Lisinopril 10 mg. 30 tablets

What is Lisinopril Unifarm and what it is used for
Lisinopril Unifarm refers to a group of medicines called angiotensin-converting enzyme (ACE) inhibitors. It reduces blood pressure and peripheral vascular resistance, improves left and right ventricular heart function, increases heart rate and heart rate, reduces pulmonary stagnation.

Lisinopril is used to:

• treatment of high blood pressure, alone or in combination with other blood pressure lowering medications;
• treatment of heart failure in addition to cardiac glycosides and diuretics;
• prevent the development of left ventricular weakness (weakening of left ventricular heart function) and heart failure, improve survival in patients with acute myocardial infarction and maintain stable blood circulation in the first 24 hours;
• treatment of kidney complications in diabetes - kidney disease in patients with high blood pressure and type 2 diabetes and initial nephropathy.

2. What you need to know before taking Lisinopril Unipharm

Do not take Lisinopril Unipharm

if you are allergic (hypersensitive) to the active substance or to any of the other ingredients of this medicine (listed in section 6);
if you are hypersensitive to other medicines in this group (ACE inhibitors) if you have had angioneurotic edema (swelling of the face, lips, tongue, nasopharyngeal, limb) in pretreatment with ACE inhibitor
if you have diabetes or have impaired kidney function and are being treated with a blood pressure lowering medication containing aliskiren;
if you have recently had a heart attack (acute) with sudden changes in blood pressure;
if you have severe heart disease - narrowing of the aorta or mitral valve, hypertrophic cardiomyopathy;
if you have bilateral narrowing of the renal arteries or narrowing of the artery in a single kidney;
if you have a severe heart function disorder accompanied by a marked decrease in blood pressure (cardiogenic shock);
if you are on hemodialysis using high-permeable polyacrylonitrile membranes; if you have creatinine clearance values ​​above 220 umol / l;
during the last six months of pregnancy (the use of lisinopril is also not recommended during the first three months of pregnancy - see Pregnancy, Breastfeeding Fertility).
Warnings and precautions

Talk to your doctor or pharmacist before taking Lisinopril Unipharm

if there is a risk of severely lowering blood pressure due to impaired water-salt balance, e.g. treatment with diuretics (drainage medicines), dietary salt restriction or as a result of vomiting or diarrhea;
if you are taking any of the following medicines used to treat high blood pressure:
- angiotensin II receptor blocker (ARB) (also known as sartans - for example valsartan, telmisartan, irbesartan), especially if you have kidney problems associated with diabetes.
- aliskiren

Your doctor may periodically check your kidney function, blood pressure and the amount of electrolytes (eg potassium) in your blood.
See also the information titled "Do not take Lysinopril Unipharm."

if you have narrowing of the aorta (aortic stenosis), narrowing of the renal artery or increased thickness of the heart muscle (hypertrophic myocardiopathy); if you have a problem with your heart, liver or kidneys; if you have recently had kidney transplantation;
if you have had an allergic reaction in the past with swelling of the face, lips, tongue with difficulty swallowing or breathing;
if you have systemic diseases of the connective tissue, diabetes mellitus, any inflammatory diseases (inflammation of the throat, fever, etc.);
if you are taking allopurinol, procainamide or potassium-sparing diuretics, potassium supplements, potassium-containing salts and other medicines associated with increased potassium in the blood serum;
before surgery or anesthesia, tell your doctor that you are taking lisinopril as a sudden decrease in blood pressure may occur;
if you are going to have a desensitization treatment against insect poisoning (bees or axes). Desensitization treatment may sometimes increase the risk of anaphylactoid reactions with concomitant ACE inhibitors.
if you are going to have a treatment called LDL-apheresis with dextran sulphate (cleaning low-density lipoproteins with high cholesterol);
if you perform hemodialysis with high-permeable membranes (polyacrylonitrile);
if you think you are pregnant (or you may be pregnant). The use of Lisinopril Unipharm is not recommended during the first three months of pregnancy. The product should not be used after the third month of pregnancy, as it may cause serious harm to your baby if taken during this period (see section "Pregnancy, breast-feeding and fertility" below).
If any of the following symptoms occurs during treatment with Lisinopril Unipharm,
concomitant administration of indomethacin and other non-steroidal anti-inflammatory drugs may result in suppression of the treatment effect of lisinopril.
concomitant administration of the product with oral antidiabetic agents (sulphonylureas and biguanides) and insulin may increase their healing effect (lowering of blood sugar).
if you are taking anesthetics (narcotic drugs), drugs and hypnosis, tell the treating physician that you are taking lisinopril. There is a risk of a marked decrease in blood pressure.
sympathomimetics (sympathetic nervous system stimulants) reduce the action of lisinopril.
if you are being treated with gold-containing medicines while you are on a regular basis. lisinopril are possible nitrite reactions (expressed by facial flushing, dizziness and low blood pressure).
lisinopril may be co-administered with aspirin (acetylsalicylic acid at cardiac doses), thrombolytics (blood clotting medicines), beta blockers (medicines to treat certain heart conditions), and nitrates.
Lysinopril Unifarm with food, drinks and alcohol
There is no evidence of interactions with concomitant food intake. ACE inhibitors enhance the effect of alcohol. Co-administration of lisinopril with alcoholic products is not recommended.

Pregnancy, breastfeeding and fertility

If you are pregnant or breast-feeding, think you may be pregnant or planning to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.

Pregnancy
The use of lisinopril is not recommended during the first three months of pregnancy.
If you are pregnant, plan a pregnancy or suspect that you are pregnant, please consult
talk to your doctor to change your treatment.
Lysinopril should not be used during the last six months of pregnancy because
can cause serious harm to your baby.

