TRIBESTAN R 60 tablets

On the antiquity Tribulus terrestris L is used for the treatment of urinary infections, as a diuretic and for colic. Tribestan e in clinical practice from the 80s of the twentieth century in many countries of Europe, Asia and the USA. It turns obshtotonizirashto action and stimulating some of the functions of the reproductive system. It is used in infertility and impotence, to mitigate the climacteric events in women in metabolic disorders and for building muscle mass. The product improves the erections, as happens under the influence of modern phosphodiesterase inhibitors, but also enhances libido. The low rate of excretion of unchanged protodioscin compared to the dose shown to be subjected to extensive biotransformation.

The results prove that Tribestan influences the serum level of hormones from pituitary-gonadal axis, without changing significantly the concentration of adrenal hormones and adrenocorticotropic hormone (ACTH). In women increased follicle stimulating hormone (FSH) and estradiol, and in men - luteinising hormone (LH) and testosterone (3). Tribestan turns and hypolipemic action, in men with dyslipoproteinemia significantly reduced total cholesterol and cholesterol in low density lipoproteins (LDL-Ch), without affecting reliably serum levels of triglycerides and cholesterol in high density lipoprotein cholesterol (HDL-Ch) . On rabbit corpus cavernosum has been found to provide protodiostsinat proerektilno action. Admitted to an increased release of nitric oxide from the endothelium and nitrergic nerve endings (6). Tribulus terrestris increases nitric oxide synthase (NOS) in the hypothalamus of rats (14).

When entering testosterone in certain doses of men increases sperm, strengthens the libido, improving erections and reduces total cholesterol (19). Such changes occur and under the influence of Tribestan exercising testosteronopodobno action. Under his influence increased secretion of LH from the pituitary gland that stimulates the secretion of testosterone by the testes, which obyasnnyava positive effect on the libido and physical exercise (22). Not in all cases increases serum testosterone may think that Tribestan influence by the androgen receptor, selectively binding to it and so it mimics the action of testosterone, including the hypothalamus, and is not excluded in other departments brain. (2) In rats it was found that the prolonged effects of Tribulus terrestris increases the expression of the androgen receptor (14). Predominant protodioscine metabolised to dehydroepiandrosterone (DHEA) (7). Same and its sulphate ester (DHEAS) act on immunity, cell membrane integrity and overall tone (5). Suggests that DHEA counteract aging and extract Tribulus terrestris L., containing phyto-DHEA may be the drug of choice in the elderly (9). DHEA and DHEAS are important links in the conversion of cholesterol into hormones in the normal course of steroidosinteza. Lowering cholesterol levels showed that Tribestan interfere with metabolism, which explains hypolipemic action. Significance have other active saponins constituting the The extract of Tribulus terrestris L., which modulate the action of protodioscin in the body.
 
APPLICATION OF TRIBESTAN

Male infertility. Infertility is a condition in which the unsuccessful attempts to become pregnant within 12 months. In 40% of cases the fault is in the man. The statistics do not cover unmarried, those who are unaware that they are infertile or unwilling to investigate and treat. In the study in, 71 men with infertility due to chronic prostatitis, chronic epididymitis, after resection for varicoceles and idiopathic oligoastenozoospermiya Tribestan was administered for 2 months. The number and proportion of motile sperm well in idiopathic oligoastenoteratozoospermiya and infertility caused by varicocele (4). In a double-blind, multicenter study 39 men with idiopathic oligoastenoteratozoospermiya were treated with Tribestan for 12 weeks. Pregnancies are marked after a period of four months at 22% of the wives of the patients (17). Applying Tribestan reduces locally emitted immunoglobulins, it can also be applied to infertility, conditioned by the presence of antibodies to sperm and / or seminal plasma (20).

Impotence (erectile dysfunction). In the world 152 million men suffer from erectile dysfunction. (11, 19). It is assumed that in 2025 the number will be 350 million. Product of Tribulis terrestris L was administered at 3 times 1 tablet daily for two weeks in 11 patients - four men reduced to no libido and 7 patients with impotence. Of these, 50% have improved libido and 57.1% have improved erections and prolong (Nasution, 1993, personal communication). In another study, 45 men (30 and 15 without diabetes mellitus) with erectile dysfunction and decreased libido were treated with extract of Tribulus terrestris. Improving libido has been found in 20 (67%) of male non-diabetic and in 8 (53%) of those with diabetes. Enhancement of libido and frequency of intercourse, a total of 28 (62%) of men with erectile dysfunction, in a further 10 days after the beginning of treatment (7,8). Increased serum levels of DHEAS and presumably affect sexual function by converting protodioscin in DHEAS. An advantage of Tribstan is that unlike phosphodiesterase inhibitors improves libido.

Climacteric syndrome and postcastration. It was found that Tribestan sledmenopauzalnite relieves symptoms - neurovegetative psychiatric manifestations and symptoms in the cardiovascular system. Hot flushes decreased libido increases and improved psycho-emotional state. Avoid the risk of developing cancer of the genitals and mammary glands, which enter into consideration in the use of hormonal products. The authors note that the shift from curative maintenance dose should be gradual and for a longer period of time. (24)

Hyperlipoproteinaemia (dyslipoproteinaemia). The serum total cholesterol level decreased significantly in men under the influence of Tribestan (2). In a single-center, open-label, prospective study on 49 patients with dyslipidemia been studied Tribestan for 90 days at a daily dose of 1500 mg. A statistically significant decrease in the values of LDL-Sh and total cholesterol. Triglycerides and HDL-Ch is not statistically significant. During the study were not observed abnormal laboratory values that have clinical relevance. The authors note that in therapy TribestanR for 90 days in patients with dyslipoproteinaemia noted good tolerability and safety of the medicinal product