TUSARI 75 mg. 30 tablets

What is Tusari and what is it used?
Tusari contains acetylsalicylic acid in low doses belongs to a group of medicines called anti-platelet agents. Platelets are small cells in the blood which cause blood clotting, and are associated with thrombosis. When in the artery to form a blood clot, it stops blood flow and interrupt the supply of oxygen. When this occurs in the heart, it can cause a heart attack or angina pectoris, and in the brain can cause strokes.
Tusari be taken for reducing the risk of blood clot formation and thus to prevent:
heart attack;
stroke;
cardiovascular events in patients suffering from stable or unstable angina (presenting with chest pain).
Tusari also be used to prevent the formation of blood clots after certain types of surgical operations on the heart which are performed to extend or clogged coronary arteries.
2. What you need to know before taking Tusari?
Do not take Tusari:
if you are allergic to aspirin or any of the other ingredients of this medicine (listed in section 6);
if you are allergic to salicylates or other nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs are commonly used for arthritis or rheumatism and pain;
if you had an asthma attack or swelling in some parts of the body such as the face, lips, throat or tongue (angioedema) after taking salicylates or NSAIDs;
if you currently have or have ever had ulcers in the stomach or intestines or other bleeding such as stroke;
if you have ever had a problem with blood clotting;
if you have severe liver or kidney problems;
if you are in the last 3 months of pregnancy, unless your doctor has told you to take it, in which case the daily dose should not exceed 100 mg (see section "Pregnancy, breast-feeding and fertility");
if taking a medicine, called methotrexate (for example, cancer or rheumatoid arthritis), at doses higher than 15 mg per week.
Warnings and Precautions
Talk to your doctor, pharmacist or nurse before taking Tusari:
if you have kidney problems, liver or heart;
if you have or have ever had problems with your stomach or intestines;
if you have high blood pressure;
if you suffer from asthma, hay fever, nasal polyps or other chronic respiratory diseases - acetylsalicylic acid can cause an asthma attack;
if you have ever had gout;
if you have heavy menstrual periods.
You should seek immediate medical attention if your symptoms worsen or if you get serious or unexpected adverse reactions such as unusual symptoms of bleeding, serious skin reactions or other sign of serious allergy (see section "Possible side effects").
Tell your doctor if you plan to have surgery (even a mild one such as tooth extraction). Since acetylsalicylic acid thins the blood, there may be an increased risk of bleeding.
You must be careful not to become dehydrated (you can feel the thirst and dry mouth), since the use of acetylsalicylic acid also can worsen kidney function.
This product is not suitable as an analgesic or antipyretic agent.
If any of the above applies to you or you are not sure, ask your doctor or pharmacist.
Children and adolescents
Aspirin can cause Reye's syndrome when given to children. Reye's syndrome is a very rare disease that affects the brain and liver, and can be life-threatening. Therefore Tusari should not be used in children under the age of 16 years unless under a doctor's prescription.
Other medicines and Tusari
Tell your doctor or pharmacist if you are taking, you have recently taken or might take any other medicines.
The effect of treatment can be influenced if acetylsalicylic acid is taken simultaneously with certain other medicines for:
diluting the blood / prevention of clot formation (eg. warfarin, heparin, clopidogrel);
prevent rejection after organ transplantation (eg. cyclosporin, tacrolimus);
treatment of high blood pressure (e. diuretics or ACE inhibitors);
regulating heart rate (eg. digoxin);
treatment of bipolar disorder (eg. lithium);
treatment of pain and inflammation (eg. NSAIDs such as ibuprofen or steroids);
gout (eg., probenecid);
treatment of epilepsy (e. valproate, phenytoin);
treatment of cancer or rheumatoid arthritis (eg. methotrexate);
diabetes (e. glibenclamide);
treating depression (selective inhibitors of serotonin reuptake (SSRI) such as paroxetine or sertraline);
drugs used as hormone replacement therapy when the adrenal glands or the thyroid has been removed or damaged, or to treat inflammation, including rheumatic diseases, and inflammatory bowel disease (e. corticosteroids);
treatment of altered levels of blood lipids (nicotinic acid).
Tusari alcohol
Consuming alcohol may possibly increase the risk of gastrointestinal bleeding and prolong bleeding time.
Pregnancy, lactation and fertility
If you are pregnant or breast-feeding, you think you may be pregnant or planning to become pregnant, ask your doctor or pharmacist before taking this medicine.
Pregnant women should not take aspirin during pregnancy, except as prescribed by a doctor.
You should not take Tusari if you are in the last 3 months of pregnancy, unless your doctor prescribes it in which case the daily dose should not exceed 100 mg (see section "Do not take Tusari"). Regular intake or high doses of this medicine during late pregnancy can cause serious complications in the mother or baby.
Nursing mothers should not take aspirin unless as prescribed by a doctor.
Driving and using machines
Tusari can cause dizziness. You should not drive or operate machinery until you know whether this medication affects your ability to perform these activities.
3. How to take Tusari?
Always take this medicine exactly as described in this leaflet or as you have been told your doctor or pharmacist. If you're not sure, ask your doctor or pharmacist
Adults
Prevention of heart attack:
The recommended dose is 75-150 mg once daily.
Prevention of stroke:
The recommended dose is 75-300 mg once daily.
Prevention of cardiovascular problems in patients who suffer from stable or unstable angina (presenting with chest pain):
The recommended dose is 75-150 mg once daily.
Preventing blood clots after certain types of heart surgery:
The recommended dose is 75-150 mg once daily.
Elderly
The dosage is the same as for adults. In general, acetylsalicylic acid should be used with caution in elderly patients as they are more prone to adverse events. Treatment should be periodically reviewed.
Use in children and adolescents
Acetylsalicylic acid should not be used in children and adolescents under 16 years except as prescribed by a doctor (see section "Children and adolescents").

