PRESTARIUM-KO 10 mg. / 10 mg. 30 tablets

WHAT PRESTARIUM-KO AND WHAT IT IS USED?
Prestarium co-prescribed to treat high blood pressure (hypertension) and / or treatment of stable coronary artery disease (a condition where the blood supply to the heart is reduced or blocked). Patients taking before perindopril and amlodipine from separate tablets can instead receive one tablet PRESTARIUM-KO, which contains both ingredients.
PRESTARIUM-KO is a combination of two active ingredients, perindopril and amlodipine.
Perindopril is an inhibitor of ACE. Amlodipine is a calcium antigonist (which belongs to a class of medicines called dihydropyridines). Together, they cause extension and relaxation of the blood vessels so that the blood flows more easily through them and facilitate your heart in maintaining a good blood flow.

BEFORE YOU TAKE PRESTARIUM-KO
Do not take:
- If you are allergic to perindopril or any other ACE inhibitor, or to amlodipine or other dihydropyridines or any of the other ingredients of PRESTARIUM-KO
- If you are breastfeeding
- In the last 6 months of pregnancy
- If stem experienced symptoms such as wheezing, swelling of the face or tongue, intense itching or severe skin rashes with previous ACE inhibitor treatment or if you or a member of your family has had these symptoms in any other circumstances
- If you are in a state of cardiogenic shock (when the heart can not supply enough blood to the body), aortic stenosis (narrowing of the main blood vessel leaving the heart) or unstable angina (chest pain that can occur at rest)
- If you have severe hypotension (very low blood pressure)
- If you have heart failure after acute myocardial infarction during the first 28 days.

Take special care with PRESTARIUM-KO
If you have any of the following, please report this to your doctor before taking PRESTARIUM-KO
- Hypertrophic cardiomyopathy (heart muscle disease) or renal artery stenosis (narrowing of the artery that supplies blood to the kidneys)
- Any other heart problems
- Liver problems
- Kidney problems or are on dialysis
- Kidney problems or are on dialysis
- Collagen vascular disease (disease of the connective tissue) such as systemic lupus erythematosus or scleroderma
- diabetes
- If you are on a diet with limited content of salt or use salt substitutes that contain potassium (a well-balanced level of potassium in the blood is important)
- If you think you are pregnant or might become pregnant. PRESTARIUM-KO is not recommended in early pregnancy and may cause serious harm to your baby after 3 months of pregnancy

When taking PRESTARIUM-KO, you should also tell your doctor or medical staff:
- If you are going to get general anesthesia and / or major surgery
- If you have recently suffered from diarrhea or vomiting
- If you have to be subject to (a) of LDL apheresis (atstranyavane cholesterol from your blood by a machine)
- If you desensitization treatment to reduce the effects of an allergy to bee stings or wasp.

PRESTARIUM-KO is not recommended for use in children and adolescents.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines
You should avoid intake of PRESTARIUM-KO with:
- lithium
- estramustine
- Potassium-sparing diuretics, potassium supplements or potassium containing salt substitutes.

Treatment with PRESTARIUM-KO can be affected by other medicines. Be sure to tell your doctor if you are taking / receiving any of the following medicines as you may need special attention
-Other Medicines for high blood pressure, including diuretics
- NSAIDs for pain relief or high dose aspirin,
- Medicines to treat diabetes
- Drugs to treat mental disorders, such as e. depression, anxiety, schizophrenia, etc.
- Immunosuppressive agents used to treat autoimmune diseases or after transplant surgery
- Allopurinol (for gout)
- Procainamide (to treat irregular heartbeat)
- Vasodilators incl. nitrates (products that widen blood vessels)
-heparin (medicines for blood thinning)
- Ephedrine, adrenaline, or noradrenaline (medicines used to treat low blood pressure, shock or asthma)
- Baclofen or dantrolene (infusion) both used to treat muscular rigidity in diseases such as multiple sclerosis, dantrolene be used for the treatment of malignant hyperthermia during anesthesia (symptoms including very high body temperature, and muscular rigidity)
- Certain antibiotics, such as. rifampicin
- Antiepileptic agents, such as eg. carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone,
- Itraconazole, ketoconazole (medicines used to treat fungal infections)
- Alpha-blockers used to treat enlarged prostate, such as. prazosin, alfuzosin, doxazosin, tamsulosin, terazosin
- amifostine
- corticosteroids
- Gold salts, especially with intravenous

Pregnancy and lactation
You should tell your doctor if you think you are pregnant or might become pregnant. Usually your doctor will advise you to take another medicine instead PRESTARIUM-KO, as it is not recommended in early pregnancy and may cause serious harm to your baby if used after 3 months of pregnancy. Appropriate antihypertensive drug must usually replace PRESTARIUM-KO before nabremennostta.
Your doctor will normally advise you to stop taking PRESTARIUM-KO before the start of pregnancy.
If you become pregnant during treatment with PRESTARIUM-KO, please inform and immediately go to the appointment with your doctor.

The use of this medicine is not recommended during lactation.

DRIVE AND USE MACHINES
PRESTARIUM-KO does not affect the state of wakefulness, but you could feel dizziness or weakness due to low blood pressure, which could affect your ability to drive or operate machinery.

HOW TO TAKE?
Always take the medicine exactly as your told your doctor. If you're not sure, ask your doctor or pharmacist.
Swallow your tablets with a glass of water, preferably at the same time each day, in the morning before eating. Your doctor will decide which dose is right for you. The usual dose is usually one tablet per day.

PRESTARIUM-KO is usually prescribed to patients already taking perindopril and amlodipine from separate tablets.

POSSIBLE SIDE EFFECTS
Like all medicines, PRESTARIUM-CO can cause side effects, although not everybody gets them.
If any of these side effects, stop taking the drug immediately and tell your doctor immediately:
- Swelling of the face, lips, mouth, tongue or throat, difficulty breathing
- Severe dizziness or fainting
- Unusually fast or irregular heartbeat.

Other side effects are:
Common side effects
headache, dizziness, vertigo, numbness in the limbs, drowsiness, visual disturbances, tinnitus, palpitations, flushing, loss of balance due to low blood pressure kashlishta, shortness of breath, nausea, vomiting, abdominal pain, altered taste, dyspepsia or difficulty vgaltaneto, diarrhea, constipation, allergic reactions, muscle cramps, fatigue, edema.

Uncommon side effects
rapid mood swings, sleep disturbances, tremor, syncope, loss of pain sensation, rhinitis, changes in bowel habits, hair loss, red or discolored skin patches, back pain, muscle or joint pain, chest pain, frequent urination especially at night, malaise, bronchospasm, dry mouth, angioedema symptoms such as wheezing, swelling of the face or tongue, kidney changes, impotence, increased potlivost, enlarged breasts in men, weight gain or weight loss

Very rare side effects
confusion, cardiovascular disorders, eosinophilic pneumonia, erythema multiforme, blood disorders, pancreas, stomach or liver, peripheral neuropathy, abnormally increased muscle tone, vasculitis, swollen gums, high blood sugar

Looks like and contents of pack
PRESTARIUM-KO 10 mg / 5mg tablets are white, round tablets engraved with 10/10 on one side and a sign on the other side