ZIBOR 3500 IU. 2 injections

What is Zibor 3500 III anti-Xa / 0.2 ml and what is it used for?
Zibor 3500 anti-Xa / 0.2 ml (bemiparin sodium) belongs to a group of medicines called anticoagulants (anticoagulants) that help protect the blood from clotting in the blood vessels.
This medicine is always prescribed by a doctor and used to protect blood from clotting, in the veins of the lower limbs and / or the lungs that may occur if you are undergoing orthopedic surgery (hip, knee joint or other surgery). It is also used to prevent the formation of blood clots in the tubes of a hemodialysis apparatus.
2. Before using Zibor 3500 IU anti-Xa / 0.2 ml
Please read the instructions in section 3 "How to use Zibro 3500 IU anti-Xa / 0.2 ml"
Do not use Zibor 3500 IU anti-Xa / 0.2 ml
• if you have had an allergic reaction after another medicine containing imipramine sodium, heparin or substances of swine origin;
• if you suffer from heparin-induced thrombocytopenia (HIT) - a condition where the blood platelet count decreases (blood cells responsible for blood clotting) and in laboratory tests they cling to each other with Zibor 3500 anti-Xa / 0.2 ml. Your doctor will tell you if you suffer from this disease;
• if you suffer from a condition that leads to a tendency to excessive bleeding;
• if you have severe liver and / or pancreatic disease;
• if you have disseminated intravascular coagulation (DIC, systemic intravascular coagulation) which is explained by heparin-induced decrease in platelet count;
• if you suffer from a condition called endocarditis (inflammation of the heart and heart valves). Your doctor will tell you if you suffer from it;
• if you have a high risk of bleeding (eg active stomach ulcer, stroke, brain tumors or if you have a cerebral haemorrhage);
• if you have a trauma or are planning to operate the brain, spine, eyes and / or ears.

Take special care with Zibor 3500 IU anti-Xa / 0.2 ml
• if you have liver or kidney disease;
• if you have high blood pressure and / or have difficulty controlling it;
• if you have had a stomach ulcer;
• if you suffer from thrombocytopenia - a condition where the number of blood platelets decreases, resulting in an easy onset of bruising and bleeding. Your doctor will tell you if you suffer from this disease;
• if you have stones in the kidneys and / or the urinary tract;
• if you have a disease with increased bleeding tendency. Ask your doctor if you are not sure;
• if you have eye disease caused by blood vessels;
• if anesthesia is to be applied to the spine (epidural or spinal anesthesia prior to surgery) and / or if a lumbar puncture (lumbar spine puncture for laboratory tests) is to be performed;
• if you have diabetes or if you are aware of high levels of potassium in the blood;

Special warnings
Children
The use of Zibor 3500 anti-Xa / 0.2 ml in children is not recommended

Elderly
The same dose should be used as for other age groups.

Renal and hepatic impairment
Dosing of the dose of imiparin in this patient group can not be recommended due to lack of data.

Pregnancy
There is insufficient experience to recommend Zibor 3500 anti-Xa / 0.2 ml in pregnant women. Before starting treatment with Zibor 3500 anti-Xa / 0.2 ml, you should tell your doctor if you are pregnant or suspect that you are pregnant. Ask your doctor or pharmacist before taking any medicines!

Breastfeeding
Before starting treatment with Zibor 3500 anti-Xa / 0.2 ml, you should tell your doctor if you are breast-feeding. Ask your doctor or pharmacist before taking any medicines!

Driving and using machines
Zibor 3500 IU anti-Xa / 0.2 ml does not affect the ability to drive or use machines.

