Fungolon caps. 150 mg. 4 capsules

 

Fungolon WHAT IS AND WHAT IT IS USED FOR?

Fungolon is medicine of the so-called. antifungals

 

Fungolon is used to treat:

 

Fungolon treatment can begin before the results of microbiological and other laboratory tests. If it is necessary, after obtaining these results, the treatment may be changed accordingly.

 

Fungolon is used to treat the following conditions:

 

 Genital candidiasis - Acute or recurrent vaginal candidiasis, candida balanitis.

 Mucosal candidiasis - oropharyngeal, esophageal, non-invasive bronchopulmonary infections, candiduria, mucocutaneous and chronic oral atrophic candidiasis.

Pedis mud, mud korporis, kruris mud, mud verzikolor and skin candida infections

 Systemic candidiasis including candidemia, disseminated candidiasis and other invasive candida infection.

 Cryptococcosis, incl. cryptococcal meningitis and infections of other sites. It is used in patients with AIDS, organ transplant or other slachai immunosuppression.

 The prevention of fungal infections in immunocompromised patients at risk of neutropenia following cytotoxic chemotherapy or radiation therapy.

 

 

BEFORE YOU TAKE Fungolon

 

Fungolon not take if:

 

 You have a hypersensitivity to fluconazole or to any of the excipients, or to other azoles

 Are treated with medicinal products that are known to cause changes in the electrocardiogram.

 

 

Taking Fungolon with food and drink

 

No special requirements

 

 

Pregnancy and lactation

 

Fungolon in standard doses and short-term administration should not be used during pregnancy, except in cases of extreme necessity. Fungolon at high doses and / or long-term should not be used during pregnancy except in cases of severe and potentially life-threatening fungal infections.

Fungolon passes into breast milk, reaching concentrations lower than those in plasma. Breastfeeding may continue after a single standard dose of 200 mg or less. Not recommended for continued breastfeeding after priloenie multiple doses or high doses of the product.

 

Driving and operating machinery

 

Fungolon no or negligible influence on the ability to drive and use machines.

However, when driving vehicles or operating machines, it should be noted that it is possible to appear dizziness and loss of consciousness.

 

Important information about the ingredients of Fungolon

 

This medicinal product contains lactose as an ingredient, which makes it unsuitable for patients with lactose intolerance.

 

 

HOW TO TAKE Fungolon

 

Fungolon taken orally.

The daily dose of the product is determined in the basis of the type and severity of the fungal infection. Most cases of vaginal candidiasis respond to single dose. Treatment of these types of infections requiring multiple dose should be continued until clinical parameters and laboratory tests indicate passage of active fungal infection. Inadequate treatment may lead to recurrence of active infection. Patients with AIDS and cryptococcal meningitis usually require maintenance therapy to prevent relapse.

 

Adults:

 

Candida vaginitis or balanitis - 150 mg orally once

 Mucosal candidiasis

Oropharyngeal candidiasis - 200 mg per day the first day and 100 mg daily coming days. Therapy should not exceed 14 days, except for immunocompromised patients in critical condition.

For atrophic oral candidiasis associated with dentures - usual dose of 50 mg once daily for 14 days, concurrently with the use of topical antiseptics.

In other candidal infections of mucosa except genital candidiasis and esophagitis, non-invasive bronchopulmonary infections, candiduria, mucocutaneous candidiasis, the usual dose is 200 mg on the first day and 100 mg daily coming days.

 

In other candidal infections of mucosa except genital

 For Tine pedis, korporis, kruris, verzikolor and skin candida infections the recommended dose is 50 mg once a day .. Treatment duration is usually 2 to 4 weeks, but Tine pedis may require treatment for up to 6 weeks. The length should not exceed six weeks.

 For candidemia, disseminated candidiasis and other invasive candida infections the usual dose is 400 mg on the first day followed by 200 mg daily. Depending upon the clinical response, the dose may be increased to 400 mg daily. The duration of treatment is determined by the clinical response.

 For cryptococcal meningitis and cryptococcosis infections in other locations the usual dose is 400 mg the first day followed by 200 mg-400 mg once daily. The duration of treatment depends on clinical and mycological response but is usually recommended after 10-12 weeks of treatment clearance of culture of CSF for cryptococcal meningitis.

 Prevention of recurrence of cryptococcal meningitis in patients with AIDS after the patient received a full course of primary therapy Fungolon can be used indefinitely at a dose of 100-200 mg

The prevention of fungal infections in immunocompromised patients at risk of neutropenia after cytotoxic chemotherapy or radiation therapy, the dose should be 50 to 400 mg once daily, depending on the patient's risk of developing a yeast infection. For patients at high risk of systemic infections, such as those who are expected to have a severe and prolonged neutropenia as in bone marrow transplantation, the recommended dose is 400 mg once daily. Taking Fungolon tryabvda start several days before the anticipated onset of neutropenia and continue for 7 days after the number of neutrafilite rises above 1000 cells per mm2.

 

Children

 

As with similar infections in adults, the duration of treatment is based on clinical and mycological response. Fungolon taken as a single dose each day.

 

Children over 4 years

 

The recommended dose for mucosal candidiasis is 3 mg / kg daily. Loading dose of 6 mg / kg was administered the first day for the rapid attainment of steady state.

For the treatment of systemic candidiasis and Cryptococcal infections, the recommended dose is 6-12 mg / kg daily, depending on disease severity.

For the prevention of fungal infections in immunocompromised patients at risk of neutropenia following cytotoxic therapy and radiation therapy, the dose should be 3-12 mg / kg daily, depending on the extent and duration of the induced neutropenia.

Maximum dose for children should not exceed 400 mg daily.

There are limited data on use in genital candidiasis in children under 16 years. Application of the product is not recommended unless absolutely necessary lecheniet and no alternative products to use.

 

Elderly

 

In the absence of evidence of renal impairment should follow the normal dose. In patients with renal impairment, the dose should be modified as indicated below.

 

POSSIBLE SIDE EFFECTS

 

There are reports of the following adverse reactions:

General:

Uncommon - fatigue, malaise, otpadnolost, fever

 

Nervous system disorders:

Common - headache

Uncommon - dizziness, convulsions, seizures, tremors, vertigo

 

Skin and subcutaneous tissue disorders:

Common - skin rash

Uncommon - itching, increased potlivost hair loss

Rare - severe skin damage

 

Gastrointestinal disorders:

Common - nausea, vomiting, korechni pain disorder

Uncommon - anorexia, constipation, indigestion, dry mouth, altered taste

Musculo-skeletal system:

Uncommon - muscle pain

Psychiatric disorders:

Uncommon - insomnia, somnolence

 

Hepatobiliary disorders

Common - elevation of liver parameters

Uncommon - cholestasis, liver cell damage, hepatitis, jaundice, increase in bilirubin

Rare - hepatic necrosis

 

Immune system disorders:

Rare - anaphylaxis

Very rare - angioedema, pruritus, urticaria

 

ADDITIONAL INFORMATION

 

What Fungolon

Active ingredient: fluconazole

The other ingredients are lactose monohydrate, pregelatinized starch, silica colloidal anhydrous, magnesium stearate