ALDIZEM 60 mg. 30 tablets

What is Aldizem and what it is used
The main ingredient in the tablets Aldizem is diltiazem. Aldizem belongs to a group of medicines called "calcium channel blockers". It inhibits the entry of calcium ions into cells of the heart and blood vessels. As a result, the blood vessels expand, reducing the overload of the heart, increased blood flow to it, and improves its supply with oxygen. Diltiazem reduces elevated blood pressure and heart rate / pulse delay /.
Aldizem is indicated for the treatment of:
angina, vasospastic angina (caused by a spasm of blood vessels); angina after myocardial infarction;
treatment of arterial hypertension / high blood pressure /.

2. What you need to know before taking Aldizem
Do not take Aldizem:
if you are allergic (hypersensitive) to diltiazem or any of the other ingredients of this medicine (listed in section 6);
if you are allergic (hypersensitive) to other calcium channel blockers;
If you suffer from low blood pressure;
if you suffer from heart failure;
if you spent acute myocardial infarction complicated by heart failure;
if you have a slow pulse / especially below 55 bpm / or have other violations in the conduct of excitatory impulses in the heart;
if you are pregnant or breast-feeding;
diltiazem should not be co-administered with dantrolene administered as an infusion (a medicament for muscle spasm);
if you are already taking medicine containing ivabradine for the treatment of certain heart diseases.
Warnings and Precautions
Talk to your doctor or pharmacist before taking Aldizem:
if you suffer from impaired function of the left ventricle;
if you have heart rhythm problems (eg. delayed conduction) need special attention, because this drug can suppress conducting impulses;
if you suffer from impaired liver function the daily dose should not exceed 90 mg, and require regular monitoring;
if you have impaired kidney function.
It is possible to experience hypotension (less than normal blood pressure), treatment with diltiazem. Your blood pressure needs to be monitored, especially when starting treatment with diltiazem when determining the correct dose for you.
If you experience persistent dermatological reactions, treatment with diltiazem should be discontinued. If you are having surgery with general anesthesia, you should tell the anesthetist that you are being treated with diltiazem.
If you are an elderly patient, your doctor may reduce your dose.
Children and adolescents
The safety and efficacy of diltiazem in children is well established.
Other medicines and Aldizem
Tell your doctor or pharmacist if you are taking, you have recently taken other or might take any other medicines.

It is necessary to take into account interactions with the following drugs:
any medication for high blood pressure such as beta-blockers (eg. atenolol), diuretics (eg. furosemide or hydrochlorothiazide) or ACE inhibitors (eg., captopril or enalapril);
antiarrhythmic drugs to treat irregular or fast heart rhythm (eg. digoxin or amiodarone);
cyclosporine, administered to prevent rejection after transplantation or for the treatment of other disorders of the immune system;
theophylline for the treatment of respiratory difficulties such. asthma;
certain drugs known as protease inhibitors for the treatment of HIV (e. atazanavir or ritonavir);
carbamazepine in the treatment of seizures or convulsions;
drugs known as H2-antagonists, for the treatment of gastric ulcer, indigestion or burning, such as. cimetidine or ranitidine;
inhalation anesthetics (e. halothane, isoflurane, enflurane, etc.);
salicylates (eg. aspirin, etc.), non-steroidal anti-inflammatory drugs (eg. indomethacin, etc.).
Diltiazem may be administered simultaneously with oral antidiabetic agents, anticoagulants / anticoagulants / drugs that reduce blood fat / lipid-lowering / dewatering / diuretics / and with nitroglycerin.

Aldizem with food, drinks and alcohol
Not recommended simultaneous reception of alcohol, due to strengthening of the vasodilating action.

Pregnancy, lactation and fertility
If you are pregnant or breast-feeding, you think you may be pregnant or planning to become pregnant, ask your doctor or pharmacist before taking this medicine.
Diltiazem should not be given during pregnancy and lactation. Before the appointment of diltiazem in women of childbearing age should exclude the possibility of pregnancy.

Driving and using machines
No evidence of a negative effect on the ability to drive and use machines. However, if you feel dizzy or sleepy, you should not drive or operate machinery.

