VASOCARDIN 100 mg. 30 tablets

What is VASOCARDIN and what is it used?

Metoprolol, the active substance of Vazokardin 50mg and 100 mg belongs to a group of medicines called beta-blockers. Goy reduces heart rate and blood pressure, especially under load. Metoprolol lowers blood pressure, when used alone or in combination with other medicines. Improves exercise capacity load and reduces the frequency of angina attacks (chest pain due to insufficient blood supply to the heart).

Medicinal product used in the treatment of high blood pressure, prevention of angina attacks, treatment of some forms of arrhythmias, increased heart rate at elevated thyroid function, prevention of migraine attacks, and in patients after myocardial infarction.

Medicinal product intended for the treatment of adults.
2. What you need to know before taking VASOCARDIN?

  Do not take VASOCARDIN 50 mg and 100 mg, if:

• You have a known hypersensitivity to the active substance metoprolol, other beta-blockers or any of the ingredients of this medicine (listed in section 6);

• You suffer from conduction or cardiac arrhythmias;

• you know that your blood with high acidity (a condition termed "metabolic acidosis");

• You have severe or uncontrolled heart failure;

• Are you in shock because of heart problems;

• You suffer from untreated phaeochromocytoma (high blood pressure caused by a tumor of the adrenal gland);

• You have a slow heartbeat;

• You have low blood pressure;

• Have or have had breathing problems or asthma, including COPD (chronic obstructive pulmonary disease that occurs with coughing, wheezing or shortness of breath).

If during treatment with this medicine show any of the above, tell your doctor about it ..

Warnings and Precautions

Talk to your doctor or pharmacist before taking VASOCARDIN if:

- You have or have had an allergic reaction, suffer from diabetes, bronchial asthma or poor circulation in the lower extremities;

- Do you have myasthenia gravis, psoriasis, or depression;

- You suffer from untreated phaeochromocytoma (high blood pressure caused by a tumor of the adrenal gland);

Children and adolescents

This medicine should not be prescribed to children due to insufficient clinical experience. Other medicines and VASOCARDIN

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines ..

Do not take Vazokardin 50 and 100 mg, if you already take:

- Monoamine oxidase inhibitors (MAO-inhibitors) used to treat depression;

- Verapamil. The product does not need to use the same time verapamil (a medicine to treat
high blood pressure and some conduction disturbances of the heart);

Before you start taking Vazokardin 50 mg or 100 mg tablets, tell your doctor if you are taking or have recently taken any of the following medications:

- Cimetidine: Concomitant use of medicines to treat stomach ulcers (cimetidine) and drugs that lower blood pressure can lead to increased effect of Vazokardin;

- Concomitant use of alcohol increases the levels of alcohol in the blood and lead to an extension of the effect;

- Diabetes medicines taken orally and insulin (to reduce blood sugar). Vazokardin enhances the effect of insulin and other drugs to reduce blood sugar levels (antidiabetics). In patients with diabetes, the symptoms of low blood sugar can be masked (increased incidence of heart rhythm). Other beta-blockers (eg. In eye drops); ganglioplegichni drugs; certain antiarrhythmics (such as amiodarone); cardiac glycosides (for the treatment of heart disease); rifampicin (antibiotic); hidrapazin, clonidine, prazosin (for treatment of high blood pressure);

- Naroksetin, fluoxetine, sertraline (selective reuptake inhibitors of serotonin);

- Indomethacin (NSAIDs NSAIDs);

- Antidepressants such as bupropion or tricyclic antidepressants;

- Local anesthetics;

- Barbiturates (for epilepsy);

- Phenothiazine (for treatment of some mental disorders);

- Xanthine (for asthma);

- Adrenaline (epinephrine) and other sympathomimetic agents;
VASOCARDIN 50 mg and 100 mg with food, drinks and alcohol

The tablets should be taken always at the same time of the day, preferably with food and some fluid.

Concomitant use of alcohol should be avoided, as alcohol may enhance the blood pressure lowering effect of Vazokardin 5 () mg. 100 mg tablets ..

Pregnancy and lactation

If you are pregnant or breast-feeding, think you may be pregnant or planning to become pregnant, ask your doctor or pharmacist before taking this medicine.

Pregnant women and lactating women can use this product only if it is absolutely necessary.

Driving and using machines

Medicinal product may adversely affect the activities requiring alertness, motor coordination and quick decision-making, especially at the beginning of treatment, when they occur fatigue and dizziness.

