup, the dosage should be increased to 30-45 ml, divided into 3 to 4 times daily.
The dose should be adjusted so as to achieve double or triple passing of soft stools each day.

Children:
Not recommended for use in children with liver disease.

Important!
Lactulose-MIP 65 g / 100 ml of syrup is not addictive.

Overdose!
No evidence of overdose. At higher than recommended dosages can occur abdominal pain and diarrhea. In such cases, a discontinuation of treatment.

Route of administration:
Lactulose-MIP and 65 g / 100 ml syrup taken with his measuring cup. When a single daily dose of Lactulose-MIP and 65 g / 100 ml syrup is sufficient to treat constipation, it was found that its application morning after breakfast tolerated best.

4. Possible side effects
As with any drug Lactulose-MIP and 65 g / 100 ml syrup can cause side effects, although not everybody gets them.
If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.
In rare cases, in the first days of treatment, increases the formation of intestinal gas (flatulence). As a rule it disappears in a few days. Abdominal pain and diarrhea may occur in the administration of doses higher than prescribed. In such cases the dose should be reduced and seek a doctor's advice. With continued use Lactulose-MIP can cause electrolyte imbalance.

What other drugs influence the effects of lactulose-MIP?
To avoid possible interactions between several drugs should regularly inform your doctor and pharmacist about any other medication you are taking right now!

Adverse reactions reported with the use of lactulose were evaluated by the following frequency classification:
Very common (> 1/10 patients); Common (> 1/100, <1/10 patients); Uncommon (> 1/1 000 to <1/100 patients); Rare (> 1/10 000 to <1/1 000 patients); very rare (<1/10 000 patients), not known (from the available data can not be estimated).
Within each frequency adverse reactions are presented in order of decreasing seriousness.

Adverse reactions with lactulose:
Gastrointestinal disorders:
Very common: in implementing the medium dose at the beginning of treatment may occur mild abdominal pain, flatulence (bloating) and flatulence (wind). Higher doses can cause nausea, vomiting, diarrhea, leading to fluid or electrolyte imbalance (expressed loss of fluids and salts).
Metabolism and nutrition disorders:
Rare: During the treatment of brain damage associated with chronic liver disease, is reported to increase the serum concentration of sodium;
Not known: Prolonged use of lactulose-MIP and 65 g / 100 ml syrup in high doses can lead to disorders of fluid and electrolyte balance (pronounced loss of fluids and salts) characteristic of drugs with laxative action.

5. Storage of lactulose-MIP and 65 g / 100 ml syrup
Store at 25 ° C. Keep away from direct sunlight!
Do not use after the expiry date stated on the packaging.
Shelf life after opening 6 months.

6. Further information
What Lactulose-MIP and 65 g / 100 ml syrup
The active substance is lactulose.
100 ml of syrup contain: Lactulose 65 g, and the fructose <1 g, lactose <10 g, galactose <15 g.
Other ingredients are: Citric acid (anhydrous) and purified water.