AGAPURIN SR 600 mg. 20 tablets

Pentoxifylline 600 mg 1 prolonged-release tablet.

Excipients:
Core:
Eudragit RS PO, RL PO eudrazhit, polyvidone K25, talc, magnesium stearat.Obvivka Magnesium Stearate, 12.5% eudrazhit E, talc, magnesium stearate, macrogol 6000.

Formulation and packaging
Prolonged-release tablets


Pharmacotherapeutic group
Vasodilator, rheological agent


Action
The active substance belongs to the group of xanthine derivatives; It improves blood flow in the blood vessels by increasing the flexibility of red blood cells. Inhibits platelet aggregation and reduces blood viscosity, thus improving blood circulation and blood flow to the tissues with poor blood circulation.


Evidence
Agapurin is intended for use in adults with disorders of the peripheral circulation due to reduced peripheral vascular blood flow in tissue disorders due to impaired blood supply (eg. Ulcers of the lower leg) in ischemic attack (cerebral atherosclerosis, post-stroke conditions), impaired blood supply of the eye and inner ear.


Contraindications
Agapurin should not be used in known hypersensitivity to the active substance and / or any of the excipients in severe haemorrhage, brain and retinal hemorrhage, severe bleeding disorders. In acute myocardial infarction, severe hypotension or arrhythmias, the preparation should be used only when absolutely neobhodimost.Prilozhenieto of Agapurin not recommended during pregnancy and karmene.Neobhodimo is to consult your doctor in case of occurrence of any of the above conditions during treatment with preparata.Spetsialni warnings and precautions upotrebaPo during therapy with the drug should be monitored blood pressure, since patients with hypotension and unstable blood circulation blood pressure can be lowered and, in rare cases, occur stenocardiac problems (chest pain behind the breastbone). The administration of high doses of the drug can result in very low blood sugar in diabetic patients treated with insulin or oral antidiabetics. Therefore, there is a need to adjust dosages in these patients during treatment with Agapurin.


Interactions
Agapurin effect of other concomitantly administered medicines may affect each other. Therefore, your doctor should be informed about all the medicines you are currently taking, or begin to take, whether prescribed or freely marketable. Before taking any freely marketable product, it is necessary to consult with your doctor. Agapurin may enhance the effects of medicinal products used for the treatment of hypotension and potentiate the reduction of blood pressure during concomitant use with other medicinal products. Agapurin potentiate the action of anticoagulants.


Dosage and method of administration
The dosage is always determined by the doctor. The customary dose in the beginning of the treatment is 1 tablet 2 times daily.


Method of administration
The tablets should be taken with or after food, with a little liquid and must not be chewed or crushed.


Overdose

In case of overdose or accidental ingestion of the medicinal product by the child should seek lekar.Nezhelani reaktsiiLekarstveniyat medicinal product is generally well tolerated but may experience gastrointestinal symptoms (nausea, vomiting, weight and stomach pain), dizziness, flushing (at about 4-6% of patients). In rare cases may occur itching and redness of the skin. Heart rhythm disorders, symptoms of angina (chest pain behind the breastbone) and decreases in blood pressure can occur in isolated cases, particularly after taking high doses. Very rarely, can be observed bleeding (eg. Skin, mucosa, or gastrointestinal tract), especially in patients taking anticoagulants simultaneously Agapurin. In case of occurrence of adverse events or other unusual reactions you should consult with your doctor about the further use of the preparation.


Storage
Do not store above 25 ° C. Protect from moisture and light.

Expiry date
4 years.


Caution
Keep out of reach of children!
Do not use after the expiry date which is stated on the packaging.