Breastfeeding
The use of lisinopril is not recommended by mothers of preterm infants as well as during the first few weeks after birth.
Driving with machines
Lysinopril Unipharm may cause dizziness and vertigo in some patients. Close monitoring of such symptoms is necessary. Do not take action that requires active attention when they occur.

3. How to take Lisinopril Unipharm
Always take this medicine exactly as your doctor has told you. If you are not sure ask your doctor or pharmacist.
Follow exactly the recommended dosage and route of administration. The medicine is taken once a day before, during or after a meal. Food does not affect its absorption. Take the tablets with a sufficient amount of liquid.

Adults
The usual dose is between 5 and 40 mg, depending on your disease and response to treatment. If you have a kidney function disorder, your doctor will prescribe a lower dose than usual.

Use in children and adolescents
Depression from 6 to 16 years of age with hypertension (elevated blood pressure) The recommended starting dose is 2.5 mg once daily in children weighing 20 to 50 kg and 5 mg once daily in children weighing more than 50 kg. In children with impaired renal function, the physician will prescribe a lower dose or lisinopril intake at longer intervals.

If you take more than the required dose of Luzinopril Unipharm
If you take a dose higher than prescribed, call your doctor.

If you forget to take Lisinopril Unifarm
Do not take a double dose to make up for the missed dose. Take the next dose at the usual time or consult your doctor.

If you stop taking Lisinopril Unifarm
The duration of treatment and dosage of the medicine is determined by your doctor. Discontinuation occurs after consultation with your doctor or pharmacist.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everyone gets them. You may experience the following symptoms unrelated to your primary illness:

Common (with a frequency> 1/100 to <1/10) - a sharp decrease in blood pressure (hypotension), incl. decreasing blood pressure when straightened, causing dizziness, fainting or fainting; headache and dizziness, cough, vomiting and diarrhea, impaired kidney function.
Uncommon (with a frequency> 1/1000 to <1/100) - elevated urea, creatinine (indicators of kidney function), liver enzymes and potassium in the blood; palpitations; pain behind the sternum (angina), heart attack; Raynaud's disease - Poor dewage of the toes and legs as a result of which they become stiff and pale; sleep disturbances, vertigo, decreased sex drive; depression; numbness and tingling of the hands and feet; changes in taste; nasal obstruction and cold-like symptoms; nausea, abdominal pain, indigestion; rash, itching;
Rare (with a frequency> 1 / 10,000 to <1 / 1,000) - elevated bilirubin (liver function indicator); low blood sodium which may cause tiredness and confusion, muscle twitching, seizures or coma; decreased values ​​of hemoglobin and hematocrit; confusion, dry mouth, acute renal failure, elevated urea levels in the blood; rashes, hair loss, psoriasis, gynecomastia (male breast enlargement).
Very rare (with frequency <1 / 10,000), including single cases) - decreased leucocyte and platelet counts; single cases of severe reduction in white blood cells, which increases the likelihood of infection; single cases of severe decrease in the number of blood cells, which may lead to weakness, bruising or increased likelihood of infection; reducing the number of red blood cells, which may lead to pallor or yellowing of the skin; weakness or shortness of breath; lymph node enlargement; autoimmune diseases; upper respiratory tract infections, rarely accompanied by bronchospasm, difficulty in breathing, pharyngeal pain; allergic inflammation of the lungs; a syndrome starting with congestive jaundice (yellowing of the skin and whites of the eyes caused by problems with the liver or blood), which may progress to severe fatal damage to the liver; hepatitis; inflammation of the pancreas, which causes severe pain in the abdomen and back; volvulus; constipation; intestinal angioedema (swelling of the small intestinal mucosa), loss of appetite; change of taste; decreased urine output to urine (oliguria and anuria); sweating abundantly; pemphigus; a severe skin-blistering condition; erythema multiforme (skin reaction accompanied by rashes); Stevens-Johnson syndrome (a severe disease associated with blistering of the skin, mouth, eyes and genitals); muscle spasms; decreased blood sugar levels. Skin and subcutaneous tissue disorders may be associated with fever, changes in nail sensitivity to light and exacerbation of Raynaud's disease. Not known - syncope (temporary loss of consciousness), depression.
How to Store Lisinopril Unipharm
Store in a dry place protected from light at temperatures below 25 ° C. Keep out of the reach and sight of children.
Do not use Lisinopril Unifarm after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
Do not use Lisinopril Unipharm if you notice any changes in the appearance of the tablets described in your package leaflet.
Do not dispose of medicines in the sewer or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.

6. Package Contents and Additional Information

What does Lisinopril Unipharm contain

The active ingredient is lisinopril dihydrate, e. of lisinopril 5 mg, 10 mg, 20 mg.
The other ingredients are:
5 mg tablets - mannitol, microcrystalline cellulose, corn starch, hypromellose, magnesium stearate; silicon dioxide, colloidal anhydrous.
10 mg tablets - mannitol, microcrystalline cellulose, corn starch, hypromellose, magnesium stearate; colloidal anhydrous silica; yellow iron oxide dye E172. 20 mg tablets - mannitol, microcrystalline cellulose, corn starch, hypromellose, magnesium stearate; colloidal anhydrous silica; colorants: yellow iron oxide E172 and red iron oxide E172.

What Lysinopril Unipharm looks like and contents of the pack

5 mg tablets - round, flat, white tablets with facets and scored on one side and 7 mm in diameter.
10 mg tablets - round, flat, pale yellow, scored and scored on one side and 7 mm in diameter.
20 mg tablets - round, biconvex, pale pink, scored and scored on one side and 8 mm in diameter.
10 tablets in a blister of clear, transparent PVC / aluminum foil; 3 blister cards (30 tablets) in a cardboard box together with a leaflet.

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