Taking other medicines
Tell your doctor if you take other anticonvulsants such as vitamin K antagonists (warfarin); non-steroidal anti-inflammatory drugs such as ibuprofen; platelet inhibitors such as acetylsalicylic acid (aspirin), ticlopidine, clopidogrel and others; medicines that protect against potassium loss; heart medicines such as nitroglycerin and medicines that increase blood volume as dextran.
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Medical research that may be needed:
• In some patients, it may be necessary to determine the number of platelets in the blood. Your doctor will decide if this is necessary.
• If you suffer from certain diseases (diabetes, kidney disease) or if you are taking potassium-sparing prophylaxis, your doctor may check the potassium levels in your
How to use Zibor 3500 IU anti-Xa / 0.2 ml?
Always use Zibro 3500 IU anti-Xa / 0.2 ml exactly as your doctor has told you. If you are not sure, ask your doctor or pharmacist.
Zibor 3500 anti-Xa / 0.2 ml should not be injected into the muscle and should not be mixed with other injections.
To protect the blood from clotting in the veins during orthopedic surgery
Zibor 3500 anti-Xa / 0.2 ml is generally administered by a doctor or nurse by subcutaneous injection (that is, it is injected under the skin, usually in the skin of the abdomen or the upper thigh). Before or after the operation, one dose of the product (the contents of one syringe) is administered. Subsequent days are administered at one dose (the contents of one syringe) each day. Your doctor will tell you how long your treatment will last.

Prophylaxis of blood clotting during hemodialysis
When used in hemodialysis, Zibor 3500 anti-Xa / 0.2 ml is usually administered by injecting one bolus dose (the contents of one syringe) into the arterial end of the hemodialysis apparatus.

If you use more than the required dose of Zipon 3500 IU anti-Xa / 0.2 ml
This can lead to bleeding. If this happens, tell your doctor immediately or go to the emergency room at the nearest hospital by taking this leaflet with you.

If you forget to use Zibor 3500 III anti-Xa / 0.2 ml
Do not take a double dose to make up for a missed dose and consult as soon as possible with your doctor. He will advise you how to proceed in this case.

4. Possible side effects
Like all medicines, Zibor can cause side effects, although not everyone gets them.
Stop using Zorb and tell your doctor or nurse immediately (or go to the emergency room immediately at the nearest hospital) if you notice any of the following side effects:

Common (affects to 1 in 10 patients):
- abnormal or unexpected bleeding, e.g. blood in urine and / or stool.

Rare (affects 1 to 1,000 patients)
- a very low blood platelet count (Type II thrombocytopenia).
- Dark, painful spots on the skin at the injection site (skin necrosis).
- Hematoma in the spinal cord following spinal or lumbar anesthesia. These hematomas can cause to varying degrees neurological damage, including prolonged or permanent paralysis.
- Serious allergic reactions (increased body temperature, fever, difficulty in breathing, swelling of the vaginal javelin, vertigo, sweating, nettle rash / urticaria, itchy skin, low blood pressure, hot flushes, redness, fainting, bronchospasm, swelling of the glottis) .

Very rare (affects less than 1 in 10,000 patients):
Bone breakage (osteoporosis) due to prolonged use of heparins.
- increase in potassium levels reflected in blood tests.

Other side effects: Very common (affects more than 1 user in 10)
- bruising, itching and pain at the injection site.

Common (affects 1 to 10 patients)
- a slight and transient increase in certain enzymes (transaminases) reflected in blood tests.

Uncommon (affects to one in 100 patients):
- mild allergic skin reactions: skin rash, nettle rash / urticaria.
- a slight and temporary decrease in the number of blood platelets (Type I thrombocytopenia) reflected in blood tests.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
How to store Zibor 3500 IU anti-Xa / 0.2 ml?
Keep out of the reach of children!
Store below 30 ° C. Do not freeze!
Pre-filled syringe with a single dose. Unused quantity to be destroyed! Do not use if the protective packaging is torn or damaged. Only clear, colorless or slightly yellowish solutions without visible particles should be used.
Do not use Zibro 3500 IU anti-Xa / 0.2 ml after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
Ziphon should be used immediately after the first opening.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of your unnecessary medicines. These measures will help to protect the environment.

6. Additional information
What Zibar contains 3500 IU anti-Xa / 0.2 ml?
- The active substance is: bimiparin sodium (bemiparin sodium). One 0.2 ml syringe contains 3500 IU anti-Xa imiparin sodium.
- The other ingredients are: water for injections.

What Zibor 3500 III Anti-Xa / 0.2 ml looks like and what does the package contain?
Zibor 3500 anti-Xa / 0.2 ml is in packs of 2, 10, 30 and 100 pre-filled syringes with 0.2 ml solution for injection.

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