Timolol Kolir. 0.25% 10ml

ACTION
Timolol belongs to a group of medicines called beta-blockers. Applied in the form of eye drops lowers intraocular pressure without changing the size of the pupil and visual acuity. Intraocular pressure lowering effect is particularly pronounced at elevated intraocular pressure, but is also observed at normal pressure. Onset of action is approximately 20 minutes following instillation into the eye. The maximum effect is reached after 1-2 hours and lasts for about 24 hours. It is assumed that timolol reduces the production of fluid in the eye chamber and improves its outflow.
 
INDICATIONS
Timolol is prescribed for lowering intraocular pressure in conditions such as: ocular hypertension, glaucoma, chronic open the drainage angle some instances secondary glaucoma.
 
CONTRAINDICATIONS
You should not use Timolol if you have allergy to any component of the formulation; bronchial asthma, severe chronic obstructive pulmonary disease, heart disease, in which there is a slow heart rate and conduction disturbances (bradycardia, atrioventricular block), overt cardiac failure.
 
SPECIAL WARNINGS AND PRECAUTIONS
VnimaniePoradi that Timolol can penetrate the conjunctiva and fall into the systemic circulation, the product must be used with caution in patients prone to lower blood sugar in diabetic patients receiving insulin or other oral preparations glucose lowering in patients with thyrotoxicosis (overactive thyroid gland), muscle weakness, lung disease, heart failure. You must inform your doctor if you suffer from any of the diseases or have ever had any other health problems.
Sometimes, during prolonged application, the effect of the preparation on intraocular pressure to lose weight. In worsening of symptoms or onset of new, you should tell your doctor. Timolol eye drops contains benzalkonium chloride as an excipient, which is deposited in soft contact lenses. You should not take Timolol while wearing such lenses. They must be removed before use of the preparation and not reinserted earlier than 15 minutes after that. For sure if you wear contact lenses, consult with your doctor before you start using timolol.
Where have used so far antiglaucoma preparation should be replaced with Timolol, this should be done only by a physician. Use in pregnancy and karmeneAko you are pregnant or breast-feeding, tell your doctor. It will assess whether you can use Timolol.
Not recommended for pregnant women, except after a very rigorous assessment of the benefits and risks of implementation. Timolol is excreted in breast milk and may cause side effects on the infant.
 Use in children has been established safety and efficacy of administration of timolol in detsa.Vliyanie on ability to drive and use driver influence.
 
DRUG INTERACTIONS AND OTHER
Tell your doctor about all medications and eye drops to use, even for those you bought without a prescription. This is especially important when using drugs to lower blood pressure or to treat heart disease.
When concomitant administration of timolol with calcium antagonists (verapamil, nifedipine), drugs that reduce the level of catecholamines (reserpine) and other drugs known as beta-blockers administered orally may occur lowering blood pressure or slow heart rhythm. In ophthalmology when combining timolol with drops containing epinephrine may occur pupillary dilation (that is, directed observation).
Preparation for external use? Eye drops - the preparation is placed into the conjunctival sac. Instillation is carried out in hygienic conditions. Avoid contact of the dropper to your eye or surrounding structures. Keep the close properly after each use. The dosage and duration of treatment is determined by your doctor. If your doctor advises otherwise, it is recommended to start treatment with 1 drop of 0.25% solution 2 times a day. If the effect is insufficient applies a 0,5% solution - 2 times daily 1 drop. Upon satisfactory stabilization level of intraocular pressure treatment in most cases you can continue with the application of 1 drop daily. Intraocular pressure should be monitored regularly 3-4 weeks after initiation of treatment and periodically thereafter.
In patients who did not achieve the required effect, the doctor may recommend a combination of timolol with other drugs, miotics, adrenaline, carbonic anhydrase inhibitors.
 
 
 Overdose
Upon topical application of the composition at the recommended doses are not observed toxic effects. In case of accidental ingestion of large quantities of the preparation, may be observed nausea, vomiting, cardiovascular disorders. You must immediately contact your doctor.
 
SIDE REAKTsIIPreparatat generally well tolerated. Rarely signs of eye irritation such as burning and stinging, redness of the eye, dry eyes, itching, foreign body in the eye, double vision and other visual disturbances.
Sometimes Topical beta-blocker can cause the same side effects that occur with systemic administration (eg. In the mouth), as it can penetrate into the systemic circulation. Can be observed cardiovascular events (slow heart rate, arrhythmia, drop in blood pressure, atrioventricular block); bronchospasm, respiratory failure; cough, shortness of breath, masking the symptoms of low blood sugar in patients with diabetes, allergic reactions (hives, itching, swelling of the face and / or eyelids); common events (headache, weakness and fatigue, chest pain), psychological reactions and neurological manifestations (confusion, depression, muscle weakness, tingling), gastrointestinal events (nausea, diarrhea) .For event listed or not listed in the leaflet let your doctor.
Store protected from light at a temperature below 30 ° C! Keep out of reach of children!
SHELF GODNOSTTri (3) years.
Do not use after the expiry date stated on the packaging.
 The solution can be used within 30 days after opening the vial.