DIFLAZON 100 ml.

DIFLAZON WHAT IS AND WHAT IT IS USED FOR?
100 ml of infusion solution (1 vial) contains 200 rag fluconazole. (1 ml of infusion: solution contains 2 mg fluconazole.)
 
 
package
Cardboard box with a bottle of 100 ml solution for infusion.
 
What is Diflazon?
Fluconazole is a new active substance antimycotic (antifungal) from the group of thiazoles. It inhibits the growth of fungi. Used for prevention and treatment of diseases caused by various types of fungi. It is effective in topical fungal infections of the skin, mouth, and vagina, and yeast infections of the internal organs (systemic infection).
 
 
What is Diflazon?
Diflazon be used for treatment of:
• Acute and chronic systemic candidiasis of the cardiovascular system, respiratory system, urinary tract infections in neutropenic and non-neutropenic patients stable.
• infections of skin or mucosa caused by Candida (thrush mucosal): infections of the mouth, lungs, urinary tract, including patients infected with HIV and other immunocompromised patients;
• systemic infections with Cryptococcus: meningiapni infections (cryptococcal meningitis), lungs and skin.
• Diflazon may also be used for the prevention of candidiasis infections (prevention of candidiasis) prior to transplantation of hematopoietic cells in patients with malignant disease susceptible to such infections as a result of treatment with cytostatics or radiation therapy.
 
 
2. BEFORE YOU USE DIFLAZON
Tell your doctor if you have any chronic disease, metabolic disease, if you are hypersensitive (allergic) or if you take other medicines.
 
Who should not take Diflazon?
You should not take this medicine if you are allergic to fluconazole, other azole compounds and some of the excipients produkt.Fluconazole inhibits the activity of chernodrobvata enzyme P450, which can affect the metabolism of certain products a dosage (terfenadine, cisapride). Co-administration of these drugs is contraindicated.
 
Special precautions and warnings
In patients with impaired renal function requires attention. In these patients, the doctor will decide the dose.
In patients with hepatic impairment also requires attention. If there is an increased hepatic enzyme activity, the doctor will consider the potential benefit versus the risk of continued therapy.
There is insufficient experience for the application of Diflazon in children less than 6 months, so the doctor will have to decide such use at its discretion.
 
pregnancy
Consult to your doctor or pharmacist before taking any medicine produkt.Tay as complete security during pregnancy has not been confirmed, the doctor should prescribe Diflazon only when the expected benefit to the mother outweighs the risk to the fetus.
 
breastfeeding
Consult to your doctor or pharmacist before taking any medicine produkt.Fluconazole is excreted in breast milk, so you should not breast-feed during treatment with Diflazon.
 
Effects on ability to drive and use machines
It is not known the drug affects the ability to drive and use machines.
 
What other drugs interact with Diflazon?
Tell your doctor or pharmacist if you are taking or have taken any medicines, even those without a prescription.
If fluconazole is taken simultaneously with certain other medicines may occur drug interaction and the effect of fluconazole or other medicines to reduce or increase.
 
Tell your doctor or pharmacist if you are taking:
• medications for the treatment of hypersensitivity reactions
• drugs that affect the intestinal peristalsis
• medicines to prevent blood clotting (coumarin anticoagulants), medicines for the treatment of diabetes (sulfonylureas derivatives)
• medicines that increase urine output (hydrochorothiazide),
• medicines for the treatment of epileptic seizures (phenytoin),
• medicinal products for the treatment of tuberculosis (rifampicin),
• medicines that suppress the immune response (cyclosporine),
• medicinal products for the treatment of chronic bronchitis and asthma (theophylline),
• hypnotic and sedative drugs (midazolam),
• medicines to treat HIV (indinavir, zidovudine).
 
 
3. HOW TO USE DIFLAZON?
 
Dosage and method of administration
Failing oral recommended intravenous infusion therapy with a solution of fluconazole 200mg per hour. Patients should be switched to oral treatment as soon as possible. The daily dose does not need to be changed. During the first day of treatment usually prescribed a double dose compared with its prescribed. children
The normal adult maximum daily dose should not be exceeded in children. Fluconazole should be appointed on the basis of a single daily dose according to the weight of deteto.Pri normal renal function, life-threatening Candida infections in children treated with 6 mg to 12 mg fluconazole / kg daily. For the prevention of fungal infections and the treatment of superficial mycoses should be administered a dose of 3 mg to 6 mg / kg fluconazole .Maksimalnata daily dose is 12 mg / kg, and for children from 5 to 13 years of age 400 mg fluconazole.
During the first two weeks of life, infants should receive the same dose as older children, but prescribed 72 hours. For children from 2 to 4 weeks, the same dose should be administered 48 hours.
As in adults, the duration of treatment in children depends on the clinical condition and treatment response
Typically, treatment is continued for some time after the symptoms of the disease disappear
In children with renal insufficiency, your doctor will reduce the dose as recommended for vazrastni.Sled each hemodialysis (artificial kidney) is usually necessary to provide additional single dose of 50 mg to 200 mg fluconazole. In patients on CAPD (continuous ambulatory peritoneal dialysis) recommended dose of 150 mg fluconazole be used in 2-liter dialysis bag at intervals of two days. If gshate impression that the effect of the medicine was too loud your too weak, talk to your doctor or pharmacist.
 
If you take more than you should Diflazon
The most common symptoms of overdose are nausea, vomiting, diarrhea and in severe cases - garchove.V case of overdose the doctor will take appropriate measures.
 
If you forget to take Diflazon
The doctor will determine how often be applied infusion. If for some reason you do not get the infusion at the appointed time, tell your doctor as soon as possible.
 
Effect on treatment if you stop taking Diflazon
Discontinuation of treatment without consulting your doctor can be dangerous. With prolonged treatment you should consult with your doctor before stopping treatment.
 
4. POSSIBLE SIDE EFFECTS
Like all medicines, Diflazon can also have side effects. Possible side effects are most often by the gastrointestinal tract, nausea, flatulence, vomiting, abdominal pain and diarrhea. Also possible are headache, seizures, and hair loss (alopecia). Hypersensitivity reactions are very rare (skin rash, anaphylaxis and angioedema). They require immediate discontinuation of treatment.
In patients with severe fungal infections can cause changes in blood parameters such as leukopenia and thrombocytopenia (decrease in the number of leukocytes and platelets), increased activity of liver enzymes and severe hepatic impairment.
If you notice the occurrence of any side effects of medicine, tell your doctor or pharmacist.
 
 
5. HOW TO STORE DIFLAZON
Shelf godnostDa not be used after the expiry date stated on the packaging.
 
 
Storage Conditions
Do not store above 30 ° C.
Keep out of reach of children.
 
 
6. INSTRUCTIONS FOR MEDICAL STAFF
The amount of the intravenous infusion should not exceed 200 mg / hr.
 
 
Incompatibilities
It is not recommended to mix the solution for infusion of fluconazole with other medicinal products.