Ravel SR 1.5 mg. 30 tablets

What is Ravel SR and what it is used
Ravel SR is used to reduce high blood pressure (hypertension). It is a prolonged-release tablet containing indapamide as active ingredient. Indapamide is a diuretic.
Most diuretics increase the amount of urine excreted by the kidneys. However, indapamide is different from other diuretics, as it only causes a slight increase in the amount of urine.
2. Before you take Ravel SR
Do not take Ravel SR:
• If you are allergic (hypersensitive) to indapamide or any other ingredients of Ravel SR or other similar medicines (called sulfonamides).
• If you have severe kidney disease.
• If you have severe liver disease, or if you suffer from a condition called hepatic encephalopathy (degenerative brain disease).
• If you have low potassium levels in the blood.
Take special care with Ravel SR
Please tell your doctor:
• If you have liver problems;
• If you have diabetes;
• If you suffer from gout;
• if you have impaired kidney function;
• if you have any heart rhythm problems;
• If you need a study to see how the parathyroid gland you.
Tell your doctor if you have had photosensitivity reactions (to light).
If you think any of these things may apply to you, or if you have any questions or concerns about taking this medicine, talk to your doctor or pharmacist.
Your doctor may order laboratory tests to check for low sodium or potassium levels or high calcium levels.
Important information for athletes
Athletes should be aware that this medicine contains an active substance which may give a positive reaction in doping tests.
Taking other medicines
Concomitant use of Ravel SR and certain other medicines may increase the effect of one or another drug and may cause side effects.
Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
You should not take Ravel SR simultaneously with lithium (used to treat depression) due to the risk of increased levels of lithium in blood.
Tell your doctor if you are taking any of these medicines as may be required special attention:
• Medicines used for heart rhythm problems (eg. Quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, ibutilide, dofetilide, digitalis)
• Medicines used to treat mental illnesses such as depression, anxiety, schizophrenia (eg. Tricyclic antidepressants, antipsychotic drugs, neuroleptics)
• bepridil (used to treat angina (angina pectoris), a disease that causes chest pain)
• Cisapride, diphemanil (used for the treatment of gastrointestinal problems)
• sparfloxacin, moxifloxacin (antibiotics used to treat infections),
• Halofantrine (an antiparasitic medicament for the treatment of certain types of malaria),
• Pentamidine (used to treat certain types of pneumonia),
• mizolastine (used to treat allergic reactions such as hay fever),
• NSAIDs for pain relief (eg., Ibuprofen), or high doses of acetylsalicylic acid,
• Angiotensin converting enzyme (ACE) inhibitors (used to treat high blood pressure and cardiac insufficiency)
• Oral corticosteroids used for treating a variety of disorders including severe asthma and rheumatoid arthritis,
• Stimulant laxatives,
• Baclofen (to treat muscle stiffness occurring in diseases such as multiple sclerosis)
• Potassium-sparing diuretics (amiloride, spironolactone, triamterene)
• Metformin (for treating diabetes),
• iodinated contrast agents (used for studies involving the use of X-rays),
• Calcium tablets or other calcium supplements,
• cyclosporin, tacrolimus or other medicines that suppress the immune system after organ transplantation, to treat autoimmune diseases, or severe rheumatic and dermatological diseases
• tetracosactide (for the treatment of Crohn's disease).
Taking Ravel SR with food and drink
Food and drink have no influence on the effect of Ravel SR.
Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine. This medicine is not recommended during pregnancy. When pregnancy is planned or confirmed, it should switch to an alternative treatment as quickly as possible.
Please tell your doctor if you are pregnant or want to become pregnant.
The active substance is excreted in human milk. If you are taking this medication, breastfeeding is not recommended.
Driving and using machines
This medicine may cause side effects as a result of lowering blood pressure, such as dizziness or tiredness (see. Pt. 4). These side effects occur most often in the beginning of treatment or after a dose increase. If this happens to you, you should refrain from driving and other activities requiring alertness.