Method of administration
For oral administration.
The tablets should be swallowed whole with sufficient fluid (1/2 cup water). The tablets have a gastro-resistant coating that prevents irritation of the stomach and therefore should not be crushed, broken or chewed. The tablets should not be taken with antacids (medicines used to relieve heartburn or indigestion), as they will destroy the enteric coating of tablets and can irritate the stomach.
As enteric coating delays absorption, Tusari not recommended in patients with acute myocardial infarction (to treat heart attack). In case of emergency, however, the tablets may be crushed or chewed in order to accelerate the absorption of acetylsalicylic acid.
If you take more than the amount Tusari
If you (or someone else) accidentally take too many tablets, tell your doctor immediately or immediately contact the nearest emergency department. Show the doctor the rest of the drug or the empty package.
Symptoms of overdose may include tinnitus, hearing problems, headaches, dizziness, confusion, nausea, vomiting and abdominal pain. A large overdose may lead to more rapid than normal breathing (hyperventilation), fever, excessive sweating, restlessness, seizures, hallucinations, low blood sugar, coma and shock.
If you forget to take Tusari
If you miss a dose, wait until it comes time for your next dose, then continue taking your medicine as usual.
Do not take a double dose to make up for a missed tablet.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
If you stop taking Tusari
If you stop taking Tusari, contact your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
If you notice any of the following serious side effects, stop taking Tusari and immediately contact a doctor:
- Sudden difficulty in breathing, swelling of the lips, face or body, rash, fainting or difficulties in swallowing (severe allergic reaction);
- Skin redness blistering or peeling which can be associated with fever and arthralgia. This may be erythema multiforme, Stevens-Johnson syndrome or Lyell;
- Unusual bleeding such as coughing up blood, vomiting blood, blood in urine or black stools.
Common side effects (may affect up to 1 in 10 people):
indigestion;
increased bleeding tendency.
Uncommon side effects (may affect up to 1 in 100 people):
hives;
nasal irritation;
difficulty breathing.
Rare side effects (may affect up to 1 in 1000 people):
heavy bleeding in the stomach or intestines, brain hemorrhage, altered blood counts;
nausea and vomiting;
spasms of the lower respiratory tract, asthma attack;
inflammation of blood vessels;
Bruising with purple spots (bleeding);
severe skin reactions such as rash, known as erythema multiforme, and its life-threatening forms - Stevens-Johnson syndrome and Lyell;
Hypersensitivity reactions such as swelling example of the lips, face or body, or shock;
unusually heavy or prolonged periods.
Adverse reactions known (from the available data can not be estimated frequency):
ringing in the ears (tinnitus) or weakening the power of hearing;
headache;
vertigo (dizziness);
ulcers of the stomach or small intestine and perforation;
prolonged bleeding time;
impairment of renal function;
damage to liver function;
High levels of uric acid in the blood.
Adverse event reporting
If you get any side effects, contact your doctor or pharmacist. This includes any possible effects not listed in this leaflet. You can also report side effects directly via the Drug Agency.
By reporting side effects, you can do your bit for getting more information on the safety of this medicine.
5. How to store Tusari?
Keep out of reach of children.
Bottle for tablets: Keep the bottle tightly closed in order to protect from moisture.
Blister: Store in the original blister in order to protect from moisture.
Do not store above 30 ° C.
Do not use this medicine after the expiry date stated on the carton or bottle for tablets / blister after "EXP". The expiry date refers to the last day of that month.
Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer use. These measures will help to protect the environment.
6. Contents of the pack and other information
What Tusari?
The active substance is acetylsalicylic acid. Each gastro-resistant tablet contains 75 mg or 100 mg acetylsalicylic acid.
Other ingredients are:
75 mg strengths: microcrystalline cellulose, maize starch, colloidal anhydrous silica, talc, gelatin, magnesium oxide heavy (tablet core); copolymer type A and methacrylic acid - ethyl acrylate, polysorbate 80, titanium dioxide, red iron oxide (E172), black iron oxide (E 172), sodium laurilsulfag, colloidal anhydrous silica, sodium bicarbonate, triethyl citrate, talc (tablet coat) .
100 mg dose unit, microcrystalline cellulose, maize starch, colloidal anhydrous silica, talc, gelatin, magnesium oxide heavy (tablet core); copolymer type A and methacrylic acid -etilakrilat, polysorbate 80, titanium dioxide, sodium lauryl sulfate, colloidal anhydrous silica, sodium bicarbonate, triethyl citrate, talc (tablet coat).
Tusari looks like and contents of the pack?
Tusari 75 mg gastro-resistant tablets are pink, biconvex, unmarked tablets in the shape of a heart.
Tusari 100 mg gastro-resistant tablets are white, biconvex, unmarked tablets in the shape of a heart.
Pack sizes:
Tusari is available in blister packages of 28 or 50 gastro-resistant tablets and bottles containing 30, 50, 60, 90 or 100 gastro-resistant tablets.
Not all pack sizes may be marketed.

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