ZOFEN 7.5 mg. 28 tablets

What is Zofen 7,5 mg, 30 mg and what it is used
Zofen 7,5 mg, 30 mg contains zofenopril calcium, which belongs to the group of blood pressure lowering drugs, m. Called. Angiotensin-converting enzyme (ACE).
Zofen 7,5 mg, 30 mg was used to treat high blood pressure (hypertension). It is also used to treat heart attack (acute myocardial infarction) in patients with or without signs and symptoms of heart failure and who have not received treatment that helps break down blood clots (thrombolytic therapy).

2. Before you take Zofen 7,5 mg, 30 mg of
Do not take Zofen 7,5 mg, 30 mg if:
you are allergic (hypersensitive) to any of the ingredients (see. Section 6 "What Zofen 7,5 mg, 30 mg");
you have had an allergic reaction to any other ACE inhibitor such as captopril or enalapril;
you had a strong swelling and itching of the face, nose and throat (angioneurotic edema) in previously treated with an ACE inhibitor or suffer from hereditary / idiopathic angioneurotic edema (rapid swelling of the skin, tissues, digestive tract and other organs);
suffer from severe liver problems;
have narrowing of the renal arteries;
You are pregnant or breastfeeding;
you are a woman of childbearing potential, unless using effective contraception.
Take special care with Zofen 7,5 mg, 30 mg of
Please consult your doctor before taking Zofen 7,5 mg, 30 mg, if:
have high blood pressure and problems with the liver or kidneys;
have high blood pressure due to kidney problem or narrowing of the artery supplying blood to the kidney (renovascular hypertension);
you have recently had a kidney transplant;
you are undergoing dialysis;
you undergo LDL-apheresis (a procedure similar to hemodialysis, blood purifier of harmful cholesterol);
You have in their blood increased levels of the hormone aldosterone (primary aldosteronism);
in a narrowing of the aortic valve (aortic stenosis) or thickening of the walls of the heart (hypertrophic cardiomyopathy);
suffer or have suffered from psoriasis (a skin disease characterized by scaly pink patches);
if you undergo desensitisation treatment (injections in allergic diseases) to insect stings.
Your blood pressure can be reduced significantly with the use of Zofen 7,5 mg, 30 mg, especially after the first dose (this is typical if you take diuretics, if you are dehydrated or if you are subjected to a diet, limiting salt intake). In such cases, contact your doctor immediately and lie back.
If you have an operation, tell your anesthetist before being anesthetized acceptance Zofen 7,5 mg, 30 mg. This will help him / her to control blood pressure and heart function during the procedure.

If you have suffered a heart attack (acute myocardial infarction) and:
have low blood pressure (<100 mmHg) or are in circulatory shock (due to heart problems) - Zofen 7,5 mg, 30 mg are not recommended;
you are aged over 75 years - Zofen 7,5 mg, 30 mg should be used with special care.
Zofen 7,5 mg, 30 mg are not recommended in children and adolescents.

Taking other medicines
Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

In particular, tell your doctor if you are taking:
drugs that increase the level of potassium in the blood (eg potassium-sparing diuretics or potassium supplements);
lithium (used for the treatment of behavioral disorders);
anesthetics;
narcotics (such as morphine);
antipsychotic agents (used in the treatment of schizophrenia and other diseases);
other medicines to lower blood pressure (including diuretics, α-blockers and β-blockers);
antacids including cimetidine (used for heartburn or stomach ulcers);
ciclosporin (used after organ transplants) or other immunosuppressive agents (drugs that suppress the body's defense system);
allopurinol (used in the treatment of gout);
insulin or oral antidiabetics;
cytostatics (used in the treatment of cancer or a disease affecting the body's defense system);
corticosteroids (powerful anti-inflammatory drugs);
procainamide (used to treat irregular heartbeat);
nonsteroidal anti-inflammatory drugs (NSAIDs, such as aspirin or ibuprofen);
sympathomimetic drugs (drugs affecting the nervous system, including medicines to treat asthma and hay fever).
Taking Zofen 7,5 mg, 30 mg with food and drink
Zofen 7,5 mg, 30 mg may be taken before or after a meal, but the best tablet should be taken with water. Alcohol increases the hypotensive (blood pressure lowering) effect of Zofen 7,5 mg, 30 mg; ask your doctor for further advice when taking alcohol during treatment with Zofen 7,5 mg, 30 mg.

Pregnancy and lactation
Do not take Zofen 7,5 mg, 30 mg, if you are pregnant, planning a pregnancy or breast-feeding. The drug can harm the fetus if you are pregnant or pass or milk if you are breastfeeding.
Ask your doctor for advice before taking any medicine.

Driving and using machines
This medicine can cause drowsiness or fatigue. In such cases it is advisable to drive or operate machinery.

Important information about some of the ingredients of Zofen 7,5 mg, 30 mg of
This medicinal product contains lactose - if you know that you have an intolerance to some sugars, contact your doctor before taking this medicine.

3. How to take Zofen 7,5 mg, 30 mg of
Always take Zofen 7,5 mg, 30 mg exactly as your doctor tells you. If you're not sure, ask your doctor.
Zofen 7,5 mg, 30 mg may be taken before or after food. Best tablet should be taken with water.
It is not recommended that this drug be taken by children and adolescents.

