ARGOSULFAN 2% cream 400 g

Active substance: Silver sulphathiazole 20 mg / 1 g. 
Excipients: The liquid paraffin, cetostearyl alcohol, white petrolatum, sodium lauryl sulfate, glycerol, methyl hydroxybenzoate, propylhydroxybenzoate, monobasic potassium phosphate, dibasic sodium phosphate and water for injection.

Properties and action:
Argosulfan cream accelerates the healing of burns, prevents infections, relieves pain and feeling of the wound;
Argosulfan cream contains silver Sulphathiazole. Exhibit an antibacterial effect in a wide spectrum of activity on Gram (+) and Gram (-) bacteria. A slight pressor effect when used topically;
Hydrophilic carrier contains a large amount of water and ensure adequate moisture, promote wound healing and has a soothing effect;
Local applications Argosulfan cream does not cause darkening of the skin or underwear.
indications:
For the treatment of infections in all degrees of skin burns (including radiation);
Treatment of decubitus ulcers;
Treatment of chronic leg ulcers.
Contraindications:
Hypersensitivity to other sulfonamide Sulphathiazole;
Congenital deficiency of glucose-6-phosphate dehydrogenase;
Do not use in premature infants and infants under the age of two months.
Undesirable effects:
Usually Argosulfan cream is well tolerated. Possible symptoms of irritation manifested as a burning sensation at the application site;
During long-term use may occur hepatic or renal disorders;
In extremely rare cases following a Argosulfan cream can lead to damage to the hematopoietic system or edrolyuspest dermatitis, allergic reactions.
Interactions:
Derivatives of folic acid or p-aminobenzoic acid (e.g. procaine) can weaken the effect of the antibacterial agent.

Dosage and method of administration
Argosulfan cream may be used with or without a dressing.

burns
After cleaning and surgical preparation of the wound, subject to the requirements for sterility, applied a layer of 2-3 mm. Cream to cover the affected area during the period of treatment to recovery or transplantation of skin.

Ulcers and bedsores ultseriratsii chronic leg
Thin layer of cream is applied to the lesions areas 2-3 times daily. When used on infected wounds may occur escudos. In this case, before the re-application of the cream, the wound should be washed with a 0.1% aqueous solution of chlorhexidine or a 3% aqueous solution of boric acid.

Elderly
No alteration of dosage.

children
This medicinal product must not be administered to premature infants and infants under two months, since the risk of reinforcing the jaundice of the newborn. In older children do not need dosage adjustment.

Patients with renal insufficiency
Due to the lack of clinical studies, the use of drugs in patients with renal insufficiency should be done with caution. We need a control serum Silver sulphathiazole in patients with severe renal insufficiency.

Patients with hepatic impairment
Due to the lack of clinical studies, the use of drugs in patients with hepatic impairment should be done with caution.

Special warnings and special precautions for use
It is possible that the development of cross-allergies with derivatives of sulfonylurea benzotiazidi, p-aminosalicylic acid. Argosulfan cream contains methyl-and propylhydroxybenzoate, which can cause allergic reactions;
Be administered with caution to patients in shock or hard contact patients with serious burns;
During long-term administration should be monitored serum sulfonamide, especially in patients with renal or hepatic impairment because of the risk of accumulation.
Pregnancy and lactation
pregnancy
Not conducted extensive research on humans. Not recommended for use during pregnancy except in cases where therapeutic benefit outweighs the risk to the fetus.

Safety for use in pregnancy:
Category:
breastfeeding
It is not known whether topical cream Argosulfan passes into breast milk. It is not recommended to breastfeed during treatment with it.

Effects on ability to drive and use machines
Argosulfan cream does not impair psychomotor performance, has no effect on the ability to drive and use machines.

overdose
Not observed with local application.

Expiration date
two years
Shelf life after opening the bottle - 1 month.
Prior to adoption of the product to check the expiration date on the package.
Do not apply after the expiration date.

Special precautions for storage:
Do not store above 25 ° C.
Do not freeze.
Keep out of reach of children.

package
Tube, 40 g, packed in laminated cardboard box with all the necessary particulars and information leaflet.
Propylene container, 400 g.