Indapamide 1.5 mg. 30 tablets

What is indapamide SR alkaloid-INT and what is it used?
This medicine is intended to reduce high blood pressure (hypertension). These are prolonged-release tablets containing indapamide as active substance.
Indapamide is a diuretic. Most diuretics increase the amount of urine excreted through the kidneys. However, indapamide is different from other diuretics, as it only causes a slight increase in urine output.
2. What you need to know before taking indapamide SR alkaloid-INT?
Do not take indapamide SR alkaloid-INT:
if you are allergic to indapamide, other sulfonamides or to any of the other ingredients of this medicine (listed in section 6).
if you have severe kidney disease.
if you have severe liver disease or suffer from a condition called hepatic entsefapopatiya (liver problems which affect the brain and central nervous system).
if you have low levels of potassium in the blood
Warnings and Precautions
Talk to your doctor or pharmacist before taking indapamide SR alkaloids INT
- If you have liver problems,
- If you have diabetes,
- If you suffer from gout,
- If you have heart rhythm problems or kidney problems
- If you need to do research to see how it works your parathyroid gland.
You should tell your doctor if you have had reactions photo sensitivity (if your skin was too sensitive to light).
You may need Your doctor may do blood tests to check for low sodium or potassium or high calcium levels.
If you are elderly, please tell your doctor if you have had any kidney problems.
If you think any of these situations may apply to you, or have any questions or doubts about taking your medicine, you should consult your doctor or pharmacist.
Athletes should be aware that this medicine contains an active ingredient that can lead to a positive doping test.
Other medicines and indapamide SR alkaloid-INT
Tell your doctor or pharmacist if you are taking, you have recently taken or might take any other medicines.
You should not take indapamide SR alkaloid-INT with lithium (used to treat depression) due to the risk of increased levels of lithium in blood.
Be sure to tell your doctor if you are taking any of these medicines as may be required special care:
drugs used for heart rhythm problems (eg. quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, ibutilide, dofetilide, digitalis), drugs used to treat psychiatric disorders such as depression, anxiety, schizophrenia (eg. tricyclic antidepressants, antipsychotic drugs , neuroleptics),
bepridil (used to treat angina pectoris, a disease that causes pain in the chest),
cisapride (used to treat reduced movement of the esophagus and stomach), diphemanil (used to treat stomach problems such as ulcers, increased acidity, overactive digestive system),
sparfloxacin, moxifloxacin, intravenous erythromycin (antibiotic used to treat infections),
halofantrine (antiparasitic drug used to treat certain types of malaria),
pentamidine (used to treat certain types of pneumonia), mizolastine (used to treat allergic reactions such as hay fever), intravenous vincamine (used in the treatment of circulatory problems in the brain),
NSAIDs for pain relief (eg ibuprofen) or high doses of aspirin, angiotensin-converting enzyme (ACE) inhibitors (used to treat high blood pressure and cardiac insufficiency)
intravenous amphotericin B (used for the treatment of severe fungal disease)
oral corticosteroids used to treat various conditions including severe asthma and rheumatoid arthritis, stimulant laxatives,
baclofen (to treat muscle stiffness in diseases such as multiple sclerosis)
potassium-sparing diuretics (amiloride, spironolactone, triamterene), metformin (for diabetes),
iodinated contrast media (used for tests involving X-rays)
calcium tablets or other calcium supplements,
cyclosporine, tacrolimus, or other medications to suppress the immune system following organ transplantation, for the treatment of autoimmune diseases or severe rheumatic or dermatological diseases, tetracosactide (for the treatment of Crohn's disease).

Children and adolescents
Indapamide is not recommended for use in children and adolescents due to lack of data on safety and efficacy.
Pregnancy, lactation and fertility
If you are pregnant or breast-feeding, you think you may be pregnant or planning to become pregnant, ask your doctor or pharmacist before taking this medicine.
pregnancy
Not recommended this drug is administered during pregnancy. Tell your doctor if you are pregnant or planning to become pregnant. Your doctor will transfer to the alternative treatment as soon as possible.
breastfeeding
The active ingredient is excreted in human milk. Breastfeeding is not advisable if you are taking this medicine.
Driving and using machines
This medicine may cause side effects such as dizziness or tiredness due to lowering blood pressure (see. Section 4). These side effects are more likely to occur at the beginning of treatment and after dose increases. If you feel dizzy or tired, do not drive or perform other activities that require alertness. Under good control, these side effects are unlikely to occur.
Indapamide SR alkaloid-INT contains lactose.
If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this product.
3. How to take indapamide SR alkaloid-INT?
Always take this medicine exactly as you have been told by your doctor or pharmacist. If you're not sure, ask your doctor or pharmacist.
The recommended dose is one tablet each day, preferably in the morning. The tablets can be taken with or without food. Swallow the tablets whole with water. Do not crush or chew them.
Treatment of high blood pressure is usually for life.
If you take more dose indapamide SR alkaloid-INT
If you take too many tablets, tell your doctor.
Very high dose indapamide SR-INT alkaloids can cause nausea, vomiting, low blood pressure, cramps, dizziness, drowsiness, confusion and changes in the amount of urine excreted through the kidneys.
If you forget to take indapamide SR alkaloid-INT
If you forget to take a dose of your medicine, take the next dose at the regular time. Do not take a double dose to make up the missed dose.
If you stop taking indapamide SR alkaloid-INT
As the treatment for high blood pressure is usually life-long, you should discuss with your doctor before you stop taking this medicine.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.