Vazokardin 50 mg and 100 mg contains lactose

If your doctor has warned that you have an intolerance to some sugars, contact him before you start using this medicine. Vazokardin tablets contain lactose, why one hundred patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

3. How to take VASOCARDIN 50 mg and 100 mg?

Always take this medicine exactly as prescribed by your doctor or pharmacist. If you are not sure, ask your light /) or pharmacist.

The exact dosage and duration of treatment should always be determined by the doctor. The recommended dose for the treatment of high blood pressure is generally 2 to 4 tablets Vazokardin 50 mg or I to 2 tablets Vazokardin 100 mg daily, divided into two separate doses.

In the prevention of angina attacks usually must be taken Vazokardin 1 tablet 50 mg tablet I Vazokardin 100 mg twice daily.

In the treatment of certain heart rhythm disturbances (arrhythmias) are usually taken daily 1 tablet Vazokardin 50 mg tablet I Vazokardin 100 mg.

For maintenance treatment, after recent myocardial infarction usually has 1 tablet Vazokardin 50 mg tablet or I Vazokardin 100 mg twice daily.

In the prophylaxis (prevention of relapses) of migraine generally be administered 2 tablets Vazokardin 50 mg tablet or I Vazokardin 100 mg twice daily.

The increased activity of the thyroid gland usually requires treatment with I Vazokardin tablet 50 mg twice daily.

If you think the effect of Vazokardin 50 mg and 100 mg is too strong or too weak, tell your doctor or pharmacist about it.

Always take this medicine exactly as described in this leaflet or as you have been told by your doctor or pharmacist. If you are not sure, ask your doctor or pharmacist.

Use in children and adolescents

The product is not intended for the treatment of children and adolescents.

If you take more dose VASOCARDIN

Do not take more tablets than your doctor prescribes.

Overdose or accidental ingestion by children, seek medical advice.

If you forget to take VASOCARDIN.

If you forget to take a dose, take it as soon as you found it; take the next dose according to the usual schedule. If the next dose time is short, do not use the missed dose and take the next normal dose (not higher!). Do not take a double dose to make up for a forgotten tablet.

If you stop taking VASOCARDIN

Do not stop treatment without consulting your doctor.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Very common (may affect more than I to 10 users): fatigue.

Common (may affect more than 1 in 10 100 users):

- Drowsiness or trouble sleeping;

- Malaise, abdominal pain.

Uncommon (may affect I to 10 users in 1,000): -koshmari;

-zamayanost headache; slow heartbeat;

-nedostig of breath with or without exercise.

Rare (may affect 1 to 1000 10 000 users);

-maskirane symptoms of low blood sugar;

-depresiya;

- Impaired concentration: -chuvstvo of stinging, burning, tingling; -abnormen heart attack (palpitations)
-heart arrhythmias -heart failure

- Fainting upon standing due to low blood pressure;

- Raynaud's syndrome (due to poor blood supply to the fingers may be stiff, pale and bluish, pain); -zatrudneno breathing;

- Diarrhea, indigestion or constipation;

- Rash, allergic skin reactions - hives, eczema, psoriasiform rash;

- Muscle cramps; -seksualni violations;

- Water retention, leading to edema;

- Increased triglycerides and cholesterol in the blood;

Very rare (may affect up to 1 in 10,000 users):

- A reduction in platelet counts;

- Anxiety, nervousness, memory impairment

- Confusion, hallucinations;

- Taste disturbances;

- Visual disturbances, dry or irritated eyes; -zvanene in the ears;

- Cardiac conduction abnormalities

- Development of a limp or deterioration;

- Gangrene in patients with severe peripheral circulation;

- Inflammation of the nose;

- Dry mouth;

- Hepatitis (symptoms include fever, fatigue and yellowing of the skin or whites of the eyes caused by liver problems or blood);

- Hair loss; Intensification sweating; -fotochuvstvitelnost; -vloshavane of psoriasis;

- Pain in the joints;

- Increased weight;

- Abnormal liver function tests.

If you get any side effects, tell your doctor or pharmacist. This includes any possible effects not listed in this leaflet.

5. How to store VASOCARDIN 50 mg and 100 mg?

Keep out of the reach and sight of children.

Keep sex between 25 "C. Protect from moisture and light.

DO NOT use this medicine after the expiry date stated on the carton after the abbreviation used to mark the expiry date. The expiry date refers to the last day of that month.

Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Contents of the pack and other information
What VASOCARDIN 5 (1 mg and 100 mg?

The drug substance is metoprolol tartrate 50 mg or 100 mg in each tablet.
Excipients: lactose, corn starch, microcrystalline cellulose, methylated silica, silica colloidal anhydrous, povidone 25 sodium starch glycolate, calcium stearate.