Aldizem contains lactose. If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this product.

3. How to take Aldizem
Always take this medicine exactly as you have been told by your doctor or pharmacist. If you're not sure, ask your doctor or pharmacist.
The dose, route of administration and the duration of therapy is determined by the attending physician. The dosage is individual and can be changed depending on the condition of the patient.

ALDIZEM 60 mg prolonged release
The recommended daily adult dose is one tablet of 60 mg, three times a day, with the possibility of a dose increase to 1.5 or 2 tablets of 60 mg, three times a day.

ALDIZEM of 90 mg prolonged-release tablets
The recommended daily adult dose is one tablet of 90 mg, twice daily, with an option to increase the dose to 2 tablets of 90 mg, twice daily. The maximum daily dose is 360 mg.
It is important to take the tablets every day at the same time, preferably with a glass of water. The dose you take will depend on your condition and whether you are taking other medications.

If you take more than the amount Aldizem
Overdose of diltiazem occur bradycardia and hypotension (a slow heart rate and low blood pressure normal), heart block and cardiac decompensation. In this case, having gastric lavage with charcoal, and specific therapy.

If you forget to take Aldizem
In the event that a dose is missed, the next dose should be taken as soon as possible. If the timing of your next dose has come, then you should skip the missed dose and continue with the implementation of the drug, according to details mode.
Do not take a double dose to make up the missed dose.

If you stop taking Aldizem
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Very common side effects (may affect more than 1 in 10 people):
headache.
Common side effects (may affect up to 1 in 10 people):
dizziness, physical weakness and loss of strength, loss of appetite, nausea, discomfort in the upper part of the stomach, constipation.
They also observed swelling of the lower limbs, skin redness, faster heart rate and hypotension (low blood pressure normal), which are dose-dependent and usually transient.

Uncommon side effects (may affect up to 1 in 100 people):
somnolence, insomnia, depression, anxiety, restlessness, involuntary movements, uncontrolled speech;
slower heart rate, heart block, which can cause dizziness, syncope (fainting) and palpitations;
dry mouth, vomiting, diarrhea, indigestion, weight gain;
clinically significant increase in the level of liver enzymes and serum bilirubin;
skin problems such as increased sensitivity to light, rash and itching, sexual dysfunction in both sexes.
Rare side effects (may affect up to 1 in 1,000 people):
difficulties in vision, double vision or dry eyes;
strengthening of chest pain, blackouts and fainting, muscle pain or cramps in different places (hand, knee, leg, foot, thigh);
allergic reaction to the drug, manifested by rash, itching, blistering of the skin, mouth, eyes, genitals, skin (erythema multiforme and exfoliative dermatitis).
Other side effects that may be observed in patients who had a heart attack are: damage to the peripheral tissues, extrasystoles and worsening congestive heart failure.

Very rare side effects (may affect up to 1 in 10,000 people):
proliferation of gum, characterized by solid and painless swelling in patients over 50 years, which resolved after discontinuation of the drug. In isolated cases have been reported for breast enlargement in males.
For many calcium antagonists have been reported to cause increased urine output, frequent urination and night awakening due to urge incontinence.

By reporting side effects, you can do your bit for getting more information on the safety of this medicine.

5. How to store Aldizem
Keep out of reach of children.
This medicine does not require any special storage conditions. Do not use Aldizem after the expiry date stated on the carton after (the abbreviation used to mark the expiry date). The expiry date refers to the last day of that month.
Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer use. These measures will help to protect the environment.

6. Contents of the pack and other information
What Aldizem
The active substance is diltiazem.
Each Aldizem 60 mg of prolonged-release tablet contains 60 mg of diltiazem hydrochloride.
Each Aldizem 90 mg prolonged-release tablet contains 90 mg of diltiazem hydrochloride.
Other ingredients are: magnesium stearate; lactose monohydrate; macrogol 6000; castor oil, hydrogenated.

Aldizem looks like and contents of the pack
Aldizem 60 mg of prolonged-release tablets are white, round, convex tablets, scored on one side.
30 tablets in PVC / Al blister pack / 3 blisters of 10 tablets / placed in a cardboard box.