AGAPURIN 100 mg. 60 tablets

Active substance:
Pentoxifylline 100 mg in 1 coated tablet.
Excipients:
Core:
Lactose monohydrate, corn starch, talc, magnesium stearate, colloidal silicon dioxide.
Shell:
Sodium carboxymethylcellulose, granulated sugar, powdered sugar, gum arabic, talcum, colloidal silicon dioxide, methyl parahydroxybenzoate, titanium dioxide (E 171).
Formulation and packaging

Coated tablets.

Content of one package:
60 coated tablets.

Vasodilator, rheological agent

Action:

The active substance belongs to the group of xanthine derivatives; It improves blood flow in the blood vessels and increases the flexibility of red blood cells. It inhibits platelet aggregation and decreases blood viscosity. As a result, it improves blood circulation and blood supply to tissues with compromised blood supply.
Indications:
Agapurin is intended for use in adults with disorders of the peripheral circulation due to reduced peripheral vascular blood flow in tissue disorders due to insufficient blood supply (eg. Ulcers of the lower leg) in ischemic attack (cerebral atherosclerosis, post-stroke conditions), poor circulation of the eye and inner ear.

Contraindications:

Agapurin should not be used in known hypersensitivity to the active substance and / or any of the excipients in severe haemorrhage, brain and retinal hemorrhage, severe bleeding disorders. In acute myocardial infarction, severe hypotension or arrhythmias, the preparation should be used only when absolutely necessary.
The medicinal product should be avoided during pregnancy and lactation.
It is necessary to consult your doctor in case of occurrence of any of the above conditions during treatment with the drug.
Special warnings and precautions drank use

In patients with hypotension or heart disease can lower blood pressure induced by Agapurin and in rare cases to occur stenocardiac problems (chest pain). Therefore, it is necessary to monitor blood pressure during treatment. Administration of high doses of the drug in patients with diabetes treated with insulin or oral antidiabetic agents, may lead to a pronounced hypoglycemia (low blood sugar), and it is therefore necessary to adjust the dose in these patients during treatment with Agapurin .

Drug interactions:

Agapurin effect of other concomitantly administered medicines may affect each other. Therefore, your doctor should be informed about all the medicines you are currently taking, or begin to take, whether prescribed or freely marketable. Before taking any freely marketable product, it is necessary to consult with your doctor. Agapurin may enhance the effects of medicinal products used for the treatment of hypotension and potentiate the reduction of blood pressure when used concomitantly with other drugs. Agapurin potentiate the action of anticoagulants.

Dosage and administration:

The dosage is always determined by the doctor. The customary dose in the beginning of treatment 2 tablets 3 times a day. In a significant drop in blood pressure, as well as more prolonged treatment, the dose was reduced to 1 tablet 3 times daily.
Method of administration
The tablets should be taken with sufficient liquid and must not be chewed or crushed.

Undesirable effects:

Medicinal prlodukt generally well tolerated, but may experience gastrointestinal symptoms (nausea, vomiting, weight and stomach pain), dizziness, flushing (at about 4-6% of patients). In rare cases may occur itching and skin rashes. Heart rhythm disorders, symptoms of angina (chest pain) and decrease in blood pressure can occur in isolated cases, particularly after taking high doses. In rare cases, it may be observed bleeding (eg. Skin, mucosa, or gastrointestinal tract), especially in patients taking anticoagulants (drugs to prevent blood clotting) simultaneously Agapurin. In case of occurrence of adverse events or other unusual reactions you should consult with your doctor about the further use of the product.

Storage:

Do not store above 25 ° C. Protect from moisture and light.

Expiry date:

5 years.

Caution:

Keep out of reach of children!
Do not use after the expiry date which is stated on the packaging.