LOSTRAZIN 100 mg. 60 tablets

What is LOSTRAZIN and what is it used for?
The drug LOSTRAZIN refers to a group of medicines called phosphodiesterase type 3 inhibitors.
It works in several ways, including expanding blood vessels and reducing the ability to clot (cling) blood cells called platelets in the blood vessels.
LOSTRAZIN is prescribed for the treatment of "intermittent claudication" (periodic limp). Intermittent claudication occurs with spasm-like leg pain when walking due to insufficient blood supply to the limbs. Lorrassin can increase the distance you can walk without pain as it improves the circulation in the legs. Cilostazol is only recommended for patients whose symptoms have not improved well after lifestyle changes (such as stopping smoking and increasing exercise) and other appropriate treatments. It is important to continue with the changes you have made in your lifestyle while taking cilostazol.
2. What do you need to know before taking Lorustazine?
Do not take LOSTRAZIN
If you are allergic to cilostazol or any of the other ingredients of this medicine (listed in section 6);
If you have a condition called "heart failure" (resulting in easy tiredness, shortness of breath, swelling of the ankles, etc.);
If you have strenuous chest pain at rest or have had a "heart attack" or some surgery during the last six months;
If you currently suffer or have suffered from a temporary loss of consciousness due to heart disease or severe heart failure;
If you are known to have an illness that increases the risk of bleeding or bruising such as:
Active gastric ulcer (s);
Stroke (stroke) in the last six months;
Eye problems if you suffer from diabetes;
If your blood pressure is not well controlled.
If you are taking acetylsalicylic acid and clopidogrel, or any combination of two or more medicines that may increase the risk of bleeding (if you are not sure, ask your doctor or pharmacist);
If you have severe kidney disease or moderate or severe hepatic disease;
If you are pregnant.
Warnings and precautions
Talk to your doctor or pharmacist before taking Lorrassin.
You should make sure that your doctor knows:
If you suffer from severe heart disease or other heart problems;
If you have problems with your blood pressure.
During treatment with Lorusthin it must be ensured that:
If you need surgery, including tooth extraction, you will tell your doctor or dentist that you are taking LOSTRAZIN
If you notice easily bleeding or bruising, you should stop taking Lorustazine and tell your doctor.
Other medicines and LOSTRAZIN
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
In particular, you should tell your doctor if you are taking medicines that are commonly used to treat muscle or joint conditions accompanied by pain and / or inflammation, or if you are taking medicines to reduce blood clotting. These medicines are:
acetylsalicylic acid;
Clopidogrel;
Anti-caking agents (eg warfarin, dabigatran, rivaroxaban, apixaban or low molecular weight heparins).
If you are taking these medicines with Lorustazine, your doctor may have some regular blood tests.
Certain medicines may affect the effect of Lorrassin when taken at the same time. They may either increase the incidence of side effects of Lorusthine or reduce the effect of Lorusthine and make it less effective. Lorrassin may have a similar effect on other medicines.
Before you start taking LOSTRAZIN, tell your doctor if you are taking:
Erythromycin, clarithromycin or rifampicin (antibiotics);
Ketoconazole (for the treatment of fungal infections);
Omeprazole (for the treatment of increased acidity in the stomach);
Diltiazem (for the treatment of high blood pressure or chest pain);
Cisapride (to treat stomach upsets);
Lovastatin, simvastatin or atorvastatin (for the treatment of high blood cholesterol);
Halofantrine (for the treatment of malaria);
Pimozide (for the treatment of mental illness);
Morphine derivatives (for the treatment of migraine, eg ergotamine, dihydroergotam);
Carbamazepine or phenytoin (to treat seizures);
St. John's wort (herbal product).
If you are not sure whether this applies to your medicines, ask your doctor or pharmacist.
Before you start taking LOSTRAZIN, tell your doctor if you are taking medicines to lower your blood pressure, as Lorusthin may further lower your blood pressure. If your blood pressure falls too high, it may cause a rapid heartbeat. These medicines are:
Drainage agents (such as hydrochlorothiazide, furosemide);
Calcium channel blockers (eg verapamil, amlodipine);
ACE inhibitors (such as captopril, lisinopril);
Angiotensin II receptor antagonists (eg valsartan, candesartan);
Beta-blockers (such as labetalol, carvedilol).
You may be able to take both the above mentioned medicines and Lorrassin at the same time. Your doctor will be able to decide what is right for you.
Lorrassin with food, beverages and alcohol
Lorusthin tablets should be taken 30 minutes before breakfast and dinner. Always take the tablets with water.
Pregnancy, breastfeeding and fertility
LOSTRAZIN MUST NOT be taken during pregnancy.
LOSTRAZIN is not recommended for women who are breast-feeding.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.
Driving and using machines
Lorrassin may cause dizziness. If you feel dizzy after taking Lorrassin tablets, DO NOT drive or use any tools or machines and tell your doctor or pharmacist.
3. How to take LOSTRAZIN?
Always take this medicine exactly as your doctor has told you. If you are not sure, ask your doctor or pharmacist.