Treatment of high blood pressure (hypertension)
The normal initial dose Zofen is 15 mg once daily. Your doctor will gradually adjust the dose (usually four weeks) to achieve the appropriate dose for you. Prolonged antihypertensive effect is usually achieved with the 30 mg once daily Zofen. The maximum dose is 60 mg per day, taken all at once or in two divided doses.
If you are dehydrated, with salt deficiency or are taking diuretics (water tablets), it is necessary to start treatment with 7,5 mg, 30 mg of Zofen.

Liver or kidney problems
If you suffer from mild to moderate hepatic impairment or moderate to severe renal impairment, your doctor will start with a half dose of Zofen. If you are on hemodialysis, at the beginning of your treatment is necessary a quarter of the dose.

Heart attack (acute myocardial infarction)
Zofen therapy should be initiated within 24 hours after onset of symptoms. The dose you will receive is as follows:
7,5 mg twice daily for the first and second day of treatment;
15 mg twice daily during the third and fourth day of treatment;
after the fifth day, the dose can be increased to 30 mg twice daily;
according to blood pressure, your doctor will determine the maximum dose;
If symptoms of heart failure persist, treatment can last six weeks or more.
If you take more dose Zofen 7,5 mg, 30 mg of
If you accidentally take too many tablets, contact your doctor immediately or go to the nearest emergency medical care (take with you, if possible, any remaining tablets, packaging or leaflet).
The most frequent symptoms and signs of overdose are low blood pressure with fainting (hypotension), slow heart rate (bradycardia), changes in some blood parameters (electrolytes) and impaired renal function.

If you forget to take Zofen 7,5 mg, 30 mg of
If you miss a dose Zofen 7,5 mg, 30 mg, take the next one as soon as possible after you have established. If it's been a long time (eg several hours) and your next dose is rather skip the missed dose and take the next normal dose at the usual time as prescribed. Do not take a double dose to make up the missed dose.

If you stop taking Zofen 7,5 mg, 30 mg of
Always consult your doctor before discontinuing use of Zofen 7,5 mg, 30 mg of whether taking it for high blood pressure or after a heart attack.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, Zofen 7,5 mg, 30 mg can cause side effects, although not everybody gets them.
Most adverse reactions associated with the use of ACE inhibitors are reversible and disappear after cessation of therapy.

Common side effects (affecting less than 1 in every 10 treated):
fatigue (tiredness);
nausea and / or vomiting;
dizziness;
headache;
cough.
Uncommon side effects (affecting less than 1 in every 100 treated):
general weakness;
muscle cramps;
skin rash.
Rare side effects (affecting less than 1 in every 1,000):
swelling and itching, especially on the face, mouth and throat, with possible difficulty in breathing.
Besides the adverse reactions reported when taking Zofen 7,5 mg, 30 mg may occur following side effects typical of ACE inhibitors:
sharp reduction in blood pressure at the beginning of treatment or when increasing the dose by dizziness, blurred vision, fainting (syncope);
fast or irregular heartbeat, palpitations and chest pain (heart attack or angina pectoris);
reduced consciousness, sudden dizziness, sudden disruption of vision or weakness and / or loss of the sense of touch in one half of the body (transient ischemic attack or stroke);
peripheral edema (water retention in the extremities), drop in blood pressure on standing, chest pain, muscle pain and / or cramps;
decreased renal function, change in amount of urine separated during the day, presence of protein in the urine (proteinuria), impotence;
abdominal pain, diarrhea, constipation, dry mouth;
allergic reactions such as skin rash, hives (urticaria), itching, flaking, redness, soreness and blistering of the skin (toxic epidermal necrolysis), exacerbation of psoriasis (a skin disease characterized by the formation of scaly pink patches) hair loss (alopecia);
increased sweating and flushing;
mood swings, depression, sleep disturbances, altered sensitivity of the skin burning, numbness or tingling (paraesthesia), impaired balance, confusion, ringing in the ears (tinnitus), taste disturbances, blurred vision;
difficulty breathing, narrowing of the airways in the lung (bronchospasm), sinusitis, runny or stuffy nose (rhinitis), inflammation of the tongue (glossitis), bronchitis;
yellowing of the skin (jaundice), inflammation of the liver or pancreas (hepatitis, pancreatitis), bowel obstruction (ileus);
changes in blood tests, for example. change in the number of red blood cells, white blood cells or platelets, or reduction in the number of all blood cells (pancytopenia). Tell your doctor if you notice that you bruise in minor injuries or no reason you have a sore throat and fever;
increased blood levels of liver enzymes (transaminases) and bilirubin, increased blood urea and creatinine;
anemia due to destruction of red blood cells (hemolytic anemia), which may occur if suffer from glucose-6-phosphate dehydrogenase deficiency.
If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.

5. Storing Zofen 7,5 mg, 30 mg of
Keep out of reach of children!
This medicinal product does not require any special storage conditions.
Do not use Zofen 7,5 mg, 30 mg after the expiry date ("EXP") shown on the carton and blister. Always store the tablets in the original package.
Medicines should not be disposed of in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Further information
What Zofen 7,5 mg, 30 mg of
The active substance is zofenopril calcium (zofenopril calcium): 7,5 mg, 30 mg.
Other ingredients are: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, colloidal anhydrous silica, hypromellose, titanium dioxide (E171).