ANDROCUR DEPOT 300mg ampoules. 3 ml. 3 ampule

What is in Androcur Depot
The active substance is cyproterone acetate (cyproterone acetate). 1 ampoule contains 300 mg of cyproterone acetate in an oily solution.
Other ingredients: benzyl benzoate, camphor oil injections.
 
 
1. Androcur Depot What is and what it is used
Androkur hormonal products active against male hormones. It acts by suppressing the influence of male sex hormones (androgens) in target organs, e. prostate antagonizing an androgen-dependent pathologies. Androkur Depot also reduces the concentration of testosterone in the blood, which has an additional therapeutic effect. There is a tendency to a slight increase in prolactin (a hormone) with high doses of cyproterone atsetat.Po during therapy with Androkur Depot, libido and potency are reduced and testicular function is suppressed. All these changes were reversible upon discontinuation of treatment.
Androkur Depot is used for:
Suppression of libido in sexual deviations in men inoperable carcinoma prostatataAndrokur Depot is supplied in vials amber of 3 ml, glass type I.
 
2. Before taking on Androcur Depot
Do not take Androkur:
When a prescribed reduction in sexual libido deviations Androkur depot should not be taken in the presence of any of the conditions listed below. If this applies to you, tell your doctor before starting treatment.
• if you have liver disease;
• if you suffer from congenital liver dysfunction with impaired release of pigment in red blood cells called bilirubin (syndrome Dubin-Johnson or Rotor);
• if you have a history or evidence of benign or malignant liver tumors;
• if you suffer from a debilitating disease (disease causing loss of strength);
• if you have severe chronic depression;
• if you have a history or evidence of impaired circulation: in practice conditions associated with thrombosis (blood clot) in the blood vessels (thromboembolism);
• if you have severe diabetes with vascular involvement;
• If you have sickle cell anemia;
• if you suffer from hypersensitivity (allergy) to cyproterone acetate or any of the other ingredients of Androkur.
When prescribed as therapy antpandrogenna RIP inoperable prostate cancer Androkur Depot should not be taken in case of any of the conditions listed below. If this applies to you, tell your doctor before starting treatment.
• if you have liver disease;
• if you suffer from congenital liver dysfunction with impaired release of pigment in red blood cells called bilirubin (syndrome Dubin-Johnson or Rotor);
• if you have a history or evidence of benign or malignant liver tumor (only if there is metastasis of prostate cancer);
• if you suffer from a debilitating disease (disease causing loss of strength, with the exception of inoperable prostate cancer);
• if you have severe chronic depression;
• if you have a history or evidence of impaired circulation: in practice conditions associated with thrombosis (blood clot) in the blood vessels (thromboembolism) - if you have a hypersensitivity (allergy) to cyproterone acetate or any of the other ingredients of Androkur.
 
Take special care with Androcur Depot therapy:
• Regarding the indication "suppress libido in sexual deviations" decreased libido Androkur effect may be reduced under the influence of alcohol.
• Androkur should not be given before the end of puberty, since it can not be ruled out its adverse impact on growth, more unstable hormonal regulation. • During treatment should regularly examine liver function, hormonal function of the adrenal glands and the number of red blood cells.
• In some cases, high doses Androkur been reported for liver function abnormalities, some of them severe (hepatitis and liver failure, which have been fatal in some cases). Most messages are for men with prostate cancer. Liver function abnormalities are dose dependent and usually develop several months after starting treatment. Therefore, your doctor should monitor your liver function before and during treatment, especially if symptoms occur or signs of liver toxicity (eg, itching, yellowing of the skin).
• As with other sex steroids in isolated cases have been reported for benign and malignant liver changes. In very rare cases, liver tumors may lead to life-threatening internal bleeding. Therefore, the doctor should be informed about the occurrence of unusual symptoms in the upper abdomen that do not resolve spontaneously within a short time.
• If you have diabetes, tell your doctor, as this disease requires close monitoring during treatment with Androkur.
• Sometimes Androkur can lead to a feeling of breathlessness.
• Patients treated with Androkur been reported occurrence of thromboembolic events, although not established causality. Patients with a history of arterial or venous thrombosis / thromboembolism (eg deep vein thrombosis, pulmonary embolism, myocardial infarction) or cerebrovascular accident ("stroke") or advanced malignancy are at increased risk of thromboembolism.
• If you have prostate cancer, tell your doctor if you have had in the past, circulatory disorders: mainly those conditions associated with thrombosis (blood clot) the blood vessels (thromboembolism) or have sickle-cell anemia or severe diabetes with vascular changes, b.p. Under these conditions require careful consideration of the benefit / risk ratio for each individual case before prescribing Androkur.
• Like all oily solutions and Androkur Depot must be injected intramuscularly. Experience shows that the transient effects (coughing fit, respiratory distress), which rarely happens to occur during or immediately after the injection of the oil composition, can be avoided by slow injection of a solution.
 