The recommended dose is one 100 mg tablet twice a day (morning and evening). This dose should not be changed in elderly patients. However, your doctor may prescribe a lower dose if you are taking other medicines that may affect Lorrassin.
Lorusthin tablets should be taken 30 minutes before breakfast and dinner. Always take the tablets with water.
In some cases, you may feel the benefit of taking Lorustazine within 4-12 weeks of starting treatment. Your doctor will evaluate the development of your illness after 3 months of treatment and may recommend discontinuation of cilostazol if the effect of treatment is insufficient.
Use in children and adolescents
Lorrassin is not suitable for use in children.
If you take more Lorustazine than you should
If you have taken more Lorrosine than you should, you may experience signs and symptoms such as headache, diarrhea, low blood pressure, and heart rhythm disorders.
If you take more tablets than you prescribed, contact your doctor or local hospital immediately. Do not forget to take the pack with you to understand what medication you have taken.
If you forget to take LOSTRAZIN
If you miss a dose, do not worry - wait until the next intake to take the next tablet and proceed as normal. DO NOT take a double dose to make up for the forgotten tablet.
If you stop taking LOSTRAZIN
If you stop taking LOSTRAZIN, the pain in your legs may recover or get worse. Therefore, you should stop taking LOSTRAZIN only if you notice any side effects that require urgent medical attention (see section 4) or if your doctor tells you to do so.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everyone gets them.
If you experience any of the following side effects, stop taking Lorusthine and contact your doctor immediately or go to the nearest hospital as urgent medical help may be necessary:
Stroke;
heart attack;
Heart problems that can cause shortness of breath or swelling of the ankles;
Irregular heartbeat (emerging or worsened);
Visible bleeding;
Easy bruising;
Severe blistering of the skin, mouth, eyes and genitals;
Yellowing of the skin or whites of the eyes caused by liver or blood problems (jaundice).
You should also immediately inform your doctor if you have a fever or sore throat. Some blood tests may need to be done before resuming treatment again.
The following side effects have been reported with Lorustazine, for which you should tell your doctor as soon as possible:
Very common side effects (may affect more than 1 in 10 patients):
headache;
Unusual stools;
Diarrhea.
Common side effects (may affect up to 1 in 10 patients):
Increased heart rate;
Severe palpitation (palpitations);
Chest pain;
Dizziness;
sore throat;
Rhinitis (rhinitis);
Abdominal pain;
Stomach discomfort (indigestion);
Nausea or vomiting;
Lack of appetite (anorexia);
Excessive burping or gas (flatulence);
Swelling of the ankles, feet or face;
Rash or change in the appearance of the skin;
Itchy skin;
Spotting bleeding on the skin;
general weakness.
Uncommon side effects (may affect up to 1 in 100 patients):
heart attack;
Irregular heartbeat (emerging or worsened);
Heart problems that can cause shortness of breath or swelling of the ankles;
Pneumonia;
Coughing;
Chilling;
Unexpected bleeding
Bleeding tendencies (eg bleeding in the stomach, eyes or muscles, nose and blood in the phlegm or urine);
Reducing the number of red blood cells in the blood;
Dizziness in straightening;
Seizure;
Anxiety;
Difficulty falling asleep;
Unusual dreams;
alergic reaction;
Pains;
Diabetes and increased blood sugar;
Stomach pain (gastritis);
Malaise.
There may be an increased risk of bleeding into the eye in people suffering from diabetes.
Rare side effects (may affect up to 1 in 1,000 patients):
Tendency to longer bleeding than usual;
Increased platelet counts in the blood;
Kidney problems.
The following side effects with an unknown frequency for which no frequency can be estimated from the available data have been reported with Lorrassin:
Changes in blood pressure values;
A decrease in the number of red and white blood cells and platelets in the blood;
Difficulty in breathing;
Difficult movements;
Fever;
Hot waves;
Eczema and other skin rashes;
Decreased skin sensitivity;
Secretion of the eye or conjunctivitis;
Ringing in the ears (tinnitus);
Liver problems, including hepatitis;
Changes in urine.
How to store LOSTRAZIN?
Keep out of the reach and sight of children.
Do not use this medicine after the expiry date which is stated on the carton and on the blister after EXP. Expiration date corresponds to the last day of that month.
Do not use this medicine if the integrity of the pack is visibly disturbed and / or the appearance of the tablets is different from that described at the end of this leaflet.
This medicinal product does not require any special storage conditions.
Do not dispose of medicines in the sewers or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.
6. Package Contents and Additional Information
What LOSTRAZIN contains?
The active substance is cilostazol. One tablet contains 100 mg of cilostazol.
The other ingredients are: corn starch, microcrystalline cellulose, carmellose calcium, hypromellose and magnesium stearate.
What does Lorrassin look like and contents of the pack
Each Lorastine 100 mg tablet is white to off-white, round, flat, debossed with "100" on one side.
The medicine is available in packs of 28, 30, 56, 60 tablets, packed in PVC / PVDC / aluminum foil blisters.
Not all packs may be put up for sale.

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