If any of these side effects, contact your doctor immediately:
Very rare (may affect up to 1 in 10,000 people):
Angioedema (severe allergic reaction), which is characterized by swelling of the skin around the eyes, lips, arms or legs. It may cause swelling of the throat, tongue or airways, causing shortness of breath, or difficulty in swallowing.
Other possible side effects of indapamide SR alkaloid-INT:
Common (may affect up to 1 in 10 people):
Allergic reaction (especially in people who are prone to allergic or asthmatic reactions) leading to skin rashes and spots with pagtuli.
Low potassium levels in the blood which can result in muscle weakness.
Uncommon (may affect up to 1 in 100 people):
vomiting;
Allergic reactions (especially in people who are prone to allergic or asthmatic reactions), resulting in red spots on the skin (purpura).
Rare (may affect up to 1 in 1000 people):
Fatigue, dizziness, headache, tingling (paraesthesia);
Nausea, constipation, dry mouth;
Increased risk of dehydration in the elderly and patients suffering from heart failure.
Very rare (may affect up to 1 in 10,000 people):
Increased levels of calcium in the blood;
Irregular heart rhythm (causing palpitations, feeling of the heartbeat), low blood pressure;
Kidney disease (causing symptoms of fatigue, increased need to urinate, itchy skin, nausea, swollen extremities);
Liver problems (detected by blood tests);
Pancreatitis (inflammation of the pancreas, which causes pain in the upper abdomen), abnormal liver function (with symptoms such as fatigue, loss of appetite, nausea or vomiting, swollen extremities, yellow skin). In cases of liver failure it is possible to obtain hepatic encephalopathy (liver problems which affect the brain and central nervous system);
Changes in blood cells, such as thrombocytopenia (decrease of platelet count, which leads to easy bruising and bleeding of the nose), leukopenia (decreased white blood cells, which may cause unexplained fever, sore throat or other flu-like symptoms - if this happens, contact your doctor) and anemia (reduction in red blood cells);
Allergic skin reactions, especially in people who are prone to allergic or asthmatic reactions (angioedema, and / or urticaria, severe skin manifestations).
Not known (frequency can not be estimated from available data)
Changes may occur in your blood and you may need Your doctor may do blood tests to check your condition. May occur following changes in blood test results:
low sodium level in the blood which may lead to dehydration and low blood pressure,
increase in uric acid, a substance which may cause or aggravate
gout (painful (s) become (s), especially in the legs)
an increase in blood glucose levels in diabetic patients,
low levels of chloride in blood, which can lead to a metabolic alkalosis (low acidity of the blood)
elevated levels of liver enzymes;
If suffering from systemic lupus erythematosus (a disorder of the immune system, resulting in inflammation and damage to joints, ligaments and organs with symptoms including skin rash, fatigue, loss of appetite, weight gain and joint pain), the use of this drug may aggravate the disease;
Also reported cases of photosensitivity reactions (change in skin appearance) after exposure to the sun or artificial UVA;
If you have existing liver problems, the adoption of indapamide could lead to a condition called hepatic encephalopathy (damage to the brain and nerves, which can occur as a complication of liver disease); Pathological ECG heart tracing;
Life-threatening irregular rhythm {Torsade de Pointes);
hepatitis;
Fainting.
Adverse event reporting
If you get any side effects, talk to your pharmacist or light. This includes any possible effects not listed in this leaflet.
By reporting side effects, you can do your bit for getting more information on the safety of this medicine.
5. How to store indapamide SR alkaloid-INT?
Keep out of reach of children.
Do not use this medicine after the expiry date stated on the carton and blister after "EXP". The expiry date refers to the last day of that month.
This medicine does not require any special storage conditions. Store in the original container to protect from light.
Do not dispose of medications in wastewater or household waste.
Ask your pharmacist how to dispose of medicines no longer use. These measures will help to protect the environment.

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