Taking Androcur Depot along with food and drink:
Not applicable.
 
Pregnancy and lactation
Not applicable.
Driving and using machines
Androkur Depot can cause fatigue and reduced vitality and impair the ability of a concentration (eg road users, machine operators and other type of occupation that requires high concentration).
 
Taking other medicines:
The need for oral antidiabetic agents or insulin may be promenena.Molya tell your doctor or pharmacist if you are taking or have recently taken any other medicines, even those that are not prescription. This practice applies to medicines containing ketoconazole, itraconazole, clotrimazole, ritonavir, rifampicin, phenytoin, products containing St. John's wort products belonging to the group of statins (drugs to lower blood fats, eg. Cholesterol, triglycerides) risk of statin-related side effects on muscle tissue (ie. myopathy or rhabdomyolysis) may increase if certain statins are administered with high therapeutic doses of cyproterone acetate as the same pass metabolism.
 
3. How to take Androcur Depot
Dosage in the male
Injections should be administered very slowly. Androkur depot is shown only for intramuscular injection. Special care is needed to avoid intravascular injection.
• Suppression of libido in sexual deviations in men
Usually by deep intramuscular injection is placed 1 ampoule Androkur Depot every 10-14 days. If the exception proves the effect is unsatisfactory, every 10-14 days will receive 2 vials, one on the left and right of the sedalishteto.Kogato get a satisfactory result, you should try to reduce the dose gradually increasing the interval between inzhektsiite.Za to stabilize the therapeutic effect requires continuous application of Androcur Depot and possibly both psychotherapeutic lechenie.Androkur Depot should not be used continuously, possibly along with psychotherapy to achieve a stable therapeutic effect.
• inoperable prostate cancer
1 ampoule per week by the deep intramuskulno.Lechenieto should not be stopped and the dose should be reduced after improvement or remission.
If you have the impression that the effect of Androkur is too strong or too weak, talk to If you take more than the required amount Androcur Depot:
Toxicological studies with a single dose of cyproterone acetate showed that the active substance of Androkur Depot can be classified as practically non-toxic. No risk of acute intoxication after a single involuntary intake higher than the therapeutic dose.
 
If you miss Androcur Depot injection:
Revisit your doctor put you missed injection. Not require a double dose.
Effects when discontinued therapy Androkur Depot
Initial symptoms for which it was prescribed Androkur can reappear.
 
4. Possible side effects
Like all medicines and Androkur can have adverse reaktsii.Nay severe adverse reactions associated with the use of Androkur are listed in the section "Take special care with Androkur Depot therapy." Other adverse reactions reported with the use of cyproterone acetate, in which the bond to Androkur neither demonstrated nor rejected, are:
Snstemo-oragnni classes very often £ tenth Often £ 1/100 and <1/10 Not often £ 1/1.000 and <1/100 Rare £ 1/10.000 and <1/1000 Very rare <1/10.000
 
Immune system disorders Hypersensitivity Reaction
Metabolism and nutrition Increase or decrease in weight
Psychiatric disorders diminished libido, erectile dysfunction, depressive moods Anxiety (transient)
Skin and subcutaneous tissue disorders Rash
Disorders of the musculoskeletal system and connective tissue Osteoporosis
Reproductive system and breast Reversible inhibition of spermatogenesis Gynecomastia
General disorders and administration site conditions Fatigue Hot flushes Sweating
In patients who are treated with Androkur, libido and potency are reduced and testicular function is suppressed. These changes were reversible upon discontinuation of treatment.
For several weeks, Androkur Depot suppresses sperm (sperm) as a result of the anti-androgen and antigonadotropic action. Spermatogenesis is recovering gradually, a few months after stopping Depo lechenieto.Androkur can cause breast swelling (ie. Gynecomastia, sometimes combined with sensitivity to touch the nipple), usually resolves after discontinuation of use.
As with any anti-androgen treatment, continued treatment with Androkur Depot can lead to osteoporoza.Ako notice any side effects not listed in this leaflet, please tell your doctor shi pharmacist.
 
5. Storage Androcur
Keep out of reach of children.
Do not use after the expiry date stated on the packaging.