NOLIPREL BI-FORTE 10 mg. / 2.5 mg. 30 tablets

NOLIPREL BI-FORTE is a combination of two active ingredients perindopril and indapamide. It is antihipertinzivno agent and is used to treat high blood pressure. It is prescribed to patients who are already taking 10 mg of perindopril and indapamide 2.5 mg in separate tablets, these patients may instead receive one tablet Noliprel Bi-Forte which contains both ingredients.
What is Bi-Noliprel Forte?
Perindopril belongs to a class of drugs called ACE inhibitors. They work by widening the blood vessels, which relieves the heart to pump blood through them. Indapamide is a diuretic. Diuretics increase the amount of urine produced by the kidney. Indapamide, however, was different from other diuretics, as it leads to a very slight increase in the amount of urine formed. Each of the active ingredients lowers blood pressure, and taken together they result in better control of blood pressure.

BEFORE YOU TAKE NOLIPREL BI-FORTE
Do not take Noliprel Bi-forte:
- If you are allergic to perindopril or any other ACE inhibitor, or to indapamide or other sulfonamides or to any of the ingredients of Noliprel Bi-forte.
- If you have experienced symptoms such as wheezing, swelling of the face or tongue, intense itching or severe skin rashes with previous ACE inhibitor treatment or if your blood relatives have had in other circumstances such symptoms;
- If you have severe liver disease or suffer from a condition called hepatic encephalopathy;
- If you have kidney disease or are on dialysis;
- If you have high or low blood potassium;
- If you suspect that you are untreated cardiac decompensation / dezhka water retention, difficulty breathing /;
- If you are pregnant after the third month;
- If you are breastfeeding

Taking other medicines:
It should avoid the use of Noliprel Bi-forte with:
- Lithium
- Potassium-sparing diuretics, potassium salts.
Treatment with Soliprel Bi-forte may be affected by other medicines. Make sure to tell your doctor if you are taking any of the following medicines as they may need special attention:
- Other medicines used to treat high blood pressure;
- Procainamide;
- Allopurinol;
- Terfenadine and astemizole;
- Corticosteroids used to treat various conditions, including. severe asthma and rheumatoid arthritis;
- Immunosuppressants used for the treatment of autoimmune disorders or following transplant surgery to prevent rejection of the transplanted organ;
- Drugs to treat cancer;
- Injection erythromycin;
- Halofantrine;
- Pentamidine;
- Vincamine;
- Bepridil;
- Sultopride;
- Medicines used for heart rhythm problems;
- Digoxin or other sarzechni glycosides;
- Baclofen;
- Drugs to treat diabetes such as insulin or metformin;
- Calcium supplements including calcium supplements;
- Laxatives, stimulating peristalsis;
- NSAIDs;
- Amphotericin B injections;
- Drugs to treat psychiatric disorders such as depression, anxiety, schizophrenia;
- Tetracosactide

Pregnancy and lactation:
Ask your doctor before taking any medicine during pregnancy.
Usually your doctor will advise you to stop taking Noliprel Bi-forte before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead.
Noliprel Bi-forte is contraindicated in mothers who are breastfeeding, and your doctor may choose another treatment for you if you wish to breastfeed, especially if your baby is newborn, or born prematurely.

HOW TO TAKE NOLIPREL BI-FORTE?
Always take your medicine exactly as your doctor has said. If you're not sure, ask. The usual dose is one tablet daily. It is preferable to take the tablet in the morning and before meals. Take the tablet with a glass of water.

POSSIBLE SIDE EFFECTS
If you experience any of these effects, stop taking the medicinal product immediately and tell your doctor immediately.
- Swelling of the face, lips, mouth, tongue or throat, difficulty in breathing.
- Severe dizziness or fainting.
- Unusually fast or irregular heartbeat.
Common side effects - headache, dizziness, vertigo, tingling, visual disturbances, tinnitus, dizziness due to low blood pressure, cough, shortness of breath, gastrointestinal disorders, allergic reactions, muscle cramps, feeling tired .
Uncommon - mood swings, sleep disturbances, bronchospasm, angioedema ,, urticaria, purpura, kidney problems, impotence, sweating.
Very rare - confusion, cardiovascular disorders, heart attack, rhinitis, severe skin manifestations such as erythema multiforme. If you suffer from systemic lupus erythematosus, may deteriorate. There have been reports of outbreaks of photosensitivity after exposure to sunlight or artificial UV rays.
Possible blood disorders, kidney, liver or pancreas and changes in laboratory parameters. You may need your doctor to blood tests to monitor your condition.
In cases of liver failure, there is a risk of occurrence of hepatic encephalopathy. If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor.

MORE INFORMATION:
What Noliprel Bi-forte:
The active substances are perindopril arginine and indapamide. One tablet contains 10 mg of perindopril arginine and 2.5 mg indapamide.
The other ingredients in the tablet core are lactose monohydrate, magnesium stearate, maltodextrin, silica, hydrophobic colloidal, sodium starch glycolate, and in the film coating of the tablet: glycerol, hypromellose, macrogol, magnesium stearate, titanium dioxide.