Important information about some of the ingredients of Ravel SR
Ravel SR contains lactose. If your doctor told you that you have an intolerance to some sugars, contact him before taking this medicine.

3. How to take Ravel SR
Always take Ravel SR exactly as you have been told by your doctor. You should check with your doctor or pharmacist if you are not sure. Ravel dose is one tablet daily. Take this medicine every day at the same time, preferably in the morning; Swallow the tablets whole with some liquid. The tablets can be taken with or without food. Do not crush or chew.
Treatment of high blood pressure usually continues throughout life.
If you take more Ravel SR Avelox
If you take too many tablets, contact your doctor or pharmacist. Very high doses of Ravel SR can cause nausea, vomiting, decreased blood pressure, cramps, dizziness, drowsiness, confusion and changes in the amount of urine produced by the kidney.
If you forget to take Ravel SR
If you forget to take a dose of your medicine, take the next dose at the usual time.
Do not take a double dose to make up for a missed tablet.
If you stop taking Ravel SR
As the treatment for high blood pressure usually continues throughout life, talk to
your doctor before you stop taking this medicine.
If you have further questions about using this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, Ravel SR can cause side effects, although not everybody gets them. The frequency of side effects listed below are determined according to the following categories:
• Very often, it occurs in more than 1 in 10 patients
• Often, it manifests itself in 1 to 10 in 100 patients
• Uncommon: occurs at 1 to 10 of 1000 patients
• Rare manifests itself in 1 to 10 in 10,000 patients
• Very rare: it manifests itself in less than 1 in 10,000 patients
• Not known: frequency can not be predicted from the available data.
These may include:
• Common:
> Low levels of potassium in the blood, which can cause muscle weakness.
• Uncommon:
> Vomiting, allergic reactions, mainly skin, such as skin rash, purpura (red spots on the skin) in subjects with a predisposition to allergic and asthmatic attacks.
• Rare:
> Feeling of tiredness, dizziness, headache, tingling (paraesthesia); Gastrointestinal disorders (such as nausea, constipation), dry mouth; Increased risk of dehydration in the elderly and in patients suffering from heart failure.
• Very rare:
> Cardiac rhythm disorders, low blood pressure; Kidney disease; including failure of the kidneys to function properly; Pancreatitis (inflammation of the pancreas, causing pain in the upper abdomen), abnormal liver function. In cases of liver failure can occur hepatic encephalopathy (degenerative disease of the brain);
Changes in blood cells, such as thrombocytopenia (decrease in the number of platelets which causes easy bruising with minor trauma, and also bleeding from the nose), leukopenia (decreased white blood cells, which can cause fever of unknown origin, sore throat or other flu-like symptoms - if this occurs, contact your doctor) and anemia (reduction in red blood cells); Angioedema and / or urticaria, severe skin manifestations. Angioedema is characterized by swelling of the skin of the legs or of the face, swollen lips or tongue, swelling of the throat or the airways, resulting in shortness of breath or difficulty in swallowing. If this happens, contact your doctor immediately. If you suffer from systemic lupus erythematosus (a type of connective tissue disease), it could be worse. It has also been reported cases of hypersensitivity reactions (change in skin appearance) after exposure to the sun or artificial UVA rays.
• You may experience some changes in your blood and your doctor may refer you to do blood tests to check your condition.
> The following changes in laboratory values may occur: low potassium in the blood, which may cause muscle weakness,
> Low level of sodium in the blood, which can lead to dehydration and low blood pressure,
> Increased uric acid - a condition that can cause or worsen gout (painful joints especially on the feet);
> Increasing the level of blood glucose in diabetics;
> Enhancement of calcium in the blood.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
5. How to store Ravel SR
• Keep out of reach of children.
• Do not use Ravel SR after the expiry date stated on the packaging. The expiry date refers to the last day of that month.
• Do not store above 25 ° C.
• Store in the original package to protect from moisture.