PENTILIN 100 mg. 5 ml. 5 ampoules

Active substance: pentoxifyline
Excipients: disodium edetate. sodium chloride, sodium dihydrogen phosphate dihydrate, disodium phosphate dihydrate, water for injections.

1. What is Pentilin and what is it used?
Ingredients:
5 ml of solution for injection (1 ampoule) contains 100 mg pentoxifyline.
Package:
Cardboard box with 5 vials of 5 ml solution for injection (100 mg / 5ml).

What is Pentilin?
Pentoxufyline acts on blood viscosity by reducing sticking her cell kompyunenti and spontaneous increase deforiiruemostta of erythrocytes. Thus, it improves blood flow in small blood vessels, especially the microcirculation and supply of tissues with oxygen.
What is Pentilin?
It is used for advanced disorders of the peripheral arterial circulation (macro- and microcirculation) caused by atherosclerosis, diabetes, vascular spasm (claudicatio intermittens, diabetic microangiopathy and macro- syndrome, Reynaud).

2. Before you use Pentilin
Tell your doctor if you have any chronic diseases, metabolic disorders, if you are allergic or if you take other medicines.
Who should not take Pentilin?
You should not take Pentilin:
if you are hypersensitive to rentoxufyline to the excipients of the medicinal product;
if you are hypersensitive to xanthine derivatives such as theophylline. caffeine, choline theophyllinate, aminophylline or theobromine;
if you have suffered acute myocardial infarction;
If you suffer from heavy bleeding or retinal hemorrhage;
if you have a disease associated with an increased risk of bleeding.
Special precautions and warnings
Before starting treatment with Pentilin tell your doctor if you are being treated for arteriosclerosis, high blood pressure, heart failure, diabetes, liver or kidney disorder, if you are on dialysis, or if you have very low or unstable blood pressure.
In advanced atherosclerosis rentoxifyline should not be injected into the affected artery.
Pentilin should be prescribed with caution in patients with heart failure because blood nalngane may suddenly decline (hypotension).
Caution should be used in patients with diabetes because high intravenous doses rentoxifuline can enhance the action of insulin or oral hypoglycemic agents.
Caution is required in patients with severe hepatic or renal impairment.
The dosage should be reduced in patients with low or unstable blood pressure because it can occur hypotension and angina.
In patients with other diseases and conditions, accompanied by bleeding (post-surgery, peptic ulcer) should be monitored prothrombin time (INR), hematocrit and hemoglobin.
Safety in patients below 18 years of age has not been established, so they should not take this medicine.

Pregnancy and lactation
Consult your doctor or pharmacist before taking any medicine.
The effect of Pentilin the fetus has not been studied, so he is appointed during pregnancy only if the doctor considers it vital. Pentilin and its metabolites pass into breast milk. The doctor will assess whether it can be used during breastfeeding or if breast-feeding should be discontinued.
Effects on ability to drive and use machines
No influence on the ability to drive or operate machinery.
What other medicines can interact with Pentilin?
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, even those without a prescription.
Coadministration of rentoxifyline and drugs for lowering high blood pressure (antihypertensives) reinforce their action, so their dose should be adjusted. Patients taking rentoxifyline simultaneously with drugs to prevent bleeding or those preventing platelet aggregation (anticoagulants or antiplatelet drugs) may increase the risk of bleeding. Therefore requires more frequent monitoring of prothrombin time (INR).
High intravenous doses rentoxifyline can enhance the action of insulin or oral hypoglycemic agents, so their dose should be adjusted. Serum concentrations of rentoxifyline significantly increased by concomitant administration of cimetidine. We have to pay attention to the signs of overdose rentoxifyline patients. Other H2-receptor antagonists (famotidine, nizatidine and ranitidine) have less influence on the metabolism of rentoxifyline. Co-administration of rentoxifyline and theophylline may result in increased serum levels of theophylline. For this reason, serum theophylline levels must be monitored and the dosage of theophylline can be reduced if necessary.
Concomitant administration of ketorolac rentoxifyline and can result in prolonged prothrombin time and increase the risk of bleeding. The risk of bleeding may also be increased by concomitant administration of repentoxifyline and meloxicam. Co-administration of these medicinal products is not recommended.
Ciprofloxacin reduces metabolism in the liver rentoxifyline. Co-administration of ciprofloxacin and rentoxifiline can lead to increased serum concentrations of rentoxifyline. If concomitant treatment with ciprofloxacin rentoxifyline and can not be avoided, dose rentoxifyline should be reduced by half.

3. How to use Pentilin?
Dosage and method of administration
The exact dosage and duration of treatment should be determined by the physician.
To establish the sensitivity of the patient to rentoxifyline, at the beginning it should be administered 50 mg pentoxifyline (half of one ampoule) diluted with 10 ml of saline (0.9% solution of NaSl).
Intra-arterial administration of rentoxifyline is recommended only in exceptional cases and only in patients with severely endangered limbs where other treatments have failed.
Treatment with injections: 1 vial (100 mg) daily injected slowly (about 5 minutes) to a patient lying on his back or intravenously or intraarterially.
Dosage in infusion therapy:
intra-arterial infusion
Initial dose of 100 mg in 100 ml fiz.r Dr.
Maintenance dose of 100 mg to 400 mg in 100 ml. fiz.r Dr.
Total daily dozirovka- 1200 mg.
Duration of infuziyata- 10 to 30 minutes.

Intravenous infusion:
Initial dose of 100 mg in 250 ml fiz.r Dr.
Maintenance dose of 30 mg to 50 mg / hour
Total daily dozirovka- 800- 1200 mg.
Infuziyata- length of 90 to 180 minutes.

Itravenozna continuous infusion:
Maintenance dose 0.6 mg / kg / hour
Total daily dozirovka- 1200 mg.
Duration of infuziyata- 24 hours

The clinical condition improved parenteral treatment is replaced with oral therapy Pentilin tablets.
Dosage in renal failure:
When creatinine clearance below 10 ml / min (0,16 ml / s), dose decrease to 50 to 70 percent of normal.
If you have the impression that the effect of the drug is too strong or too weak, you should consult your doctor or pharmacist.
If you take more than you should Rntilin
Overdose can occur following symptoms: flushing
drowsiness, fall in blood pressure, loss of consciousness, nausea, vomiting, fever, restlessness, seizures.
If you think you have received a higher dose of the drug than it should have to consult your doctor immediately.

4. Possible side effects
Like all medicines, Pentilin can also have side effects.
May appear facial flushing, headache, dizziness, insomnia, tremors, chest pain and increased heart rate.
It is also possible hypersensitivity reactions (itching, flushing, urticaria, angioedema, shock).
Very rarely can occur hypotension, agitation, nausea, vomiting, diarrhea, cholestasis, increase the activity of liver enzymes, hypoglycemia, thrombocytopenia, leukopenia, prolonged prothrombin time (or increase the INR) or bleeding in the retina.
The majority of side effects are dose-dependent. If the dose of Rentilin reduced, they weaken or even disappear. In rare cases be discontinued.
If you notice any side effects, even those not listed in this leaflet, please tell your doctor or pharmacist.


5. Storing Pentilin

Storage Conditions
Do not store above 25 ° C
Keep out of reach of children.
Expiry date:
The medicinal product should not be used after the expiry date stated on the packaging.